69557-75-1Relevant academic research and scientific papers
Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists
Clark, Robin D.,Jahangir, Alam,Severance, Daniel,Salazar, Rick,Chang, Thomas,Chang, David,Jett, Mary Frances,Smith, Steven,Bley, Keith
, p. 1053 - 1056 (2007/10/03)
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl] amine] had analgesic activity in the rat.
An efficient route towards aromatic ketones without solvent and support under electromagnetic microwave activation
Brǎtulescu, George
, p. 175 - 177 (2007/10/03)
Five aromatic ketones were synthetized by Friedel-Crafts reaction from aromatic compounds and acid chlorides using electromagnetic micro-waves, without solvent and absorbent inorganic support.
