69688-12-6

Upstream product

• 98-92-0 nicotinamide 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 75-77-4 chloro-trimethyl-silane 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 

Downstream Products

• 23111-00-4 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside) 
• 1094-61-7 nicotinamide mononucleotide 
• 19132-12-8 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofur-2-yl]-1,4-dihydropyridine-3-carboxamide 
• 445489-49-6 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate 

Relevant academic research and scientific papers

Preparation method of beta-nicotinamide mononucleotide

The invention discloses a preparation method of beta-nicotinamide mononucleotide. According to the method disclosed by the invention, the beta-nicotinamide mononucleotide is prepared by taking a compound shown as a formula II as a raw material and sequentially carrying out glycosylation condensation, deprotection, phosphorylation and acylation protection group removal reaction. Compared with methods in the prior art, the method provided by the invention has the advantages of high yield, simple operation, easy purification of intermediates, good phosphorylation selectivity and the like.

Synthesis method of beta-nicotinamide mononucleotide

The invention discloses a synthesis method of beta-nicotinamide mononucleotide, and relates to the technical field of drug synthesis. The synthesis method mainly comprises the following steps of S1, mixing and reacting nicotinamide, hexamethyldisilazane and a catalyst I in a reaction kettle to obtain silanization-protected nicotinamide; S2, adding tetraacetyl ribose, a solvent, a catalyst II and methanol for reaction so as to generate nicotinamide triacetyl riboside; S3, adding methanol and n-propylamine to generate nicotinamide riboside; S4, adding trimethyl phosphate and phosphorus oxychloride to generate beta-nicotinamide mononucleotide; and S5, separating and purifying the beta-nicotinamide mononucleoside acid. According to the invention, a plurality of continuous steps are controlledto be carried out in one reaction container, and the steps of separating and purifying an intermediate are avoided, so that the method has the advantages of high yield and high production efficiency.

NICOTINAMIDE RIBOSIDE AND NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES FOR USE IN THE TREATMENTS OF MITOCHONDRIAL-RELATED DISEASES

Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating mitochondrial-related diseases or disorders.

Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs

A stereoselective synthesis of β-anomers of nicotinamide riboside (NAR), its deamidated analog (NaR), and of a nicotinamide C-methylated riboside derivative (NA3′-C-MeR) was developed. The β-anomers of N-ribofuranosylnicotine-3-carboxamide (β-NAR) and its nicotinic acid analog (β-NaR) were obtained by stereoselective synthesis via glycosylation of the presilylated bases under Vorbruggen's protocol. A NAR analog, methylated in position 3 of the ribosylic moiety, is also reported.