N,N-Bis(trimethylsilyl)-3-pyridinecarboxamide

Base Information

• Chemical Name: N,N-Bis(trimethylsilyl)-3-pyridinecarboxamide
• CAS No.: 69688-12-6
• Molecular Formula: C12H22N2OSi2
• Molecular Weight: 266.49
• Mol file: 69688-12-6.mol

Synonyms:

Chemical Property of N,N-Bis(trimethylsilyl)-3-pyridinecarboxamide

Chemical Property:

• PSA: 33.20000
• LogP: 3.19360

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Bis(trimethylsilyl)-3-pyridinecarboxamide

There total 3 articles about N,N-Bis(trimethylsilyl)-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloro-trimethyl-silane (75-77-4) + nicotinamide (98-92-0,1255150-40-3) → N,N-bis(trimethylsilyl)nicotinamide (69688-12-6)

Guidance literature:

With 1,1,1,3,3,3-hexamethyl-disilazane; at 150 ℃; for 12h;

Reference yield:

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + nicotinamide (98-92-0,1255150-40-3) → N,N-bis(trimethylsilyl)nicotinamide (69688-12-6)

Guidance literature:

With ammonium sulfate; at 125 ℃; for 8h; Temperature;

Reference yield:

nicotinamide (98-92-0,1255150-40-3) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → N,N-bis(trimethylsilyl)nicotinamide (69688-12-6)

Guidance literature:

With ammonium sulfate; In toluene; for 19h; Inert atmosphere; Reflux;

upstream raw materials:

chloro-trimethyl-silane

nicotinamide

1,1,1,2,2,2-hexamethyldisilane

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)

nicotinamide mononucleotide

1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofur-2-yl]-1,4-dihydropyridine-3-carboxamide

Refernces

• 1、 -. "Synthesis method of beta-nicotinamide mononucleotide". Paragraph 0027; 0029; 0031. . Retrieved 2020/09/20.
• 2、 Franchetti, Palmarisa,Pasqualini, Michela,Petrelli, Riccardo,Ricciutelli, Massimo,Vita, Patrizia,Cappellacci, Loredana. "Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs". . p. 4655 - 4658. Retrieved 2007/10/03.