6969-06-8

Upstream product

• 20432-02-4 1-(4-nitro-phenyl)-3-phenyl-propenone 
• 100-63-0 phenylhydrazine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 100-52-7 benzaldehyde 
• 100-42-5 styrene 
• 555-16-8 4-nitrobenzaldehdye 
• 59-88-1 phenylhydrazine hydrochloride 
• 1222-98-6 4-nitrochalcone 
• 98-86-2 acetophenone 
• 2960-55-6 (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 58794-54-0 3-(4-aminophenyl)-1,5-diphenyl-2-pyrazoline 
• 113918-31-3 4-{4-[3-(4-Nitro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-phenyl}-2,6-diphenyl-pyridine 
• 65558-42-1 1,3-Di(4-nitrophenyl)-5-phenyl-2-pyrazoline 
• 92708-89-9 1-(4-Sulfophenyl)-3-(4-nitrophenyl)-5-phenyl-2-pyrazoline 
• 62736-74-7 1-(p-Formylphenyl)-3-(p-nitrophenyl)-5-phenyl-2-pyrazoline 
• 105257-90-7 (4-Nitro-phenyl)-{4-[3-(4-nitro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-phenyl}-diazene 
• 92708-93-5 1-(4-Acetylphenyl)-3-(4-nitrophenyl)-5-phenyl-2-pyrazoline 

Relevant academic research and scientific papers

Spectroscopic studies of aryl substituted 1-phenyl-2-pyrazolines: Steric and electronic substitution effects

A series of aryl substituted 1-phenyl-2-pyrazolines containing electron-donating and electron-withdrawing substituents on different positions of the C3– or C5-aryl groups were synthesized and their steric and electronic effects on ch

TfOH mediated intermolecular electrocyclization for the synthesis of pyrazolines and its application in alkaloid synthesis

TfOH mediated easy access to interesting pyrazolines starting from an aldehyde, phenylhydrazine and styrene has been developed. The scope of this synthetic methodology has been explored by synthesizing various 1,3,5-trisubstituted pyrazolines in very good yields with very high regioselectivity. The origin of regioselectivity has been explained by comparing the stability of possible intermediate carbocations. The synthetic utility of a green solvent has been explored by synthesizing some of pyrazolines in a DES medium. The synthetic application of the present methodology is employed in the synthesis of a pyrazoline alkaloid.

Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and ecologically benign catalyst, was used for the one-pot synthesis of chalcones and 1,3,5-triaryl-2-pyrazolines (TAPs). Chalcones were prepared via the condensation of substituted acetophenones with aryl-aldehydes under solvent-free conditions. Subsequently, the synthesized chalcones were used for the catalytic synthesis of TAPs via two-component condensation with phenyl hydrazine in refluxing ethanol. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate of high purity. Compared to conventional procedures, the present protocol offers several advantages such as simplicity of the procedure, appropriate reaction times, high to excellent yields, easily work-up, recoverability, and reusability of the catalyst, and simple purification of the products.

Iron-catalyzed aerobic oxidative aromatization of 1,3,5-trisubstituted pyrazolines

A simple and high yielding method for the synthesis of tri-substituted pyrazoles via iron(III) catalyzed aerobic oxidative aromatization of pyrazolines has been reported. The process demonstrates a variety of functional group tolerance.

Tungstophosphoric acid supported on highly organosoluble polyamide (PW 12/PA): Highly efficient catalysts for the synthesis of novel 1,3,5-triaryl-2-pyrazoline derivatives

A novel compound constructed from polyoxometalate (H3PW 12O40, PW12) and poly(amidoamine) (PA) was prepared at room temperature in an aqueous solution by an impregnation method. A series of novel 1,3,5-triaryl-2-pyrazoline derivatives was synthesized by the reaction between chalcone and phenylhydrazine in the presence of the title compound, PW12/PA, in high yields. The structures of the compounds obtained were determined by IR and 1H NMR spectra.

Mechanically activated synthesis of 1,3,5-triaryl-2-pyrazolines by high speed ball milling

An efficient mechanically activated solvent-free synthesis of 1,3,5-triaryl-2-pyrazolines from chalcones and phenylhydrazines using high speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time and ne

Synthesis of 4-(diarylpyrazolinyl)phenylmaleimides as thiol-directed fluoroprobes

Synthesis of four N-[4-(diarylpyrazolinyl)phenyl]maleimides and their fluorescence properties are described. Among these, the N-[4-(3,5-diphenyl-2-pyrazolin-1-yl)phenyl]maleimide shows a ten-fold fluorescence enhancement upon thiol addition and forms a fl