6974-51-2

Usage

Uses

Used in Organic Synthesis:
2-naphthalen-1-yl-2-phenyl-acetonitrile is used as a versatile intermediate in organic synthesis for the production of various organic compounds. Its unique structure with a naphthalene ring, phenyl group, and acetonitrile functional group allows for the creation of a wide range of chemical products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-naphthalen-1-yl-2-phenyl-acetonitrile is used as a building block for the development of new drugs. Its structural features make it a valuable component in the synthesis of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
2-naphthalen-1-yl-2-phenyl-acetonitrile is also utilized in the agrochemical sector as a starting material for the synthesis of various agrochemicals. Its properties contribute to the development of effective products for agricultural use.

InChI:InChI=1/C18H13N/c19-13-18(15-7-2-1-3-8-15)17-12-6-10-14-9-4-5-11-16(14)17/h1-12,18H

Upstream product

• 91-20-3 naphthalene 
• 5798-79-8 bromo-phenyl-acetonitrile 
• 532-28-5 (RS)-mandelonitrile 
• 67-66-3 chloroform 
• 7646-78-8 tin(IV) chloride 
• 7677-24-9 trimethylsilyl cyanide 
• 1613376-68-3 tert-butyl (1-naphthyl)(phenyl)methyl carbonate 
• 38262-42-9 1-naphthyl mesylate 
• 140-29-4 phenylacetonitrile 
• 68211-49-4 1-naphthyl tosylate 
• 642-28-4 phenyl(1-naphthyl)methanol 
• 71-43-2 benzene 

Downstream Products

• 39094-08-1 2-(naphthalen-1-yl)-2-phenylacetic acid 

Relevant academic research and scientific papers

Divergent synthesis of isonitriles and nitriles by palladium- catalyzed benzylic substitution with TMSCN

Ligand-controlled palladium-catalyzed divergent synthesis of isonitriles and nitriles from benzylic carbonates and TMSCN has been developed. The BINAP- or DPEphos-ligated palladium catalyst selectively provides the corresponding benzylic isonitriles, wher

Palladium-Catalyzed Direct α-Arylation of Arylacetonitriles with Aryl Tosylates and Mesylates

The first general palladium-catalyzed α-arylation of arylacetonitriles with aryl and heteroaryl sulfonates are reported. Pd(OAc)2 associated with XPhos serves as the effective catalyst to facilitate this reaction. A broad range of electron-rich, -neutral, -deficient, and sterically hindered aryl/heteroaryl tosylates and mesylates are coupled with arylacetonitriles bearing different substituents to give the corresponding products in good to excellent yields. Catalyst loading down to 0.1 mol-% Pd was achieved, and 22 unprecedented compounds were synthesized from 43 demonstrated examples using this method. Its applicability with the modification of biological phenolic compounds was successfully demonstrated. The Pd/XPhos system catalyzed the α-arylation and followed by alkylation in one-pot sequential conditions, resulting in the direct synthesis of compounds containing quaternary center- and deuterium-containing compounds in good to excellent yields.

Palladium-Catalyzed Regiodivergent Substitution of Propargylic Carbonates

The palladium(0)-catalyzed, ligand-controlled, regioselective addition of diaryl acetonitrile pronucleophiles to propargylic carbonates is reported. Selective formation of either terminal 1,3-dienyl or propargylated products is proposed to arise from a change in reaction mechanism controlled by the denticity of the coordinating ligand.