1605320-73-7Relevant academic research and scientific papers
Cu(OAc)2-Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α-Acylmethyl Malonates with Indole Derivatives to Access 3-Functionalized Indoles and Polycyclic Indoles
Zhou, Li-Jin,Wang, Kun,Guan, Hong-Rong,Zheng, An-Qi,Yang, Hai-Tao,Miao, Chun-Bao
, p. 7925 - 7938 (2020)
A Cu(OAc)2-promoted oxidative cross-dehydrogenative coupling reaction of α-acylmethyl malonates with indole derivatives was developed. In the case of indoles, the regioselective coupling products were formed through a sequential dehydrogenation-addition-dehydrogenation process. When a second nucleophilic center was located in the 2-position of indoles, further successive nucleophilic cyclization occurred to give polycyclic indole derivatives. The Cu(OAc)2 was proved to act as not only an oxidant but also a catalyst.
A new tandem synthesis of bis(β,β′-dialkoxy carbonyl) compounds by oxidative cleavage of aziridines under metal-free conditions
Samanta, Satyajit,Santra, Sougata,Chatterjee, Rana,Majee, Adinath
, p. 551 - 556 (2020/01/30)
An efficient and new approach has been developed to synthesize bis(β,β′-dialkoxy carbonyl) derivatives through the reaction between N-tosylaziridines and malonate esters under ambient air using tBuOK in DMSO solvent. A plausible reaction pathway has been predicted. Control experiments suggested that the reactions proceed through the formation of α-aminoketones. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and simple operation. A gram-scale synthesis demonstrates the potential applications of the present method.
A simple and efficient approach to realize difunctionalization of arylketones with malonate esters via electrochemical oxidation
Gao, Huihui,Zha, Zhenggen,Zhang, Zhenlei,Ma, Huanyue,Wang, Zhiyong
supporting information, p. 5034 - 5036 (2014/05/06)
A facile difunctionalization of arylketones with malonate esters via electrochemical oxidation was achieved under mild conditions. A variety of difunctionalized products were obtained in good to excellent yields.
