69827-90-3Relevant academic research and scientific papers
3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES FOR THE TREATMENT OF HCV
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, (2015/11/09)
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either al
Synthesis of 3′-deoxy-3′-C-hydroxymethyl analogues of tiazofurin and ribavirin
Chun, Moon Woo,Kim, Myong Jung,Shin, Ji Hye,Jeong, Lak Shin
, p. 975 - 977 (2007/10/03)
On the basis of potent biological activity of 3′-branched-3′- deoxynucleoside analogues, novel ribavirin and tiazofurin derivatives with 3′-C-hydroxymethyl substituent were synthesized, starting from D-xylose. Copyright Taylor & Francis, Inc.
Synthesis and antiviral evaluation of 2′,3′-dideoxy-2′ -fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl pyrimidine nucleosides
Hassan, Abdalla E. A.,Pai, Balakrina S.,Lostia, Stefania,Stuyver, Lieven,Otto, Michael J.,Schinazi, Raymond F.,Watanabe, Kyoichi A.
, p. 891 - 894 (2007/10/03)
The synthesis and anti-HBV and anti-HIV activity of a number of 2′,3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl-β -D-arabinofuranosyl pyrimidine nucleosides are reported.
Synthesis of novel D- and L-3′-deoxy-3′-C-Hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor
Moon Woo Chun,Myung Jung Kim,Un Hee Jo,Joong Hyup Kim,Kim,Lak Shin Jeong
, p. 703 - 706 (2007/10/03)
D- and L-3′-Deoxy-3′-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2′-position were synthesized, starting from D- and L-xylose as potential ribonucleotide reductase inhibitor, respectively, but they were found to be inactive against several tumor cell lines.
A Ring-Enlarged Oxetanocin A Analogue as an Inhibitor of HIV Infectivity
Tseng, Christopher K-H.,Marquez, Victor E.,Milne, George W. A.,Wysocki, Roland J.,Mitsuya, Hiroaki,et al.
, p. 343 - 349 (2007/10/02)
Two ring-expanded analogues (compounds 2 and 3) of the anti-HIV fermentation product oxetanocin A (1) were synthesized from commercially available diacetone D-glucose.Antiviral testing against HIV in ATH8 cells revealed that the ring-expanded analogue 2 p
