69837-02-1

Basic information

• Product Name: (2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE
• Synonyms: (2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE;(E)-1-(4-methoxyphenyl)-3-(thiophen-2-yl)prop-2-en-1-one;(2E)-1-(4-methoxyphenyl)-3-(thiophen-2-yl)prop-2-en-1-one
• CAS NO: 69837-02-1
• Molecular Formula: C₁₄H₁₂O₂S
• Molecular Weight: 244.31
• Mol File: 69837-02-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 406°C at 760 mmHg
• Flash Point: 199.4°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 8.39E-07mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: (2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE(69837-02-1)
• EPA Substance Registry System: (2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE(69837-02-1)

Safety Data

• Hazardous Substances Data: 69837-02-1(Hazardous Substances Data)

Usage

Description

(2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE, also known as 4'-Methoxychalcone or 4'-Methoxyphenylchalcone, is a chalcone derivative with a molecular formula C14H12O2. It is a yellow crystalline powder that exhibits potential pharmacological properties, such as antioxidant, anti-inflammatory, and anticancer effects. This chemical compound is also used in the synthesis of other organic compounds and as a fluorescent probe in biological research.

Uses

Used in Pharmaceutical Industry:
(2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE is used as a pharmaceutical candidate for its potential antioxidant, anti-inflammatory, and anticancer effects. Its pharmacological properties make it a promising substance for the development of new drugs and therapies.
Used in Organic Synthesis:
(2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE is used as a key intermediate in the synthesis of other organic compounds, contributing to the development of new chemical products and materials.
Used in Biological Research:
(2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE is used as a fluorescent probe in biological research, aiding in the study of various biological processes and mechanisms.
Further research and testing are ongoing to explore the potential applications and properties of (2E)-1-(4-METHOXYPHENYL)-3-(2-THIENYL)PROP-2-EN-1-ONE in various industries.

InChI:InChI=1/C14H12O2S/c1-16-12-6-4-11(5-7-12)14(15)9-8-13-3-2-10-17-13/h2-10H,1H3/b9-8+

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 109980-44-1 4-(4-methoxy-phenyl)-2-oxo-6-[2]thienyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 139435-70-4 2-thienylidene-4'-methoxyacetophenone-5-sulfonyl chloride 
• 139435-71-5 5-[(E)-3-(4-Methoxy-phenyl)-3-oxo-propenyl]-thiophene-2-sulfonic acid diethylamide 
• 1029793-19-8 C₁₅H₁₅N₃OS₂ 
• 1386394-38-2 2-(3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one 
• 929508-25-8 4-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole 
• 929370-26-3 2-(3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole 
• 59035-74-4 3-(4-Methoxy-phenyl)-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole 
• 77607-72-8 2-amino-6-(4-methoxyphenyl)-4-(2-thienyl)nicotinonitrile 
• 133617-61-5 3-cyano-6-(4-methoxyphenyl)-2-methyl-4(2-thienyl)pyridine 
• 87219-68-9 3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole 
• 20264-73-7 3-(4-methoxy-phenyl)-1-phenyl-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole 
• 77607-76-2 3-cyano-4-(2'-thienyl)-6-p-anisyl-2-pyridone 
• 82619-74-7 4-(4-methoxyphenyl)-6-(thiophen-2-yl)pyrimidine-2-amine 

Relevant articles and documents

Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.

Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

A series of sulfur-containing heterocyclic pyrazoline derivatives (C1-C18; D1-D9) have been synthesized and purified (all are new except one) to screen for FabH inhibitory activity. Compound C14 showed the most potent biological activity against Escherich

Studies on the nuclear magnetic resonance spectra of (E)-1-Aryl-3-(2- and 3-thienyl)-2-propenones and unique observation of 4J and 5J coupling in their 1H-1H COSY

1H and 13C NMR spectra of series of (E)-1-aryl-(2- and 3-thienyl)-2-propenones, that are aldol condensation products between 2- and 3-thiophenecarbaldehydes and m- and p-substituted acetophenones, were examined to make complete assig