699-55-8

Usage

Uses

Used in Research and Development:
Bicyclo[2.2.2]octane-1-carboxylic acid serves as a valuable compound in the field of research and development, where it is utilized as a subject of study for its synthesis and properties. Its unique structure and properties make it an intriguing candidate for investigations into the behavior of organic compounds with complex three-dimensional configurations.
Used in Organic Chemistry:
In the realm of organic chemistry, bicyclo[2.2.2]octane-1-carboxylic acid is employed as a building block or intermediate in the synthesis of more complex organic molecules. Its distinctive bicyclic structure provides a foundation for creating novel compounds with potential applications in various industries.
Used in Pharmaceutical Industry:
Although its commercial use is limited, bicyclo[2.2.2]octane-1-carboxylic acid may be utilized in the pharmaceutical industry as a precursor or modifier in the development of new drugs. Its unique structural features could contribute to the design of molecules with specific biological activities or improved pharmacokinetic properties.
Used in Material Science:
In material science, bicyclo[2.2.2]octane-1-carboxylic acid could be explored for its potential to contribute to the development of new materials with specialized properties. Its rigid and stable structure might be leveraged to create materials with enhanced mechanical strength, thermal stability, or other desirable characteristics.

InChI:InChI=1/C9H14O2/c10-8(11)9-4-1-7(2-5-9)3-6-9/h7H,1-6H2,(H,10,11)

Upstream product

• 92017-20-4 4-bromo-bicyclo[2.2.2]octane-1-carboxylic acid ethyl ester 
• 64-18-6 formic acid 
• 2064-02-0 1-(Hydroxymethyl)bicyclo<2.2.1>heptane 
• 74830-48-1 acide bicyclo<2.2.2>octane peroxycarboxylique-1 
• 2574-42-7 bicyclo<2.2.2>octane-1-methanol 
• 3037-84-1 ethyl bicyclo[2.2.2]oct-2-ene-1-carboxylate 
• 3048-85-9 1-Aethoxycarbonyl-bicyclo<2.2.2>octan-2,3-dicarbonsaeure 
• 18720-35-9 bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester 
• 30810-15-2 methyl cyclohexa-1,3-diene-1-carboxylate 
• 2534-81-8 Methyl-bicyclo<2.2.2>oct-2-en-1-carboxylat 
• 15023-45-7 methyl exo-2-bromobicyclo<2.2.1>heptane-1-carboxylate 
• 2534-90-9 exo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid 
• 85173-54-2 exo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid chloride 
• 18720-30-4 norbornane-1-carboxylic acid 

Downstream Products

• 2574-42-7 bicyclo<2.2.2>octane-1-methanol 
• 7363-97-5 bicyclo<2.2.2>octane-1-carboxaldehyde tosylhydrazone 
• 149891-94-1 bicyclo<2.2.2>octane-1-carboxaldehyde-d tosylhydrazone 
• 931-98-6 1-Iodobicyclo<2.2.2>octane 
• 280-33-1 bicyclo[2,2,2]octane 
• 90978-21-5 N-octyl-(1)>-carbaminsaeure-methylester 
• 96454-73-8 bicyclo<2.2.2>octylacetylene 
• 931-98-6 1-bicyclo<2.2.2>octyliodide 
• 79635-09-9 N-Benzylbicyclo<2.2.2>octan-1-carboxamid 
• 131230-08-5 anti-1-Bicyclo<2.2.2>octylmethylketoxim-pikrat 
• 25344-96-1 oct-1-yl-methyl>-amin 
• 1193-42-6 1-aminobicyclo<2.2.2>octane 

Relevant academic research and scientific papers

MITOCHONDRIA-TARGETING PEPTIDES

Disclosed are analogs of SBT-20. The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.

OXAZOLIDINONES AS MODULATORS OF MGLUR5

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.

Oxoammonium salts. 6. 4-Acetylamino-2,2,6,6-tetramethylpiperidine-1- oxoammonium perchlorate: A stable and convenient reagent for the oxidation of alcohols. Silica gel catalysis

4-Acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium perchlorate, 1, is a stable, nonhygroscopic oxoammonium salt that is easily prepared and can be used for the oxidation of alcohols to ketones or aldehydes in near quantitative yields. The reaction is colorimetric, does not require anhydrous conditions, does not involve heavy metals, and can be carried out conveniently. Furthermore, the oxidant can be easily regenerated. The oxidation is somewhat specific in that the relative reactivities of an allyl alcohol (geraniol), benzaldehyde, and 1-decanol are about 100:1:0.1. The reaction is catalyzed by silica gel.

Bicyclonon-1-ene: Matrix Isolation and Spectroscopic Characterization of a Moderately Strained Bridgehead Olefin

Bicyclonon-1-ene was generated in low-temperature matrices and in fluid solutions by photodecomposition of bicyclooct-1-yldiazomethane and its photorearrangement product, 3-(bicyclooct-1-yl)diazirine.It was characterized by IR and UV absorption and by 1H and 13C NMR spectroscopy.Further evidence for the proposed structure was provided by self-trapping and by the spectral effects of deuteration on the olefinic carbon.Observed IR spectra and isotopic shifts agree well with the results of semiempirical (MNDO) and ab initio (SCF/6-31G*) calculations.

Decarboxylation of Bridgehead Carboxylic Acids by the Barton Procedure

Reductive decarboxylation of a series of bicyclic and polycyclic acids in which the carboxyl group is attached to the bridgehead position has been investigated.Conversion of the acids into thiohydroxamic esters occurs via reaction of the derived acid chlorides with N-hydroxypyridine-2-thione.Decomposition of the esters proceeds smoothly in boiling benzene in the presence of 1-butyl mercaptan to give the reduced product in high yield.The procedure appears to be generally applicable, and is unaffected by functional groups such as esters and acetals.

ETUDE DU CARACTERE NUCLEOPHILE DES RADICAUX LORS DE LA REACTION DE TRANSFERT SUR LA LIAISON O-O DES PERACIDES

Peracids RCO3H yield free radicals R. which react either with the peracid or with solvent giving the alcohol ROH and the hydrocarbon RH.The nucleophilic character of the free radicals was modified either by substitution of the carbon bearing the odd electron by inductive groups or by changing the free radical hybridation by the means of blocked structures such as cyclic or bicyclic free radicals.For each R., the measurement of the ratio ROH/RH establishes a reactivity scale for R. with the peracid O-O bond.This reactivity does not depend on free radical stability but depends strongly on nucleophilic character.A primary free radical is less reactive than a secondary one, and is much less reactive than a tertiary one.A bridgehead free radical as the bicycloheptyle-1 does not react with the peracid.These results are interpreted to indicate a transition state with charge transfer (polar effect), the peracid being electrophilic and the free radical nucleophilic; PMO theory is discussed.