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69977-52-2

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69977-52-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 69977-52-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,9,7 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 69977-52:
(7*6)+(6*9)+(5*9)+(4*7)+(3*7)+(2*5)+(1*2)=202
202 % 10 = 2
So 69977-52-2 is a valid CAS Registry Number.

69977-52-2Relevant articles and documents

Evaluation of the antidepressant activity, hepatotoxicity and blood brain barrier permeability of methyl genipin

Che, Xin,Wang, Meiyu,Wang, Tian,Fan, Huaying,Yang, Mingyan,Wang, Wenyan,Xu, Hui

, (2016)

Geniposide (GE) is the main bioactive component of Gardeniae Fructus. The hepatotoxicity of geniposide limited clinical application. In order to get a new geniposide derivative that has less hepatotoxicity and still possesses the antidepressant activity, a new C-1 hydroxyl methylation derivative named methyl genipin (MG) was synthesized from geniposide. In the present study, we demonstrated that MG did not increase the liver index, alanine aminotransferase (ALT) and aspirate aminotransferase (AST). Histopathological examination suggested that no toxic damages were observed in rats treated orally with MG (0.72 mmol/kg). More importantly, a 7-day treatment with MG at 0.13, 0.26, and 0.52 mmol/kg/day could reduce the duration of immobility. It showed that the antidepressant-like effects of MG were similar to GE in the tail suspension test and the forced swim test. Furthermore, we found MG could be detected in the brain homogenate of mice treated orally with MG 0.52 mmol/kg/day for 1 day by HPLC. The area under the curve (AUC) of MG in the brain homogenate was enhanced to 21.7 times that of GE. The brain amount and distribution speed of MG were improved significantly after oral administration. This study demonstrated that MG possessed the antidepressant effects and could cross the blood-brain barrier, but had less hepatotoxicity.

Novel genipin derivatives and preparation method and application thereof

-

Paragraph 0263-0265; 0266-0268, (2021/06/23)

The invention provides novel genipin derivatives and a preparation method thereof. The novel genipin derivatives comprise geniposide derivatives and genipin derivatives. The invention belongs to the field of pharmaceutical chemistry. The geniposide derivative has a structure shown as a formula (I).

Design, synthesis, and evaluation of genipin derivatives for the treatment of Alzheimer's Disease

Huang, Weijun,Wang, Yujun,Li, Jiaming,Zhang, Yanchun,Ma, Xiaodong,Zhu, Panhu,Zhang, Yang

, p. 110 - 122 (2018/12/11)

Twenty-two novel genipin derivatives have been designed, synthesized, and evaluated for their inhibitory activity against acetylcholinesterase (AChE). As a result, compound 13a bearing ligustrazine moiety displayed the most potent AChE inhibitory activity in this series with IC50 value of 218?nm. Besides, MTT assay was performed to investigate the neuroprotection of these compounds against PC12 cells injured by Amyloid β-protein 1–42 (Aβ1–42). Among them, 8a showed higher inhibition rate (%Inhibition?=?22.29) than the positive reference Donepezil (%Inhibition?=?17.65).

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