70-30-4 Hazards Identification
Pictogram(s):
Signal:
Danger
GHS Hazard Statements:
H301: Toxic if swallowed [Danger Acute toxicity, oral]
H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement Codes:
P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501
Hazard Classes and Categories:
Acute Tox. 3 *
Aquatic Acute 1
Aquatic Chronic 1
Acute toxicity - category 3
Reproductive toxicity - category 2
Specific target organ toxicity (single exposure) - category 1
Specific target organ toxicity (repeated exposure) - category 1
Hazardous to the aquatic environment (acute) - category 1
Hazardous to the aquatic environment (chronic) - category 1
Acute toxicity (Oral) - Category 3
Reproductive toxicity - Category 2
Specific target organ toxicity - Single exposure - Category 1 (nervous system, visual system)
Specific target organ toxicity - Repeated exposure - Category 1 (nervous system)
Hazardous to the aquatic environment (Acute) - Category 1
Hazardous to the aquatic environment (Long-term) - Category 1
Hazards Summary:
Hexachlorophene was removed from the over-the-counter market in the 1970s after neurotoxic effects were reported. Studies showed that between 0.3% and 6% of photo patch tested patients were allergic to this substance. [Marks, p. 232-3] Asthma reported in hospital employee; [Malo] In high-dose animal studies, hexachlorophene causes testicular damage and birth defects. [Frazier, p. 271-2] Acute exposure may cause CNS effects; A skin sensitizer; May cause asthma; [ICSC]
70-30-4 Usage
Uses
Used in Healthcare Industry:
2,2'-Methylenebis(3,4,6-trichlorophenol) is used as an antiseptic and disinfectant for its ability to effectively combat a wide range of bacteria and fungi, thereby helping to control infections in healthcare settings.
However, due to its potential toxic effects, including impacts on the central nervous system and the risk of organ damage, as well as its association with environmental hazards and contamination, the use of 2,2'-Methylenebis(3,4,6-trichlorophenol) has been largely phased out in many countries. Consequently, its application in the healthcare industry has been restricted and is now closely regulated to mitigate these risks.
Check Digit Verification of cas no
The CAS Registry Mumber 70-30-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 0 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 70-30:
(4*7)+(3*0)+(2*3)+(1*0)=34
34 % 10 = 4
So 70-30-4 is a valid CAS Registry Number.
70-30-4Relevant academic research and scientific papers
Compositions
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, (2008/06/13)
The problem of providing a storage stable anti-calculus toothpaste comprising a tripolyphosphate salt is remedied by incorporating more than 4% of the salt and having the pH from about 8 to about 10. A tripolyphosphate salt may also be combined with a noncationic anti-bacterial agent such as triclosan to provide a composition having anti-calculus and anti-plaque activity.
Antiplaque oral hygiene composition
-
, (2008/06/13)
An oral hygiene composition in the form of a dentifrice or a mouthwash, comprising: (a) from 0.01 to 2% by weight of the composition of an antibacterial compound of formula (I): STR1 in which R1 is oxygen, sulphur or an alkylene group of from 1 to 6 carbon atoms, each of R2 to R6 and R2 ' to R6 ' is hydrogen, hydroxyl or halogen; (b) from 0 to 90% by weight of a dentally acceptable abrasive, (c) from 0.1% to 15% by weight of a dialkali or tetra-alkali metal pyrophosphate salt or a mixture thereof and (d) water.
Dentifrice compositions
-
, (2008/06/13)
It is disclosed that a dentifrice which includes a surfactant and an anti-plaque agent comprising a substantially water-insoluble non-cationic antimicrobial agent or a zinc salt or a mixture thereof has enhanced activity when the dentifrice comprises at least 0.2% by weight of a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm.
Anticalculus composition
-
, (2008/06/13)
This invention relates to an improved composition for inhibiting dental plaque and calculus formation, comprising zinc ions and a non-toxic, organoleptically acceptable antibacterial agent in an orally acceptable medium, and to a process for retarding the growth of dental plaque and calculus by application to the teeth of the above composition.
