70172-33-7

Basic information

• Product Name: 2-ANILINOPHENYLACETIC ACID
• Synonyms: 2-ANILINOPHENYLACETIC ACID;2-phenylaminophenylacetic acid;phenylamino-2-yl-phenylacetic acid;2-(Phenylamino)benzeneacetic acid;2-[2-(phenylamino)phenyl]acetic acid, 2-(phenylamino)benzeneacetic acid
• CAS NO: 70172-33-7
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Product Categories: Phenylacetic acid
• Mol File: 70172-33-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 89-93 °C(lit.)
• Boiling Point: 407.4 °C at 760 mmHg
• Flash Point: 200.2 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 2.29E-07mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.14±0.10(Predicted)
• CAS DataBase Reference: 2-ANILINOPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ANILINOPHENYLACETIC ACID(70172-33-7)
• EPA Substance Registry System: 2-ANILINOPHENYLACETIC ACID(70172-33-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 70172-33-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 70172-33-7 differently. You can refer to the following data:
1. Biologically active molecule with potential anticonvulsant properties 1 Reactant for: Friedel-Crafts cyclization reactions.
2. Biologically active molecule with potential anticonvulsant propertiesReactant for:Friedel-Crafts cyclization reactions

InChI:InChI=1/C14H13NO2/c16-14(17)10-11-6-4-5-9-13(11)15-12-7-2-1-3-8-12/h1-9,15H,10H2,(H,16,17)

Upstream product

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 18698-97-0 ortho-bromophenylacetic acid 
• 15307-79-6 diclofenac sodium 
• 15307-86-5 [2-(2,6-dichloroanilino)phenyl]acetic acid 
• 353497-35-5 2-[(methoxycarbonyl)phenylamino]benzeneacetic acid 
• 805236-74-2 [2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester 
• 39507-06-7 (2-phenylamino-phenyl)-acetic acid methyl ester 
• 122-39-4 diphenylamine 
• 75385-92-1 (N,N-diphenylcarbamoyl) formyl chloride 
• 5428-43-3 2-chloro-N,N-diphenylacetamide 
• 723-89-7 1-phenyl-indole-2,3-dione 

Downstream Products

• 905836-27-3 2-[2-(phenylamino)phenyl]acetyl chloride 
• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 

Relevant articles and documents

Effective liquid phase hydrodechlorination of diclofenac catalysed by Pd/CeO2

Palladium catalysts supported on Al2O3, activated carbon (AC), SiO2 and CeO2 were prepared using the impregnation and deposition-precipitation methods. The liquid phase catalytic hydrodechlorination of diclofenac on the catalysts was investigated, and the toxicity of the original and treated diclofenac solutions was evaluated using Daphnia magna. Characterization results indicated that the Pd catalyst supported on CeO2 had a higher Pd dispersion than those supported on Al2O3, AC and SiO2. The binding energy of Pd 3d5/2 in Pd/CeO2 was higher than Pd/Al2O3 with a similar Pd loading amount. Additionally, for Pd/CeO2 prepared by the deposition-precipitation method the binding energy of Pd 3d5/2 slightly decreased with the Pd loading amount. As for catalytic diclofenac reduction, Pd/SiO2 exhibited a nearly negligible catalytic activity, whereas diclofenac concentration decreased by 100, 86, and 29% within 50 min of reaction on Pd/CeO2, Pd/Al2O3, and Pd/AC, respectively, indicative of a catalytic activity order of Pd/CeO2 > Pd/Al2O3 > Pd/AC > Pd/SiO2. The hydrodechlorination of diclofenac on Pd/CeO2 could be well described using the Langmuir-Hinshelwood model. Diclofenac hydrodechlorination processed via a combined stepwise and concerted pathway, and increasing Pd loading amount in Pd/CeO2 favoured the concerted pathway. In comparison with original diclofenac, catalytic hydrodechlorination of diclofenac led to markedly decreased toxicity to Daphnia magna.

Design, synthesis and?in?vivo anticonvulsant screening in?mice of?Novel phenylacetamides

A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software. The novel molecules were synthesized and screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Test compounds were found to be potent in MES test. Compounds 12 and 14 were found to be more potent with ED50 values 24.0 and 8.0?mg kg-1, respectively, and their activity was comparable to standard drugs (Phenytoin, Carbamazepine). Test compounds did not show significant activity in ScPTZ test. Compounds 12 and 14 also exhibited higher protective indices (20.3 and 87.5, respectively) when assessed for neurotoxicity by rotarod test as compared to the standards.

A new synthesis of oxcarbazepine using a Friedel-Crafts cyclization strategy

A novel, simple, and straightforward process for the large-scale synthesis of oxcarbazepine, the active ingredient of Trileptal, a medicine for the treatment of epilepsy, has been developed. Starting from readily available 1,3-dihydro-1-phenyl-2H-indol-2-one, a Friedel-Crafts cyclization strategy provides a direct route to the tricyclic framework of the target molecule. Crucial to the success of the strategy was the choice of the proper nitrogen-protecting group.