7020-77-1

Upstream product

• 78-84-2 isobutyraldehyde 
• 62-53-3 aniline 
• 100-65-2 N-Phenylhydroxylamine 
• 98-95-3 nitrobenzene 
• 1227476-15-4 Azobenzene 
• 495-48-7 azoxybenzene 
• 3768-55-6 N-trimethylsilylaniline 
• 100-46-9 benzylamine 
• 78-82-0 Isobutyronitrile 

Downstream Products

• 13206-46-7 2-bromo-2-methylpropanal 
• 78-84-2 isobutyraldehyde 
• 62-53-3 aniline 
• 106-40-1 4-bromo-aniline 
• 117874-96-1 2-isopropyl-2-(phenylamino)acetonitrile 
• 78-82-0 Isobutyronitrile 
• 33685-10-8 (1-Isopropyl-but-3-ynyl)-phenyl-amine 
• 52164-25-7 (2-Methyl-propenyl)-phenyl-trimethylsilanyl-amine 
• 21855-22-1 3-Phenylamino-2-methyl-octen-⁽⁵⁾ 
• 21855-21-0 3-Phenylamino-2-methyl-4-ethyl-hexen-⁽⁵⁾ 
• 54367-87-2 4-Methyl-3-phenylamino-pentanoic acid diethylamide 
• 145909-49-5 α-(1-methylethyl)-N-phenyl-benzenemethanamine 
• 90962-79-1 4-Isopropyl-3,3-dimethyl-1-phenyl-azetidin-2-one 
• 344873-43-4 4-Isopropyl-1,3-diphenyl-azetidin-2-one 

Relevant academic research and scientific papers

Colloid and nanosized catalysts in organic synthesis: XIV. Reductive amination and amidation of carbonitriles catalyzed by nickel nanoparticles

Hydrogenation of carbonitriles catalyzed by nickel nanoparticles in the presence of primary amines led to the predominant formation of unsymmetrical secondary amines. In the presence of secondary amines hydrogenation of nitrites provided enamines as main products. Hydrogenation of nitriles in the presence of formamide or acetamide afforded formyl or acetyl derivatives of primary amines.

Copper(I)-Catalyzed regioselective amination of N -aryl imines using TMSN3 and TBHP: A route to substituted benzimidazoles

A novel and efficient copper-catalyzed amination of N-aryl imines is described. This one-pot, multicomponent reaction, in which imine acts as a directing group by chelating to the metal center, affords a potential route for the transformation of the commercial aryl amines, aldehydes, and azides into valuable benzimidazole structural units with wide substrate scope and diversity. The synthetic and mechanistic aspects are presented.

Formal [4+2]-annulation of vinyl azides with N-unsaturated aldimines

Highly functionalized quinolines and pyridines could be synthesized by BF3?OEt2-mediated reactions of vinyl azides with N-aryl and N-alkenyl aldimines, respectively. The reaction mechanism could be characterized as formal [4+2]-annulation, including unprecedented enamine-type nucleophilic attack of vinyl azides to aldimines and subsequent nucleophilic cyclization onto the resulting iminodiazonium ion moieties.

Seven-component reactions by sequential chemoselective Ugi-Mumm/Ugi-Smiles reactions

A seven-component reaction was accomplished by utilizing the different chemoselectivities of the Ugi-Mumm and the Ugi-Smiles reaction. The sequential multicomponent reactions led to highly diverse peptide and glycopeptide like structures.

Synthetic method for the preparation of 2-aminomethyl-1,3-diene derivatives through indium-mediated 1,3-butadien-2-ylation of imines

An efficient method for the preparation of a variety of 2-aminomethyl-1,3-dienes was developed through the reaction of imines with organoindium reagent generated in situ from indium and 1,3-dibromo-2-butyne. Three-component reactions of aldehydes, amines,

A novel four-component synthesis of N-substituted amino acid esters

A library of N-substituted amino acid esters was synthesized using a solid phase bound organic isocyanide that provides a C1 synthon to the final molecule. This novel four-component, one-pot reaction delivers the final products in acceptable yields with high purities of the crude reaction products, facilitating the final purification. The preparation of the isocyano resin is also described the intermediates being controlled by ATR-spectroscopy.

A new protocol for a one-pot synthesis of α-amino phosphonates by reaction of imines prepared in situ with trialkylphosphites

Imines prepared in situ by reaction of aldehydes and ketones with primary amines in ethereal solution of LiClO4 react readily at ambient temperature with trialkylphosphite to give high yields of α-amino phosphonates.

A simple one-pot three-component reaction for preparation of secondary amines and amino esters mediated by lithium perchlorate

The one-pot synthesis of several secondary amines and secondary amino esters are reported. Treatment of aldehydes (aliphatic or aromatic) with (trimethylsilyl)alkylamines, in the presence of 5 M lithium perchlorate in diethyl ether gives intermediate imines. Reaction of these intermediate imines with different nucleophiles and functionalized organozinc reagents, BrZnCH2COOR, produce a variety of secondary amines and N-alkyl- or N-arylamino esters in good yields.

Sodium borohydride on wet clay: Solvent-free reductive amination of carbonyl compounds using microwaves

A solvent-flee reductive amination of carbonyl compounds by wet montmorillonite K 10 clay supported sodium borohydride is described; microwave irradiation facilitates the procedure.

Effect of the structure of the carrier on the catalytic properties of palladium-containing ion exchangers

We discuss the effect of the nature of the functional group of the polymeric carrier (anion exchanger) on the catalytic activity of palladium-containing anion exchangers towards hydrogenation reactions.