70301-27-8

Basic information

• Product Name: N-(2-methoxyphenyl)nicotinamide
• Synonyms: N-(2-methoxyphenyl)nicotinamide;N-(2-Methoxyphenyl)-3-pyridinecarboxamide;3-PyridinecarboxaMide, N-(2-Methoxyphenyl)-
• CAS NO: 70301-27-8
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.24658
• Mol File: 70301-27-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 305℃
• Flash Point: 139℃
• Appearance: /
• Density: 1.230
• Storage Temp.: 2-8°C
• PKA: 11.65±0.70(Predicted)
• CAS DataBase Reference: N-(2-methoxyphenyl)nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxyphenyl)nicotinamide(70301-27-8)
• EPA Substance Registry System: N-(2-methoxyphenyl)nicotinamide(70301-27-8)

Safety Data

• Hazardous Substances Data: 70301-27-8(Hazardous Substances Data)

Usage

General Description

N-(2-methoxyphenyl)nicotinamide is a chemical compound that is a combination of nicotinamide (a form of vitamin B3) and 2-methoxyphenyl, a derivative of phenol. It is often used in medicinal and pharmaceutical applications due to its potential antioxidant and anti-inflammatory properties, and its ability to inhibit the production of prostaglandins, which are involved in pain and inflammation. Additionally, it has been studied for its potential effects on improving skin conditions such as acne and aging, as well as its potential application in treating certain types of cancer. N-(2-methoxyphenyl)nicotinamide also has potential uses in the development of new drugs and treatments for various diseases and conditions.

Upstream product

• 59-67-6 nicotinic acid 
• 90-04-0 2-methoxy-phenylamine 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 578-57-4 2-bromoanisole 
• 98-92-0 nicotinamide 
• 529-28-2 4-iodoanisol 
• 10400-19-8 3-pyridinecarbonyl chloride 

Relevant articles and documents

Method for preparing amide compound by photocatalysis of organic amine

The invention relates to the technical field of organic synthesis, in particular to a method for preparing amide compounds through photocatalysis of organic amine. The preparation method comprises the following steps: mixing tetrahalomethane with a solvent, sequentially adding an amine compound, a catalyst and organic carboxylic acid, performing stirring and reacting under an oxygen-containing atmosphere and an illumination condition, and performing separating and purifying to obtain the amide compound with a structure shown in formulas V-VII. According to the method, the reaction is carried out in the air atmosphere under the illumination condition at room temperature and normal pressure, the reaction condition is mild, the raw material source is wide, the cost is low, the byproduct generated after the reaction is the halogen simple substance, the added value is high, a large amount of waste is avoided, and the method has higher atom economy and environmental friendliness and is beneficial to large-scale production.

Iron-catalyzed N-arylations of amides

A method was proposed for iron-catalyzed N-arylation of primary amides and its applicability to the synthesis of N-heterocycles by intramolecular ring closures. The method used a catalyst system of 10 mol % of FeCl3 and 20 mol % of N,N'-dimethylethylenediamine (DMEDA). The study found that secondary amides of N-methylbenzamide and N-benzylbenzamide produce N-arylated products in trace amounts. The method developed an iron-based catalyst system for efficient N-arylations of primary amides with aryl iodides. The study used a sealable tube equipped with a magnetic stir bar charged with amide, or K 3PO4, or K2CO3, or FeCl3. The study used NMR spectroscopic analysis to determine the identity and purity of the products. The method observed that different substituted aryl iodides made a positive impact on the reaction.

Structure and antiinflammatory activity of isonicotinic and nicotinic amides

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