70301-27-8

Usage

Uses

Used in Pharmaceutical Applications:
N-(2-methoxyphenyl)nicotinamide is used as a pharmaceutical agent for its potential antioxidant and anti-inflammatory properties, which can be beneficial in the treatment of various conditions characterized by inflammation and oxidative stress.
Used in Skin Care Industry:
In the skin care industry, N-(2-methoxyphenyl)nicotinamide is used as an active ingredient for improving skin conditions such as acne and signs of aging. Its properties may contribute to reducing inflammation and promoting skin health.
Used in Cancer Treatment Research:
N-(2-methoxyphenyl)nicotinamide is used as a subject of research in oncology for its potential effects on certain types of cancer. It is being studied for its ability to inhibit processes that contribute to tumor growth and progression.
Used in Drug Development:
In the field of drug development, N-(2-methoxyphenyl)nicotinamide is used as a compound of interest for the creation of new treatments for a range of diseases and conditions, leveraging its diverse biological activities.

Upstream product

• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 90-04-0 2-methoxy-phenylamine 
• 578-57-4 2-bromoanisole 
• 98-92-0 nicotinamide 
• 529-28-2 4-iodoanisol 
• 59-67-6 nicotinic acid 
• 10400-19-8 3-pyridinecarbonyl chloride 

Relevant academic research and scientific papers

Method for preparing amide compound by photocatalysis of organic amine

The invention relates to the technical field of organic synthesis, in particular to a method for preparing amide compounds through photocatalysis of organic amine. The preparation method comprises the following steps: mixing tetrahalomethane with a solvent, sequentially adding an amine compound, a catalyst and organic carboxylic acid, performing stirring and reacting under an oxygen-containing atmosphere and an illumination condition, and performing separating and purifying to obtain the amide compound with a structure shown in formulas V-VII. According to the method, the reaction is carried out in the air atmosphere under the illumination condition at room temperature and normal pressure, the reaction condition is mild, the raw material source is wide, the cost is low, the byproduct generated after the reaction is the halogen simple substance, the added value is high, a large amount of waste is avoided, and the method has higher atom economy and environmental friendliness and is beneficial to large-scale production.

Direct synthesis of primary arylamines via C-N cross-coupling of aryl bromides and triflates with amides

Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100-150 °C without solvent, and with low catalyst levels (0.12 mol % Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction.

Iron-catalyzed N-arylations of amides

A method was proposed for iron-catalyzed N-arylation of primary amides and its applicability to the synthesis of N-heterocycles by intramolecular ring closures. The method used a catalyst system of 10 mol % of FeCl3 and 20 mol % of N,N'-dimethylethylenediamine (DMEDA). The study found that secondary amides of N-methylbenzamide and N-benzylbenzamide produce N-arylated products in trace amounts. The method developed an iron-based catalyst system for efficient N-arylations of primary amides with aryl iodides. The study used a sealable tube equipped with a magnetic stir bar charged with amide, or K 3PO4, or K2CO3, or FeCl3. The study used NMR spectroscopic analysis to determine the identity and purity of the products. The method observed that different substituted aryl iodides made a positive impact on the reaction.

Proteomimetic compounds and methods

The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.

AN UNUSUAL SYNTHESIS OF NICOTINAMIDES

Reaction of 2,3-pyridinedicarboxylic anhydride (1) with a substituted aniline (2) in acetic acid gave rise to a mixture of two products.These two products were identified as the cyclic imide (4) and nicotinamide (5).A mechanistic scheme consistent with empirical observations is proposed.