7036-98-8Relevant academic research and scientific papers
Catalytic Upgrading of Biomass-Derived Methyl Ketones to Liquid Transportation Fuel Precursors by an Organocatalytic Approach
Sankaranarayanapillai, Shylesh,Sreekumar, Sanil,Gomes, Joseph,Grippo, Adam,Arab, George E.,Head-Gordon, Martin,Toste, F. Dean,Bell, Alexis T.
supporting information, p. 4673 - 4677 (2015/04/14)
A highly efficient water-tolerant, solid-base catalyst for the self-condensation of biomass-derived methyl ketones to jet-diesel fuel precursors was developed by grafting site-isolated secondary amines on silica-alumina supports. It is shown that apart from the nature and density of amine groups and the spatial separation of the acidic and basic sites, the acidity of the support material plays a critical role in defining the catalytic activity. It is also found that a combination of weakly acidic silanol/aluminol with secondary amine groups can mimic proline catalysts and are more effective in catalyzing the selective dimerization reaction than the combination of amines with organic acids. In situ FTIR measurements demonstrate that acidic groups activate methyl ketones through their carbonyl groups leading to a favorable C - C bond formation step involving an enamine intermediate. DFT analysis of the reaction pathway confirms that C - C bond formation is the rate-limiting step.
Stereospecific Alkylation of 3,5,5-Trisubstituted-4-hydroxy-1-p-tosyl-2-pyrazolines by Trimethylaluminum. An Efficient Synthesis of 3,3,5,5-Tetrasubstituted-1-pyrazolin-4-ones
Pirkle, William H.,Hoover, Dennis J.
, p. 3407 - 3413 (2007/10/02)
Isomeric p-tosylpyrazolines 5 and 6 are obtained in high yield by cyclization of the tosylhydrazones of various β,β-disubstituted-α,β-epoxy ketones 4.Oxidation of these mixtures to pyrazolones 9 followed by selective reduction affords isomers 5.Reaction o
