7039-50-1

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-5-chloro-diphenyl methanol serves as a key building block in the synthesis of various pharmaceuticals. It is utilized for its potential in treating a range of diseases, including cancer and infectious diseases, due to its inherent bioactivity and chemical properties that can be further modified during synthesis.
Used in Agrochemical Industry:
In the agrochemical sector, 2-amino-5-chloro-diphenyl methanol is employed as a starting material for the development of new agrochemicals. Its potential applications extend to enhancing crop protection and yield through its antibacterial and antifungal properties, making it a valuable asset in the creation of effective and targeted treatments for agricultural use.
Used in Medicinal Chemistry Research:
2-amino-5-chloro-diphenyl methanol is also used as a subject of study in medicinal chemistry. Researchers investigate its properties and interactions to explore new avenues for drug discovery and development, focusing on its potential to contribute to the creation of novel therapeutic agents and chemical entities with specific medicinal applications.

Upstream product

• 100-52-7 benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 60794-27-6 (5-chloro-2-nitro-phenyl)-phenyl-methanol 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 1159372-20-9 (2-amino-5-chlorophenyl)(phenyl)methanol 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 

Downstream Products

• 13213-93-9 1-benzoyl-6-chloro-4-phenyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 13213-97-3 6-chloro-1-(2-diethylamino-ethyl)-4-phenyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 13213-92-8 6-chloro-1-(4-chloro-benzoyl)-4-phenyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 13386-34-0 6-chloro-1-[3-(4-methyl-piperazin-1-yl)-propyl]-4-phenyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 30169-34-7 6-chloro-2,4-diphenyl-quinazoline 
• 4015-28-5 6-chloro-4-phenylquinazoline 
• 1171122-81-8 Br^(1-)*C₃₁H₂₆ClNP⁽¹⁺⁾ 
• 132735-20-7 6-Chloro-2-ethylthio-3,4-diphenyl-3H-3,4-dihydroquinazoline hydroiodide 
• 132735-17-2 6-Chloro-2-ethylthio-4-phenyl-1H-3,4-dihydroquinazoline hydroiodide 
• 120075-95-8 6-Chloro-2-methylthio-4-phenyl-1H-3,4-dihydroquinazoline hydroiodide 
• 64820-66-2 6-chloro-4-phenyl-3,4-dihydro-1H-quinazolin-2-one 
• 82562-66-1 2-(6-Chloro-4-phenyl-4H-benzo[d][1,3]oxazin-2-yl)-phenol 

Relevant academic research and scientific papers

Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling

A convenient approach to assemble 1,2,3-triazole-fused 4 H -3,1-benzoxazines has been developed. Diverse alcohol-tethered 5-iodotriazoles, readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles. The intramolecular C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na 2CO 3in acetonitrile at 100 °C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

Ruthenium complexes of phosphine-amide based ligands as efficient catalysts for transfer hydrogenation reactions

This work presents three mononuclear Ru(ii) complexes of tridentate phosphine-carboxamide based ligands providing a NNP coordination environment. The octahedral Ru(ii) ion shows additional coordination with co-ligands; CO, Cl and CH3OH. All three Ru(ii) complexes were thoroughly characterized including their crystal structures. These Ru(ii) complexes were utilized as catalysts for the transfer hydrogenation of assorted carbonyl compounds, including some challenging biologically relevant substrates, using isopropanol as the hydrogen source. The binding studies illustrated the coordination of the isopropoxide ion by replacing a Ru-ligated chloride ion followed by the generation of the Ru-H intermediate that was isolated and characterized and was found to be involved in the catalysis.

An efficient iron-promoted synthesis of 6H-indolo[2,3- b] quinolines and neocryptolepine derivatives

A facile and practical method for the preparation of 6H-indolo[2,3-b]quinolines and neocryptolepines was developed under the promotion of the easily available ferric trichloride, affording the desired products with moderate to good yields.

A simple route to polysubstituted indoles exploiting azide induced furan ring opening

A straightforward, efficient indole synthesis based on thermolysis of 2-(2-azidobenzyl)furans with attack of the formed nitrene moiety onto the ipso position of furan ring has been developed. The cyclization is accompanied by furan ring opening and affords indoles with a 2-acylvinyl substituent suitable for further modifications.

Metal-free intramolecular oxidative decarboxylative amination of primary α-amino acids with product selectivity

A novel metal-free intramolecular oxidative decarboxylative coupling of primary α-amino acids with 2-aminobenzoketones under mild and neutral conditions was developed. Different quinazolines can be selectively obtained by various oxidants.

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.

A simple and efficient approach to the synthesis of 2-phenylquinazolines via sp3 C-H functionalization

(Figure presented) A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp 3 C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.

A novel and efficient methodology for the construction of quinazolines based on supported copper oxide nanoparticles

A series of quinazolines were synthesized from 2-aminobenzophenones and benzylic amines in good to excellent yields by employing a new heterogeneous catalyst based on the copper oxide nanoparticles supported on kaolin.

An enantiopure galactose oxidase model: synthesis of chiral amino alcohols through oxidative kinetic resolution catalyzed by a chiral copper complex

An enantiopure galactose oxidase (GO) enzyme model has been synthesized from readily available (R)-BINAM and Cu(OTf)2, and the enantiopure GO model has been effectively used in situ as an efficient chiral catalyst for the synthesis of chiral amino alcohols through oxidative kinetic resolution (OKR), where molecular oxygen is used as the sole oxidant. Under the proposed catalytic conditions, both ortho- and para-substituted amino alcohols were resolved with good to excellent enantiomeric excesses through oxidative kinetic resolution.

A flexible synthesis of 2,3-disubstituted indoles from aminobenzyl phosphonium salts. A direct synthesis of rutaecarpine

(Chemical Equation Presented) The reaction of substituted (2-aminobenzyl)triphenylphosphonium bromides with aromatic aldehydes or α,β-unsaturated aldehydes constitutes a new synthesis of 2,3-disubstitued indoles in high yields. The adduct from 4-oxo-3,4- dihydroquinazoline-2-carbaldehyde was an advanced intermediate in the synthesis of several rutaecarpines.