70415-50-8 Usage
Description
6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide is an organic compound characterized by its pale yellow solid appearance. It is an intermediate in the synthesis of Lornoxicam, a pharmaceutical agent with analgesic and anti-inflammatory properties.
Uses
Used in Pharmaceutical Industry:
6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide is used as an intermediate in the production of Lornoxicam. 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide serves as a crucial component in the synthesis process, enabling the creation of an effective analgesic and anti-inflammatory agent.
As an intermediate, 6-Chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester 1,1-dioxide plays a significant role in the development of Lornoxicam, which is utilized for the management of pain and inflammation in various conditions. Its chemical properties and structure contribute to the overall efficacy and safety of the final pharmaceutical product.
Check Digit Verification of cas no
The CAS Registry Mumber 70415-50-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,4,1 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 70415-50:
(7*7)+(6*0)+(5*4)+(4*1)+(3*5)+(2*5)+(1*0)=98
98 % 10 = 8
So 70415-50-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H8ClNO5S2/c1-11-6(9(13)16-2)7(12)8-4(18(11,14)15)3-5(10)17-8/h3,12H,1-2H3
70415-50-8Relevant articles and documents
Method for synthesizing lornoxicam intermediate by one-pot method
-
Paragraph 0032-0041, (2018/07/30)
The invention belongs to the technical field of drug synthesis, and in particular relates to a method for synthesizing a lornoxicam intermediate by a one-pot method. The method is as follows: using 5-chloro-3-methylsulfonamidethiophene-2-carboxylic acid methyl ester as a raw material, and adding methyl bromoacetate and sodium methoxide for alkylation reaction; adding again the sodium methoxide forcyclization reaction to obtain 6-chloro-4-hydroxy-2-methyl-2H-thieno [2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide. The lornoxicam intermediate is synthesized by the one-pot methodby alkylation and cyclization two-step reaction, use of dangerous reagents such as dimethyl sulfate and sodium hydride can be avoided, no dangerous gas is produced during the reaction, side reactionsare reduced, production environment is improved, production safety is ensured, operation is simplified, and product yield is improved.