70628-23-8

Upstream product

• 51229-51-7 4-acetylbenzyl bromide 
• 108-95-2 phenol 
• 99-91-2 para-chloroacetophenone 
• 100-66-3 methoxybenzene 
• 431-03-8 dimethylglyoxal 
• 99-90-1 para-bromoacetophenone 
• 1746-13-0 allyl phenyl ether 

Downstream Products

• 219869-73-5 2-benzyl-1-(4-phenoxymethyl-phenyl)-3-phenyl-propan-1-one 
• 1225227-19-9 1-(4-benzyloxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione 
• 219869-78-0 2-[4-(2-benzyl-3-phenyl-propionyl)-benzyl]-3-[4-(2-benzyl-3-phenyl-propionyl)-phenyl]-1-(4-phenoxymethyl-phenyl)-propan-1-one 
• 219869-84-8 2-[4-(2-benzyl-3-phenyl-propionyl)-benzyl]-3-[4-(2-benzyl-3-phenyl-propionyl)-phenyl]-1-(4-hydroxymethyl-phenyl)-propan-1-one 
• 219869-81-5 2-[4-(2-benzyl-3-phenyl-propionyl)-benzyl]-3-[4-(2-benzyl-3-phenyl-propionyl)-phenyl]-1-(4-bromomethyl-phenyl)-propan-1-one 
• 219869-80-4 2-benzyl-1-(4-bromomethyl-phenyl)-3-phenyl-propan-1-one 

Relevant academic research and scientific papers

Metal-Free and Redox-Neutral Conversion of Organotrifluoroborates into Radicals Enabled by Visible Light

Converting organoboron compounds into the corresponding radicals has broad synthetic applications in organic chemistry. To achieve these transformations, various strong oxidants such as Mn(OAc)3, AgNO3/K2S2O8, and Cu(OAc)2, in stoichiometric amounts are required, proceeding by a single-electron transfer mechanism. Established herein is a distinct strategy for generating both aryl and alkyl radicals from organotrifluoroborates through an SH2 process. This strategy is enabled by using water as the solvent, visible light as the energy input, and diacetyl as the promoter in the absence of any metal catalyst or redox reagent, thereby eliminating metal waste. To demonstrate its synthetic utility, an efficient acetylation to prepare valuable aryl (alkyl) methyl ketones is described and applications to construct C?C, C?I, C?Br, and C?S bonds are also feasible. Experimental evidence suggests that triplet diacetyl serves as the key intermediate in this process.

Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation

A new and general method to functionalize the C(sp3)-C(sp2) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to undergo Ni-catalyzed C(sp3)-C(sp2) cross-coupling. This one-pot protocol leverages the easily procured alkene feedstocks for organic synthesis with excellent functional group compatibility without the need for a photoredox catalyst.

CARBAMATE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Direct C(sp3)-H Cross Coupling Enabled by Catalytic Generation of Chlorine Radicals

Here we report the development of a C(sp3)-H cross-coupling platform enabled by the catalytic generation of chlorine radicals by nickel and photoredox catalysis. Aryl chlorides serve as both cross-coupling partners and the chlorine radical source for the α-oxy C(sp3)-H arylation of cyclic and acyclic ethers. Mechanistic studies suggest that photolysis of a Ni(III) aryl chloride intermediate, generated by photoredox-mediated single-electron oxidation, leads to elimination of a chlorine radical in what amounts to the sequential capture of two photons. Arylations of a benzylic C(sp3)-H bond of toluene and a completely unactivated C(sp3)-H bond of cyclohexane demonstrate the broad implications of this manifold for accomplishing numerous C(sp3)-H bond functionalizations under exceptionally mild conditions.

PESTICIDAL SUBSTITUTED PHENYLETHERS

The invention relates to the use of phenylether derivatives of formula (I), to compositions thereof for the control of pests, including arthropods and helminths.

Alkylation of enolates: A new approach to dendrons

The synthesis of new polyketonic dendrons is described. These compounds are representative of a new connectivity in dendrimers. The alkylation of enolates and easy functional group interconversion reactions provides a versatile and efficient procedure for the synthesis of this kind of dendron.