70732-86-4

Upstream product

• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 73-66-5 5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine 
• 52164-53-1 (4-amino-2-methyl-pyrimidin-5-ylmethyl)-dicarbothioamidoic acid-(1-acetyl-3-hydroxy-propyl ester) 
• 55289-66-2 3-Mercapto-4-oxopentyl Acetate 
• 1886-34-6 2-methyl-4-amino-5-formylaminomethylpyrimidine 
• 13045-13-1 3-chloro-3-acetylpropanol 
• 13051-49-5 5-Acetoxy-3-chloropentan-2-one 
• 7732-18-5 water 
• 24361-62-4 1-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-pyridinium; chloride-hydrochloride 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 50596-94-6 4-chloro-5-methyl-2,3-dihydro-furan 
• 64-18-6 formic acid 
• 31375-20-9 4-Amino-2-methyl-5-thioformamidomethylpyrimidin 

Downstream Products

• 1476-77-3 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(2-benzyldisulfanyl-4-hydroxy-1-methyl-but-1-enyl)-formamide 
• 129681-12-5 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-5-(2-phosphonooxy-ethyl)-thiazolium; hydrochloride 
• 19498-76-1 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-phenyldisulfanyl-but-1-enyl)-formamide 
• 111296-37-8 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-p-tolyldisulfanyl-but-1-en-t-yl)-formamide 
• 124357-48-8 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-[2-(2,4-dinitro-phenylsulfanyl)-4-hydroxy-1-methyl-but-1-en-t-yl]-formamide 
• 992-46-1 Thiamin-disulfid-monophosphat 
• 3486-94-0 bis-{2-[(4-amino-2-methyl-pyrimidin-5-ylmethyl)-formyl-amino]-1-(2-benzenesulfonyloxy-ethyl)-trans-propenyl}-disulfide 
• 863-91-2 4-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-6-(2-benzoyloxy-ethyl)-5-methyl-2-phenyl-4H-[1,4]thiazin-3-one 
• 112688-35-4 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-benzoyloxy-1-methyl-2-methyldisulfanyl-but-1-en-t-yl)-formamide 
• 55173-55-2 N-(4-acetoxy-2-benzyldisulfanyl-1-methyl-but-1-en-t-yl)-N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-formamide 
• 24722-56-3 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-benzoyloxy-1-methyl-2-propyldisulfanyl-but-1-en-t-yl)-formamide 
• 118764-71-9 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-benzoyloxy-2-butyldisulfanyl-1-methyl-but-1-en-t-yl)-formamide 
• 16028-14-1 thiamine monophosphate chloride hydrochloride 
• 1610458-99-5 4-(thiamine)phthalonitrile 

Relevant academic research and scientific papers

Synthetic process for chlorinated thiazole onium hydrochloride

The invention provides a synthetic process for chlorinated thiazole onium hydrochloride. The synthetic process includes the following steps that sulfo-thiamine hydrochloride and hydrochloric acid are added into a three-neck flask, and then the flask is put into a freezing tank and cooled to minus 10 DEG C; hydrogen peroxide is added slowly, and the temperature is controlled to be minus 10 DEG C; after addition of hydrogen peroxide is finished, reaction is carried out for 20 h on the heat preservation condition; after heat preservation is finished, chlorinated thiazole onium hydrochloride is filtered, separated out, cleaned with methyl alcohol and dried to obtain the finished chlorinated thiazole onium hydrochloride product. The synthetic process has the advantages of shortening the process route, saving reaction time, reducing production cost, reducing discharge of salt-bearing wastewater and the like.

METHOD FOR PREPARATION OF THIAZOLE DERIVATIVES

A method for the preparation of a thiazole compound of formula (I) comprises reacting a compound of formula (II) with a compound of formula (III) in a solvent containing formic acid.

Method for treating fibrotic diseases or other indications IC

Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:

Controlled release pharmaceutical preparation

A controlled release pharmaceutical preparation comprising a core containing a medicinal compound and a coating layer containing a water-repellent salt and a water-insoluble and slightly water-permeable acrylic polymer having trimethylammoniumethyl group. Said preparation releases a medicinal compound in a sigmoid type dissolution pattern irrespective of the PH of a dissolution medium.