71146-13-9

Basic information

• Product Name: dimethyl 2-(4-methoxyphenyl)malonate
• Synonyms: dimethyl 2-(4-methoxyphenyl)malonate;1,3-dimethyl 2-(4-methoxyphenyl)propanedioate
• CAS NO: 71146-13-9
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.23656
• EINECS: -0
• Mol File: 71146-13-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 170-180 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.170±0.06 g/cm3(Predicted)
• PKA: 12.71±0.46(Predicted)
• CAS DataBase Reference: dimethyl 2-(4-methoxyphenyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-(4-methoxyphenyl)malonate(71146-13-9)
• EPA Substance Registry System: dimethyl 2-(4-methoxyphenyl)malonate(71146-13-9)

Safety Data

• Hazardous Substances Data: 71146-13-9(Hazardous Substances Data)

Usage

Description

Dimethyl 2-(4-methoxyphenyl)malonate is a chemical compound characterized by the molecular formula C11H12O5. It is a colorless liquid that serves as a versatile intermediate in the synthesis of a variety of organic compounds. Known for its reactivity with a broad spectrum of reagents and its capacity for diverse chemical transformations, this compound is a valuable building block for the creation of an array of molecules. Its applications extend across several industries, including pharmaceuticals, chemical, fragrance and flavoring production, medicinal chemistry, and agrochemicals.

Uses

Used in Pharmaceutical and Chemical Industries:
Dimethyl 2-(4-methoxyphenyl)malonate is utilized as a synthetic intermediate for the production of various organic compounds, contributing to the development of new pharmaceuticals and chemical products.
Used in Fragrance and Flavoring Production:
dimethyl 2-(4-methoxyphenyl)malonate is employed as a key ingredient in the creation of fragrances and flavorings, enhancing the sensory profiles of consumer products.
Used in Medicinal Chemistry:
Dimethyl 2-(4-methoxyphenyl)malonate is used as a building block in the development of new drugs, leveraging its chemical properties to construct molecules with potential therapeutic applications.
Used in Agrochemical Industry:
It is applied in the design and synthesis of innovative pesticides and herbicides, aiming to improve agricultural productivity and crop protection.

Upstream product

• 553-90-2 Dimethyl oxalate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 100-66-3 methoxybenzene 
• 108-59-8 malonic acid dimethyl ester 
• 67-56-1 methanol 
• 616-38-6 carbonic acid dimethyl ester 
• 6773-29-1 dimethyl diazomalonate 

Relevant articles and documents

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and codelet

Thermolysis of 2-diazo-3-aryl ketoesters: New route to α-aryl malonates and aromatic esters

Thermochemical excitation enabled efficient α-aryl malonates synthesis from 2-diazo-3-aryl ketoesters and alcohols under transition metal-free reaction conditions. Furthermore, an unusual C[sbnd]C bond cleavage and C[sbnd]O/(N) bond formation occurred whe

Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds

The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.