71162-44-2

Basic information

• Product Name: 1-Heptanone, 1-(4-chlorophenyl)-
• CAS NO: 71162-44-2
• Molecular Formula: C13H17ClO
• Molecular Weight: 224.73
• Mol File: 71162-44-2.mol

Chemical Properties

• CAS DataBase Reference: 1-Heptanone, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Heptanone, 1-(4-chlorophenyl)-(71162-44-2)
• EPA Substance Registry System: 1-Heptanone, 1-(4-chlorophenyl)-(71162-44-2)

Safety Data

• Hazardous Substances Data: 71162-44-2(Hazardous Substances Data)

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 2528-61-2 Heptanoic acid chloride 
• 3761-92-0 n-hexylmagnesium bromide 
• 122-01-0 4-chloro-benzoyl chloride 
• 42599-18-8 (E)-1-hexenyldihydroxyborane 
• 104-88-1 4-chlorobenzaldehyde 
• 592-41-6 1-hexene 

Downstream Products

• 94147-54-3 1-(4-Chloro-phenyl)-2-hydroxy-2-[1,2,4]triazol-1-ylmethyl-heptan-1-one 
• 93307-03-0 1.1-Dichlor-1-<4-chlor-phenyl>-heptan 
• 92017-74-8 1-Chlor-1-<4-chlor-phenyl>-hepten-(1) 

Relevant articles and documents

Selective iron-catalyzed cross-coupling reactions of Grignard reagents with enol triflates, acid chlorides, and dichloroarenes

Cheap, readily available, air stable, nontoxic, and environmentally benign iron salts such as Fe(acac)3 are excellent precatalysts for the cross-coupling of Grignard reagents with alkenyl triflates and acid chlorides. Moreover, it is shown that dichloroarene and -heteroarene derivatives as the substrates can be selectively monoalkylated by this method. All cross-coupling reactions proceed very rapidly under notably mild conditions and turned out to be compatible with a variety of functional groups in both reaction partners. A detailed analysis of the preparative results suggests that iron-catalyzed C-C bond formations can occur via different pathways. Thus, it is likely that reactions of methylmagnesium halides involve iron-ate complexes as the active components, whereas reactions of Grignard reagents with two or more carbon atoms are effected by highly reduced iron-clusters of the formal composition [Fe(MgX)2]n generated in situ. Control experiments using the ate-complex [Me4Fe]Li2 corroborate this interpretation.

Inter- and intramolecular additions of 1-alkenylboronic acids or esters to aldehydes and ketones catalyzed by rhodium(I) complexes in basic, aqueous solutions

Grignard-type addition reaction of 1-alkenylboronic acids or their esters to aldehydes or ketones were carried out in aqueous MeOH or DME in the presence of KOH (1 equivalent) and an RhCl(dppf) or Rh(OH)(dppf) catalyst (3 mol%). The utility of the protocol was demonstrated in the corresponding intramolecular reaction giving cyclic homoallylic alcohols.

Preparation and reactivity of functionalized aryl and alkenylmanganese halides

Various functionalized aryl and alkenyl manganese halides have been prepared from the corresponding aryl and alkenylhalides according to a one-pot procedure: lithium-halogen exchange at low temperature then Li-Mn transmetallation.