71193-46-9

Basic information

• Product Name: 4-Methoxy-N-(3-phenylpropyl)aniline
• Synonyms: 4-Methoxy-N-(3-phenylpropyl)aniline
• CAS NO: 71193-46-9
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.32816
• Mol File: 71193-46-9.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Methoxy-N-(3-phenylpropyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-N-(3-phenylpropyl)aniline(71193-46-9)
• EPA Substance Registry System: 4-Methoxy-N-(3-phenylpropyl)aniline(71193-46-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 71193-46-9(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 104-94-9 4-methoxy-aniline 
• 2038-57-5 3-Phenylpropan-1-amine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 501-52-0 3-Phenylpropionic acid 
• 18437-68-8 tert-butyl N-(4-methoxyphenyl)carbamate 
• 100-42-5 styrene 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 104-54-1 3-Phenylpropenol 
• 645-45-4 hydrocinnamic acid chloride 
• 4119-41-9 1-iodo-3-phenylpropan 
• 2290-40-6 3-phenylpropanol triethylsilyl ether 
• 56318-53-7 3-phenylpropanoic acid triethylsilyl ester 
• 97754-31-9 N-(4-methoxyphenyl)-3-phenylpropionamide 

Relevant articles and documents

Iron-catalyzed chemoselective hydride transfer reactions

A Diaminocyclopentadienone iron tricarbonyl complex has been applied in chemoselective hydrogen transfer reductions. This bifunctional iron complex demonstrated a broad applicability in mild conditions in various reactions, such as reduction of aldehydes over ketones, reductive alkylation of various functionalized amines with functionalized aldehydes and reduction of α,β-unsaturated ketones into the corresponding saturated ketones. A broad range of functionalized substrates has been isolated in excellent yields with this practical procedure.

Hitchhiker's Guide to Reductive Amination

A comparative study of various widely used methods of reductive amination is reported. Specifically, such reducing agents as H 2, Pd/C, hydride reagents [NaBH 4, NaBH 3 CN, NaBH(OAc) 3 ], and CO/Rh 2 (OAc) 4 system were considered. For understanding the selectivity and activity of the reducing agents reviewed herein, different classes of starting materials were tested, including aliphatic and aromatic amines, as well as aliphatic and aromatic aldehydes and ketones. Most important advantages and drawbacks of the methods, such as selectivity of the target amine formation and toxicity of the reducing agents were compared. Methods were also considered from the viewpoint of green chemistry.

d-Glucose: An Efficient Reducing Agent for a Copper(II)-Mediated Arylation of Primary Amines in Water

A copper-catalyzed Ullmann-type amination with primary amines in water with a combination of copper(II) triflate [Cu(OTf)2], dipivaloylmethane, and d-glucose is reported. The mild conditions and the use of an inexpensive catalyst as well as a renewable feedstock (d-glucose and the surfactant TPGS-750-M, which is derived from vitamin E) make this protocol a safe and convenient strategy for efficient C?N bond formation. This easy-to-handle procedure is extremely competitive compared to palladium-based reactions and may be used to synthesize N-containing molecules, such as drugs or organic light-emitting diodes (OLEDs).