71291-54-8

Upstream product

• 616-45-5 2-pyrrolidinon 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 2398-37-0 3-methoxyphenyl bromide 
• 1202643-83-1 1-(3-methoxyphenyl)cyclobutan-1-ol 
• 586-38-9 3-Methoxybenzoic acid 
• 10259-22-0 ethyl 3-methoxybenzoate 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 914954-34-0 tert-butyl (4-(3-methoxyphenyl)-4-oxobutyl)carbamate 
• 161564-41-6 2-oxopyrrolidine-1-carbaldehyde diethyl acetal 
• 38102-72-6 4-oxo-4-(3-methoxyphenyl)butanenitrile 
• 628-20-6 4-Chlorobutyronitrile 

Downstream Products

• 1228556-79-3 (+)-2-(3-OMe-phenyl)-1-pyrrolidine 
• 1228556-79-3 (-)-2-(3-OMe-phenyl)-1-pyrrolidine 
• 1315512-53-8 C₁₆H₂₃NO₃ 
• 1228556-79-3 (R)-2-(m-methoxyphenyl)pyrrolidine 
• 1228556-79-3 C₁₁H₁₅NO 
• 71291-40-2 4-(3-methoxy-phenyl)-3-(2-piperidin-1-yl-propyl)-1,5,6,7-tetrahydro-azepin-2-one 
• 71291-53-7 4-(3-hydroxy-phenyl)-3-(2-piperidin-1-yl-propyl)-1,5,6,7-tetrahydro-azepin-2-one 
• 71291-41-3 4-(3-methoxy-phenyl)-3-(2-pyrrolidin-1-yl-propyl)-1,5,6,7-tetrahydro-azepin-2-one 

Relevant academic research and scientific papers

Palladium-catalyzed ortho-olefination of 2-arylpyrrolidines: A tool for increasing structural complexity in nitrogen heterocycles

The dual role of the (2-pyridyl)sulfonyl unit as directing functionality and readily removable N-protecting group has enabled an efficient and practical transformation of 2-arylpyrrolidine derivatives into more complex tricyclic frameworks via palladium-catalyzed ortho-olefination with electron deficient alkenes and subsequent cyclization upon N-deprotection under mild conditions. The key cross coupling step in the presence of N-fluoro-2,4,6-trimethylpyridinium triflate ([F+]) as the terminal oxidant is both highly efficient and tolerant to a variety of steric and electronic changes at both coupling partners. By adequate choice of reductive conditions, the N-sulfonyl deprotection can be directed to the selective formation of benzo-fused pyrrolizidine or fused pyrrolidino-benzazapine frameworks.

Synthesis of 1-Pyrroline by Denitrogenative Ring Expansion of Cyclobutyl Azides under Thermal Conditions

We herein report an efficient and systematic synthesis of 1-pyrrolines from cyclobutyl azides under thermal and neutral conditions. The reaction proceeded without any additional reagents, and nitrogen was generated as the sole by-product. Furthermore, the generated 1-pyrrolines could be continuously transformed into pyrroles, N-Boc-amines, and oxaziridines in an one-pot manner. (Figure presented.).

Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Aminobenzyloxyarylamide derivatives 1a-i and 2a-t were designed and synthesized as novel selective κ opioid receptor (KOR) antagonists. The benzoyl amide moiety of LY2456302 was changed into N-hydroxybenzamide and benzisoxazole-3(2H)-one to investigate whether it could increase the binding affinity or selectivity for KOR. All target compounds were evaluated in radioligand binding assays for opioid receptor binding affinity. These efforts led to the identification of compound 1c (κ Ki = 179.9 nM), which exhibited high affinity for KOR. Moreover, the selectivity of KOR over MOR and DOR increased nearly 2-fold and 7-fold, respectively, compared with (±)LY2456302.

Highly effective asymmetric hydrogenation of cyclic N -alkyl imines with chiral cationic Ru-MsDPEN catalysts

A range of cyclic N-alkyl imines were efficiently hydrogenated by using a chiral cationic Ru(η6-cymene)(MsDPEN)(BArF) complex (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) in high yields and up to 98% ee. A one-pot synthesis of chiral 2-phenylpyrrolidine via reductive amination was also developed.

Iridium-catalyzed enantioselective hydrogenation of cyclic imines

A catalytic complex made from [Ir(COD)Cl]2 [di-μ-chloro- bis(1,5-cyclooctadiene)diiridium(I)] precursor and (S,S)-f-Binaphane ((R,R)-1,1′-bis{(R)-4,5-dihydro-3H-dinaphtho[1,2-c:2′,1′-e] phosphepino}ferrocene) ligand effectively catalyzed the en

SUBSTITUTED N-ARYLPYRROLIDINES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

The present invention provides a compound of the formula: Formula I or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula I.

HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS

Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.