7135-33-3Relevant academic research and scientific papers
1-Benzyl-3,3-dichloro-1H-indol-2(3H)-one
Loetter,Fernandes,Van Otterlo,De Koning
, p. o157-o159 (2007)
The title compound, C15H11Cl2NO, was synthesized from N - benzyl-isatin. The compound crystallizes as stacks of mol-ecules running down the c axis. Mol-ecules within each of these stacks inter-act with each other through π-π and C - H...π inter-actions, a
Controllable synthesis of 3-chloro- and 3,3-dichloro-2-oxindoles via hypervalent iodine-mediated chlorooxidation
Jiang, Xinpeng,Yang, Liechao,Yang, Wenlong,Zhu, Yu,Fang, Liyun,Yu, Chuanming
supporting information, p. 6920 - 6924 (2019/07/22)
An efficient and controllable protocol for the synthesis of 3-chloro- and 3,3-dichloro-2-oxindoles has been developed via hypervalent iodine-promoted chlorooxidation. By using two equivalents of 1-chloro-1,2-benziodoxol-3-(1H)-one, a wide range of indoles
Synthesis of 3,3-Dihalo-2-oxindoles from 2-Substituted Indoles via Halogenation–Decarboxylation/Desulfonamidation–Oxidation Process
Jiang, Xiaojian,Zhang, Feng,Yang, Junjie,Yu, Pei,Yi, Peng,Sun, Yewei,Wang, Yuqiang
supporting information, p. 3938 - 3942 (2016/12/30)
A novel one-pot reaction which combines halogenation, decarboxylation/desulfonamidation with oxidation has been developed. Diverse valuable 3,3-dihalo-2-oxindole compounds can be produced rapidly and safely with isolated yields of up to 98% under mild conditions. (Figure presented.).
Synthesis of 3,3-dichloro-2-oxindoles from isatin-3-p-tosylhydrazones and (dichloroiodo)benzene
Hepples, Charlotte,Murphy, Graham K.
, p. 4971 - 4974 (2015/08/04)
Abstract A series of aryl- and N-substituted isatin derivatives were converted to the corresponding isatin-3-p-tosylhydrazones, and these were subjected to a Lewis base-catalyzed chlorination reaction that employs the hypervalent chlorinating agent PhICl2. The discovery of p-tosylhydrazones as chlorination precursors has expanded the functional group tolerance of the chlorination reaction to now include carbamates, acetamides, and sulfonates. Additionally, this allowed us to circumvent the use of the diazo group in our chlorination reaction, and offers a new avenue for exploring our two-step deoxygenative dihalogenation reaction. We also disclose the use of PhICl2 for the oxidative chlorination of sulfinates to the corresponding sulfonyl chlorides.
Synthesis of the dibenzopyrrocoline alkaloid skeleton: indolo[2,1-a]isoquinolines and related analogues
L?tter, Angelique N.C.,Pathak, Rakhi,Sello, Thato S.,Fernandes, Manuel A.,van?Otterlo, Willem A.L.,de Koning, Charles B.
, p. 2263 - 2274 (2007/10/03)
The indolo[2,1-a]isoquinoline and pyrrolo[2,1-a]isoquinoline nuclei have been synthesized from N-benzylindole or ethyl 1H-indol-1-ylacetate and N-benzylpyrrole precursors, respectively. Firstly, at C-2 of either the indole or pyrrole nucleus, aromatic rin
