7145-28-0

Basic information

• Product Name: 2-METHOXYNICOTINAMIDE
• Synonyms: 2-METHOXYNICOTINAMIDE;Nsc74202;2-Methoxypyridine-3-carboxamide
• CAS NO: 7145-28-0
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15062
• Mol File: 7145-28-0.mol

Chemical Properties

• Boiling Point: 295 °C at 760 mmHg
• Flash Point: 132.2 °C
• Appearance: /
• Density: 1.213 g/cm³
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 2-METHOXYNICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYNICOTINAMIDE(7145-28-0)
• EPA Substance Registry System: 2-METHOXYNICOTINAMIDE(7145-28-0)

Safety Data

• Hazardous Substances Data: 7145-28-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxynicotinamide is used as a therapeutic agent for its potential role in treating various diseases, such as diabetes and neurodegenerative disorders. Its protective properties against oxidative stress and inflammation contribute to its potential as a treatment option.
Used in Biotechnology Industry:
2-Methoxynicotinamide is used as a research compound for exploring its potential applications in medicine and biotechnology. Ongoing studies aim to understand its mechanisms of action and identify new therapeutic targets for various conditions.

InChI:InChI=1/C7H8N2O2/c1-11-7-5(6(8)10)3-2-4-9-7/h2-4H,1H3,(H2,8,10)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 7254-34-4 2-methoxy-3-cyanopyridine 
• 67-56-1 methanol 
• 98-92-0 nicotinamide 
• 53750-65-5 2-methoxypyridine-3-carbonyl chloride 
• 16498-81-0 2-methoxynicotinic acid 

Downstream Products

• 20265-38-7 3-amino-2-methoxypyridine 

Relevant articles and documents

PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6

Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.

A pyridine amide synthetic method of compound

The invention discloses a method for synthesizing a pyridine-amide compound. The method comprises the steps of carrying out hydrolysis on a pyridine cyanogen compound shown by a formula II as a starting material in water as a solvent in the presence of an ETS-10 molecular sieve as a catalyst, heating to 100-150 DEG C, reacting until the reaction, which is tracked and detected by virtue of TLC (Thin-Layer Chromatography), is completed and carrying out post-treatment on the reaction solution to obtain the pyridine-amide compound represented by the formula I. According to the method disclosed by the invention, the ETS-10 molecular sieve is taken as a catalyst to carry out hydrolysis on pyridine cyanogen to obtain a single pyridine-amide product, the conversion rate is 100%, the yield is above 95% and the catalyst can be repeatedly used for at least 5 times.

8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are 8-substituted quinolines and related analogues as sirtuin-modulating compounds of Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Photochemical Alkylation, Hydroxyalkylation, and Alkoxylation of Pyridinecarboxamides in Alcohol

The UV-irradiation of 2- and 4-pyridinecarboxamides in alcohol brings about alkylation and/or hydroxyalkylation in the pyridine ring.In the irradiation of 3-pyridinecarboxamide in the presence of sulfuric acid, ionic reaction (alkoxylation at the 2- and 6-position) and radical reaction (alkylation at the 4- and 6-position) occur in parallel.The effects of quenchers indicate that two alkylation products originate from one excited triplet state which is quenched by energy-transfer mechanism and that two alkoxylation products originate from the excited singlet state.

SIMULTANEOUS PARTICIPATION OF SEVERAL EXCITED STATES IN PHOTOCHEMICAL METHOXYLATION AND METHYLATION OF 3-PYRIDINECARBOXAMIDE IN METHANOL

The UV-irradiation of 3-pyridinecarboxamide in methanol in the presence of sulfuric acid brings about methoxylation (ionic reaction) at the 2- and 6-position and methylation (radical reaction) at the 4- and 6-position.The effects of quenchers indicate that two methylation products originate from one excited triplet state which is quenched by energy transfer mechanism and that two methoxylation products originate from two different excited singlet states which are quenched by electron transfer mechanism.