714972-01-7

Upstream product

• 2839-49-8 2-fluoro-9H-xanthen-9-one 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 5570-19-4 2-nitrophenylboronic acid 
• 930-68-7 cyclohexenone 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 

Downstream Products

• 2839-49-8 2-fluoro-9H-xanthen-9-one 

Relevant academic research and scientific papers

Electrochemically Mediated Direct C(sp3)?H Sulfonylation of Xanthene Derivatives

The construction of C(sp3)-sulfonyl bonds through direct sulfonylation of C(sp3)?H bond presents a number of challenges, so an electrochemical oxidation-induced direct sulfonylation of the xanthene C(sp3)?H bond was developed. Significant advantages of this method are high atom efficiency, functional group tolerance, transition metal- and oxidant-free conditions. The in vitro cytotoxicity of all product is evaluated by MTT assay against human cancer cell lines. The results reveal that most of the compounds 3 da and 3 af have good inhibitory activity on tumor cell lines. (Figure presented.).

A radical-radical cross-coupling reaction of xanthene with sulfonyl hydrazides: Facile access to xanthen-9-sulfone derivatives

A straightforward strategy for direct incorporation of sulfonyl units into a xanthene moiety for accessing xanthen-9-sulfone derivatives in good to excellent yields has been established via metal-free radical-radical cross-coupling reaction of xanthenes and sulfonyl hydrazides. Using easily accessible starting materials, this methodology proceeds efficiently with a high degree of functional group compatibility and with a wide scope of both xanthenes and sulfonyl hydrazides under operationally simple reaction conditions. Mechanistic investigations revealed that sulfonyl radicals could be generated from sulfonyl hydrazides in the presence of TBHP under an oxygen atmosphere.

Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums

Oxygenation of cyclic diphenyl iodoniums (CDPIs) with varied medium-ring sizes has been fully investigated. This practical copper-catalyzed tandem reaction of CDPIs with water as the oxygen source enables the construction of derivatised dibenzofurans and xanthenes at moderate to good yields. Moreover, structurally important xanthones are also successfully accessed under the oxygenation conditions with additional TEMPO.

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Small molecule mGluR1 enhancers, which are 9H-xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides, have been previously reported. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides with improved pharmacokinetic proper

Oxazoles as mGluR 1 enhancers

The invention relates to carboxamide derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as mGluR1 enhancers in the treatment and prevention of neurological disorders and diseases, such as Alzheimer's disease and dementia.