71657-86-8

Upstream product

• 62624-44-6 (3R,4S)-ethyl 2-oxo-4-phenyl-1-tosylpyrrolidine-3-carboxylate 
• 5292-53-5 diethyl benzalmalonate 
• 185067-05-4 ethyl 2-carbethoxy-3-cyano-3-phenylpropionate 
• 52450-32-5 Ethyl (E)-2-oxo-4-phenylpyrrolidine-3-carboxylate 

Downstream Products

• 62624-45-7 (S)-4-phenyl-1-tosylpyrrolidin-2-one 
• 128372-78-1 (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone 
• 128372-78-1 (-)-(S)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 62624-46-8 (S)-(+)-3-phenylpyrrolidine 
• 61586-46-7 (-)-(R)-3-Phenylpyrrolidine 
• 138812-85-8 (3S,4S)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 
• 138782-42-0 (3R,4R)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 

Relevant academic research and scientific papers

Lewis acid catalyzed highly stereoselective domino-ring-opening cyclization of activated aziridines with enolates: Synthesis of functionalized chiral γ-lactams

Figure presented. A highly enantio- and diastereoselective Lewis acid catalyzed SN2-type ring opening followed by cyclization of aziridines with active methylene carbon nucleophiles to functionalized chiral γ-lactams in a domino fashion has been developed. γ-Lactams have been desulfonated and decarboxylated, providing pyrrolidone-3-carboxylate and N-tosylpyrrolidinone derivatives, respectively, in good yields.

Resolution of 4-phenyl-2-pyrrolidinone: A versatile synthetic intermediate

A resolution of 4-phenyl-2-pyrrolidinone is described. The resulting enantiomerically pure pyrrolidinones are exploited as precursor to 3-phenylpyrrolidines and 3-phenyl-γ-amino acids (4-amino-3-phenylbutanoic acid derivatives).