719-41-5

Usage

InChI:InChI=1/C13H8O3/c14-9-5-3-7-11-12(9)13(15)8-4-1-2-6-10(8)16-11/h1-7,14H

Upstream product

• 118-55-8 phenyl Salicylate 
• 108-46-3 recorcinol 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 108-24-7 acetic anhydride 
• 69-72-7 salicylic acid 
• 2944-57-2 resorcinol disalicylate 
• 7446-70-0 aluminium trichloride 
• 103569-37-5 1-[2]naphthoyloxy-xanthen-9-one 
• 98-95-3 nitrobenzene 
• 123-31-9 hydroquinone 
• 17607-01-1 1-nitroxanthone 
• 62-53-3 aniline 
• 6312-86-3 NSC 40575 

Downstream Products

• 69-72-7 salicylic acid 
• 108-46-3 recorcinol 
• 102001-83-2 9-(2-methoxy-phenyl)-xanthene-1,9-diol 
• 94966-35-5 1-(2-oxo-2-phenyl-ethoxy)-xanthen-9-one 
• 103049-21-4 2-benzoyl-1-benzoyloxy-xanthen-9-one 
• 102184-24-7 1-hydroxy-2-(4-nitro-benzoyl)-xanthen-9-one 
• 102661-85-8 2-acetyl-1-benzoyloxy-xanthen-9-one 
• 101880-55-1 2-benzenesulfonyl-1-hydroxy-xanthen-9-one 
• 51792-18-8 2,7-dinitro-xanthen-9-one 
• 335434-57-6 2,2-diphenyl-2H-12H-pyrano[2,3-a]xanthene 
• 17623-99-3 1,4-Dihydroxy-xanthon 
• 92-83-1 xanthene 
• 6563-60-6 methoxy-9H-xanthen-9-one 
• 92964-91-5 1-Allyloxy-xanthon 

Relevant academic research and scientific papers

Nanoporous metal oxides with tunable and nanocrystalline frameworks via conversion of metal-organic frameworks

Nanoporous metal oxide materials are ubiquitous in the material sciences because of their numerous potential applications in various areas, including adsorption, catalysis, energy conversion and storage, optoelectronics, and drug delivery. While synthetic

Synthesis, SAR and biological evaluation of natural and non-natural hydroxylated and prenylated xanthones as antitumor agents

In order to explore the detailed structure-activity relationship (SAR) around xanthone scaffold bearing hydroxyl and prenyl moieties, twenty-nine natural and non-natural hydroxylated and prenylated xanthones have been synthesized and evaluated for their in vitro anti-proliferative activities against five human cancer cell lines, including HepG2 (hepatocelluar carcinoma), HCT-116 (colon carcinoma), A549 (lung carcinoma), BGC823 (gastric carcinoma) and MDAMB- 231 (breast carcinoma). The SAR analysis revealed that the anti-proliferative activity of the xanthones is substantially influenced by the position and number of attached hydroxyl and prenyl groups, and the presence of hydroxyl group ortho to the carbonyl function of xanthone scaffold contributes significantly to their cytotoxicity. The new prenylated xanthone 20 with a relatively simple structure, namely 1,3,8-trihydroxy-2-prenylxanthone, was found to exhibit potent antitumor activities comparable to mangostin against all the five cancer cell lines. Further mechanistic studies suggested that compound 20 induces apoptosis and causes cell cycle arrest at S phase in HepG2 cells. These results have highlighted compound 20 as a new potential lead candidate for future development of novel potent broad-spectrum antitumor agents.

Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines

In a study involving the synthesis of bis-intercalators, a bisxanthone and a minor product, 1-(6-bromohexyloxy)-xanthone were obtained. Although no capacity to inhibit the growth of human tumor cell lines was observed for the bisxanthone, the bromoalkoxyx

Aromatic Nitro group Displacement Reactions. Part 2. The Synthesis of Diarylamines and some Heteroaromatic Analogues.

In dipolar aprotic solvents, activated aromatic nitro-groups can usually be displaced by anilines of enhanced N-acidity in the presence of the heavier alkali-metal carbonates.When catalysed by potassium t-butoxide, however, attack occurs preferentially at other reactive centers in the molecule, except where the nitro-group is highly activated.Some of the resulting diarylamines (the term is here expanded to include arylaminoxanthen-9-ones) are intermediates in the synthesis of heterocycles.

An Abnormal Thermal Condensation of Hydroquinone with Ethyl Salicylate

Thermal condensation of hydroquinone with ethyl salicylate in refluxing diphenyl ether affords 1-hydroxyxanthone (I), 1,4-disalicyloxyhydroquinone (IIa), 4'-hyroxyphenyl salicylate (III), 1-hydroxy-4-salicyloxyxanthone (IVa), 1,4-dihydroxyxanthone (V) and 2-hydroxyxanthone (VI).The structures of these comnpounds have been confirmed by PMR and mass spectral data.

Thermal Conversion of Salol into Xanthone: A Mechanistic Study

The thermal conversion of salol (1) into xanthone has been rationalized as proceeding via the keto-ketene intermediate (7) which is trapped by phenols (9, 12 and 15).

Studies in Synthesis of Xanthone Derivatives: Part III+ - A New One-step Synthesis of Xanthones

Ethyl salicylate condenses with different phenols in refluxing diphenyl ether to give various xanthones in good yields.In the case of resorcinol, hydroquinone, catechol and 3,4-xylenol corresponding phenyl salicylate derivatives are also obtained.Condensation with hydroxycoumarins affords pyranoxanthones, which can not be prepared by the Pechmann condensation of hydroxyxanthones.The structures of the intermediates and final products are established by spectral data (IR, PMR and 13C NMR).