Welcome to LookChem.com Sign In|Join Free
  • or

71963-77-4

Post Buying Request

71963-77-4 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Artemether Manufacturer/High quality/Best price/In stock
Cas No: 71963-77-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Artemether with high quality cas:71963-77-4
Cas No: 71963-77-4
USD $ 300.0-400.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Artemether supplier in China
Cas No: 71963-77-4
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
Artemether71963-77-4 in bulk supply
Cas No: 71963-77-4
USD $ 500.0-500.0 / Kilogram 1 Kilogram 5000 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Artemether
Cas No: 71963-77-4
No Data No Data Metric Ton/Day Hubei Vanz Pharm Co.,Ltd Contact Supplier
Artemether CAS:71963-77-4 Safe delivery Free of customs clearance
Cas No: 71963-77-4
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Artemether in bulk supply CAS NO.71963-77-4
Cas No: 71963-77-4
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Artemether 71963-77-4
Cas No: 71963-77-4
No Data 1 Kilogram 10 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
Factory supply high quality Artemether,71963-77-4
Cas No: 71963-77-4
No Data No Data Metric Ton/Day Hubei Taiho Chemical Co.,LTD Contact Supplier
Artemether
Cas No: 71963-77-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier

71963-77-4 Usage

Chemical Properties

White Solid

Definition

ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.

Uses

Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when

Uses

Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.

Uses

atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist
InChI:InChI=1/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16?/m1/s1

71963-77-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (A9361)  Artemether  ≥98% (HPLC) 71963-77-4 A9361-25MG 3,001.05CNY Detail
Sigma (A9361)  Artemether  ≥98% (HPLC) 71963-77-4 A9361-5MG 745.29CNY Detail
USP (1042780)  Artemether  United States Pharmacopeia (USP) Reference Standard 71963-77-4 1042780-100MG 4,647.24CNY Detail
TCI America (A2190)  Artemether  >98.0%(HPLC) 71963-77-4 25g 1,850.00CNY Detail
TCI America (A2190)  Artemether  >98.0%(HPLC) 71963-77-4 5g 620.00CNY Detail

71963-77-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name artemether

1.2 Other means of identification

Product number -
Other names Gvither

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71963-77-4 SDS

71963-77-4Synthetic route

Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

dihydroartemisinin
71939-50-9

dihydroartemisinin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With perchloric acid In ethanol at 0℃; for 8h; pH=2; Reagent/catalyst; pH-value; Temperature;97.6%
trimethoxypropane
24823-81-2

trimethoxypropane

dihydroartemisinin
71939-50-9

dihydroartemisinin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With sulfuric acid In isopropyl alcohol at 0 - 12℃; for 4h; pH=2; Solvent; Temperature; Reagent/catalyst; pH-value;97.2%
dihydroartemisinin
71939-50-9

dihydroartemisinin

trimethyl orthoformate
149-73-5

trimethyl orthoformate

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With methanesulfonic acid In ethanol at 5 - 20℃; for 3h; pH=5; Solvent; pH-value; Temperature; Reagent/catalyst;96.6%
toluene-4-sulfonic acid In methanol at 30℃; for 0.5h;
methanol
67-56-1

methanol

dihydroartesiminin
81496-81-3

dihydroartesiminin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With dimethylphosphoric acid; boron trifluoride diethyl etherate at 3 - 20℃; Reagent/catalyst; Temperature;96.2%
dihydroartesiminin
81496-81-3

dihydroartesiminin

trimethyl orthoformate
149-73-5

trimethyl orthoformate

artemether
71963-77-4

artemether

Conditions
ConditionsYield
Stage #1: dihydroartesiminin; trimethyl orthoformate In methanol at 20℃; for 0.25h;
Stage #2: With acetyl chloride In methanol at 10 - 15℃;
Stage #3: With sodium hydrogencarbonate In methanol; water at 0 - 5℃; for 2h; Product distribution / selectivity;
74.67%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

dihydroartemisinin
71939-50-9

dihydroartemisinin

A

9,10-dehydrodihydroartemisinin
82596-30-3

9,10-dehydrodihydroartemisinin

B

artemether
71963-77-4

artemether

C

C20H32O7
120020-67-9

C20H32O7

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In diethyl ether for 24h; Ambient temperature;A n/a
B n/a
C 70%
(S)-3-hydroxybutyric acid methyl ester
53562-86-0

(S)-3-hydroxybutyric acid methyl ester

dihydroartemisinin
71939-50-9

dihydroartemisinin

A

9,10-dehydrodihydroartemisinin
82596-30-3

9,10-dehydrodihydroartemisinin

B

artemether
71963-77-4

artemether

C

C20H32O7
119946-74-6

C20H32O7

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In diethyl ether for 24h; Ambient temperature;A n/a
B n/a
C 56%
methanol
67-56-1

methanol

dihydroartemisinin
71939-50-9

dihydroartemisinin

A

artemether
71963-77-4

artemether

B

α-artemether

α-artemether

Conditions
ConditionsYield
In benzene at 20℃; for 24h; Product distribution; Further Variations:; Reaction partners; Solvents; reaction times;
With hydrogenchloride In acetic acid methyl ester; water at 20 - 23℃; for 4.5h; Temperature; Concentration; Solvent;
2-Methoxypropene
116-11-0

2-Methoxypropene

dihydroartesiminin
81496-81-3

dihydroartesiminin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
Stage #1: 2-Methoxypropene; dihydroartesiminin In methanol at 20℃; for 0.25h;
Stage #2: With methanesulfonyl chloride In methanol at 10 - 20℃;
Stage #3: With sodium hydrogencarbonate In methanol at 20℃; for 2h; Product distribution / selectivity;
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

dihydroartesiminin
81496-81-3

dihydroartesiminin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
Stage #1: 2,2-dimethoxy-propane; dihydroartesiminin In methanol at 20℃; for 0.25h;
Stage #2: With chloro-trimethyl-silane In methanol at 10 - 20℃;
Stage #3: With sodium hydrogencarbonate In methanol at 20℃; for 2h; Product distribution / selectivity;
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

dihydroartesiminin
81496-81-3

dihydroartesiminin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
Stage #1: Trimethyl orthoacetate; dihydroartesiminin With sulfuric acid In methanol
Stage #2: With sulfuric acid In methanol
Stage #3: With sodium hydrogencarbonate In methanol; water Product distribution / selectivity;
With boron trifluoride diethyl etherate In methanol at 10 - 20℃; for 4h;98 g
α-artemether

α-artemether

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With chloro-trimethyl-silane In toluene at 25 - 30℃; for 12h;
methanol
67-56-1

methanol

dihydroartesiminin
81496-81-3

dihydroartesiminin

A

artemether
71963-77-4

artemether

B

α-artemether

α-artemether

Conditions
ConditionsYield
Stage #1: dihydroartesiminin With dodecatungstophosphoric acid hydrate In dichloromethane at 20℃; for 0.0833333h;
Stage #2: methanol In dichloromethane at 20℃; for 3h; optical yield given as %de;
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

A

artemether
71963-77-4

artemether

B

α-artemether

α-artemether

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / methanol
2.1: dodecatungstophosphoric acid hydrate / dichloromethane / 0.08 h / 20 °C
2.2: 3 h / 20 °C
View Scheme
methanol
67-56-1

methanol

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

A

artemether
71963-77-4

artemether

B

α-artemether

α-artemether

Conditions
ConditionsYield
With sodium tetrahydroborate; cellulose sulfuric acid; trimethyl orthoformate In tetrahydrofuran at -5 - 20℃; for 2.5h;A n/a
B n/a
methanol
67-56-1

methanol

dihydroartemisinin
71939-50-9

dihydroartemisinin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With amberlyst-15 In 2-methyltetrahydrofuran at 20℃; for 4h; Kinetics; Reagent/catalyst; Temperature; Flow reactor;
methanol
67-56-1

methanol

dihydroartemisinin
71939-50-9

dihydroartemisinin

artemether
71963-77-4

artemether

Conditions
ConditionsYield
With perchloric acid In dichloromethane at 30 - 38℃; for 0.166667h; Temperature; Large scale;756 g
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

artemether
71963-77-4

artemether

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With methanol; sodium tetrahydroborate at -10 - -5℃; for 3h;
Stage #2: Trimethyl orthoacetate With sulfuric acid; boron trifluoride diethyl etherate In methanol at 20℃; for 4h; pH=6 - 8; Catalytic behavior; Temperature;
101.9 g
artemether
71963-77-4

artemether

deoxy-β-artemether

deoxy-β-artemether

Conditions
ConditionsYield
With zinc In acetic acid for 1h; Ambient temperature;72%
artemether
71963-77-4

artemether

A

9α-acetoxy-10β-methoxyartemethin-I

9α-acetoxy-10β-methoxyartemethin-I

B

3α-hydroxydeoxydihydroqinghaosu

3α-hydroxydeoxydihydroqinghaosu

C

3α-hydroxy-12β-methoxyartemethin-III

3α-hydroxy-12β-methoxyartemethin-III

Conditions
ConditionsYield
With iron(II) sulfate In water; acetonitrile at 37℃;A 37%
B 4%
C 44%
DL-cysteine hydrochloride
10318-18-0

DL-cysteine hydrochloride

artemether
71963-77-4

artemether

A

9α-acetoxy-10β-methoxyartemethin-I

9α-acetoxy-10β-methoxyartemethin-I

B

3α-hydroxy-12β-methoxyartemethin-III

3α-hydroxy-12β-methoxyartemethin-III

C

Acetic acid (1R,3S,4R,4aS,7R,8S,8aR)-8-ethyl-8a-hydroxy-3-methoxy-4,7-dimethyl-octahydro-isochromen-1-yl ester

Acetic acid (1R,3S,4R,4aS,7R,8S,8aR)-8-ethyl-8a-hydroxy-3-methoxy-4,7-dimethyl-octahydro-isochromen-1-yl ester

D

3-[2-((1R,3S,4R,4aS,7R,8S,8aR)-1-Acetoxy-8a-hydroxy-3-methoxy-4,7-dimethyl-octahydro-isochromen-8-yl)-ethylsulfanyl]-2-amino-propionic acid

3-[2-((1R,3S,4R,4aS,7R,8S,8aR)-1-Acetoxy-8a-hydroxy-3-methoxy-4,7-dimethyl-octahydro-isochromen-8-yl)-ethylsulfanyl]-2-amino-propionic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate; iron(II) sulfate In acetonitrile at 20℃; for 4h; Further byproducts given;A 26%
B 44%
C 10%
D 3.2%
artemether
71963-77-4

artemether

1,4-diacetylbenzene bis(trimethylsilyl) enol ether

1,4-diacetylbenzene bis(trimethylsilyl) enol ether

10-m-acetylphenylartemisinin dimer

10-m-acetylphenylartemisinin dimer

Conditions
ConditionsYield
Stage #1: artemether With titanium tetrachloride In dichloromethane at -78℃; for 0.0833333h; Metallation;
Stage #2: 1,4-diacetylbenzene bis(trimethylsilyl) enol ether In dichloromethane at -78℃; for 1h; Condensation;
33%
artemether
71963-77-4

artemether

A

3α-hydroxydeoxy-β-artemether

3α-hydroxydeoxy-β-artemether

B

2-[(R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde

2-[(R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde

C

9α-acetoxy-10β-methoxyartemethin-I

9α-acetoxy-10β-methoxyartemethin-I

Conditions
ConditionsYield
With iron(II) chloride In acetonitrile for 0.0333333h; Ambient temperature;A 23%
B 16%
C 32%
artemether
71963-77-4

artemether

1,4-diacetylbenzene bis(trimethylsilyl) enol ether
183060-22-2

1,4-diacetylbenzene bis(trimethylsilyl) enol ether

10-p-acetylphenylartemisinin dimer
229981-82-2

10-p-acetylphenylartemisinin dimer

Conditions
ConditionsYield
Stage #1: artemether With titanium tetrachloride In dichloromethane at -78℃; for 0.0833333h; Metallation;
Stage #2: 1,4-diacetylbenzene bis(trimethylsilyl) enol ether In dichloromethane at -78℃; for 1h; Condensation;
26%
DL-cysteine hydrochloride
10318-18-0

DL-cysteine hydrochloride

artemether
71963-77-4

artemether

C18H29NO6S

C18H29NO6S

Conditions
ConditionsYield
With sodium hydrogencarbonate; iron(II) sulfate In acetonitrile at 20℃; for 4h;1.4%
Mn(TPP)Cl
32195-55-4

Mn(TPP)Cl

artemether
71963-77-4

artemether

Acetic acid (1R,3S,4R,4aS,7R,8S,8aR)-8a-hydroxy-3-methoxy-4,7-dimethyl-8-[2-((4Z,10Z,15Z,19Z)-(S)-5,10,15,20-tetraphenyl-2,3,22,24-tetrahydro-porphin-2-yl)-ethyl]-octahydro-isochromen-1-yl ester

Acetic acid (1R,3S,4R,4aS,7R,8S,8aR)-8a-hydroxy-3-methoxy-4,7-dimethyl-8-[2-((4Z,10Z,15Z,19Z)-(S)-5,10,15,20-tetraphenyl-2,3,22,24-tetrahydro-porphin-2-yl)-ethyl]-octahydro-isochromen-1-yl ester

Conditions
ConditionsYield
With tetra(n-butyl)ammonium borohydride; cadmium(II) nitrate 1.) CH2Cl2, r.t., 1 h, 2.) CH2Cl2, DMF, 30 min; Yield given. Multistep reaction;
artemether
71963-77-4

artemether

A

β-2-deoxy-9-epidihydroartemisinin
1356857-18-5

β-2-deoxy-9-epidihydroartemisinin

B

(2S, 3R, 6S)-2-(3-oxobutyl)-3-methyl-6-<(R)2-propanal>-cyclohexanone
107466-88-6

(2S, 3R, 6S)-2-(3-oxobutyl)-3-methyl-6-<(R)2-propanal>-cyclohexanone

C

deoxydihydroqinghaosu
72807-92-2

deoxydihydroqinghaosu

Conditions
ConditionsYield
With 1-Benzyl-1,4-dihydronicotinamide; lumiflavin In acetonitrile at 20℃; for 2.5h; pH=7.4; aq. phosphate buffer; Inert atmosphere;
artemether
71963-77-4

artemether

A

β-2-deoxy-9-epidihydroartemisinin
1356857-18-5

β-2-deoxy-9-epidihydroartemisinin

B

deoxydihydroqinghaosu
72807-92-2

deoxydihydroqinghaosu

Conditions
ConditionsYield
With 1-Benzyl-1,4-dihydronicotinamide; riboflavin In acetonitrile at 20℃; for 3h; pH=7.4; aq. phosphate buffer; Inert atmosphere;A 52 %Spectr.
B 12 %Spectr.
artemether
71963-77-4

artemether

A

9α-acetoxy-10β-methoxyartemethin-I

9α-acetoxy-10β-methoxyartemethin-I

B

3α-hydroxy-12β-methoxyartemethin-III

3α-hydroxy-12β-methoxyartemethin-III

Conditions
ConditionsYield
With oxygen; methylene blue; ascorbic acid In acetonitrile at 20℃; for 24h; pH=7.4; aq. phosphate buffer;

71963-77-4Downstream Products

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields