71963-77-4Relevant articles and documents
One-pot green synthesis of β-artemether/arteether
Kumar, Atul,Bishnoi, Ajay Kumar
, p. 31973 - 31976 (2014)
An efficient one pot green synthesis of β-artemether/arteether from artemisinin has been developed using a sodium borohydride-cellulose sulfuric acid (CellSA) catalyst system. The green methodology is high yielding and the catalyst has good recyclability.
A process for preparing β - pedic ether process
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Paragraph 0023-0024; 0025-0026; 0027-0028, (2018/04/21)
The invention discloses a technology for preparing beta-artemether. The technology comprises the following steps: reducing an initial raw material artemisinin in the presence of a reducing agent to generate dihydroartemisinin, and carrying out an etherification reaction on dihydroartemisinin and trimethyl orthoacetate in the presence of a catalyst to prepare beta-artemether. Experiments prove that the technology allows the content of alpha-artemether generated in the methyl etherification reaction to be smaller than 3%, the HPLC purity of the obtained beta-artemether to be improved to above 99.8%, the content of single impurities to be smaller than 0.1% respectively and the quality of the above product to accord with requirements of United States Pharmacopeia; and the total mole yield of the product by artemisinin can reach 95% or above. The technology can avoid tedious intermediate processing links in the prior art, realizes simple-operation low-cost high-yield preparation of highly pure beta-artemether, accords with industrial production demands of beta-artemether, and has industrial application values.
Process for preparation of β - pedic methyl ether
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Paragraph 0041-0044; 0067; 0068, (2017/08/25)
The invention relates to a preparation method of beta-artemether. The preparation method comprises the following steps of: (1) adding a solvent alcohol to dihydroartemisinin to dissolve dihydroartemisinin; (2) reducing the temperature of a solution obtained from the step (1) to 0-5 DEG C, and adding an etherealization reagent; (3) dropping the alcoholic solution of an acid at 0-20 DEG C to a system obtained from the step (2), and reacting at 0-30 DEG C, wherein the pH value of a reaction system is 1-3; (4) separating out solids from the system by adding water to the reaction liquid of the step (3), filtering, and washing the obtained solids by using water to obtain a compound; (5) drying the compound obtained from the step (4) to constant weight at 35-45 DEG C to obtain beta-artemether, wherein the purity of beta-artemether is more than 99%. The preparation method disclosed by the invention effectively inhibits the generation of isomer alpha-artemether in reaction, can enable the etherealization reaction to be mildly carried out and is simple in post-treatment and high in product purity. According to the invention, the purity of all prepared beta-artemether crude products is higher than 99%.