72037-57-1

Basic information

• Product Name: (E)-2-benzylidene-1,1-dimethylhydrazine
• Synonyms: (E)-2-benzylidene-1,1-dimethylhydrazine
• CAS NO: 72037-57-1
• Molecular Weight: 148.208
• Mol File: 72037-57-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-2-benzylidene-1,1-dimethylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-benzylidene-1,1-dimethylhydrazine(72037-57-1)
• EPA Substance Registry System: (E)-2-benzylidene-1,1-dimethylhydrazine(72037-57-1)

Safety Data

• Hazardous Substances Data: 72037-57-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 57-14-7 N,N-Dimethylhydrazine 

Downstream Products

• 114701-62-1 ethyl 2,2-difluoro-3-oxo-3-phenylpropanoate 
• 154709-19-0 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile 
• 256934-08-4 N-dimethylamino-2-phenyl-3-methoxy-2,5-dihydropyrrole 
• 78817-44-4 acetic acid N-benzyl-N',N'-dimethyl-hydrazide 
• 78817-45-5 benzoic acid N-benzyl-N',N'-dimethyl-hydrazide 
• 561007-12-3 4,4,4-trifluoro-2-hydroxy-2-phenylbutyronitrile 
• 709-21-7 3,3,3-trifluoro-1-phenylpropan-1-one 
• 561007-11-2 methyl-(3,3,3-trifluoro-1-phenylpropenyl)-diazene 

Relevant articles and documents

Improved efficient conversion of aldehydes to nitriles via their N,N- dimethyl hydrazones

Aldehyde N,N-dimethylhydrazones undergoes facile oxidative cleavage to nitriles on reaction with DMS and K2CO3 in quantitative yields. Nitriles can also be easily obtained in high yields in a 'one-pot' process starting from the corresponding aldehydes.

Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants

Themisone, also known as Atrolactamide, was found, in the 1950s, to be a very potent anticonvulsant. It was hypothesized that the -CF3 substitution would maintain the anticonvulsant activity. Anticonvulsant testing of our novel compounds by the

Reaction of the lithio-derivative of methoxyallene with hydrazones. Part 1: Synthesis and transformation of α-allenyl hydrazines

The lithio-derivative of methoxyallene reacts with aldehyde hydrazones leading to expected α-allenyl hydrazines when ether is the solvent of the reaction. The yields are good as well as the diastereoselectivity observed in the case of SAMP-hydrazones. These hydrazines are cleanly transformed to N-dialkylamino-3-methoxy-3-pyrrolines when they are reacted with n-BuLi in THF. These compounds are sometimes accompanied by the isomeric 4-methyl azetidines. The N-dialkylamino-3-methoxy-3-pyrrolines are transformed to 3-methoxy-3-pyrrolines by hydrogenolysis of the nitrogen-nitrogen bond, to 3-alkoxy-pyrroles by treatment with a peracid and to 3-amino-pyrroles by acidic migration of the dialkylamino group. In the case of SAMP-hydrazines, the obtained 3-methoxy-3-pyrrolines have a high enantiomeric purity. Lastly, attempts to prepare α-hydrazino-esters (and subsequently α-amino-esters) by ozonolysis of the allenyl moiety failed due to the formation of a methyl glyoxylate.