7204-35-5Relevant academic research and scientific papers
Convenient synthesis of 2-Amino-4H-chromenes from photochemically generated o-quinone methides and malononitrile
Fujiwara, Makoto,Sakamoto, Masanori,Komeyama, Kimihiro,Yoshida, Hiroto,Takaki, Ken
, p. 59 - 66 (2015/01/30)
2-Amino-4H-chromenes were synthesized in moderate to good yields by the reaction of o-quinone methides photochemically generated from o-(dimethylaminomethyl)phenols with malononitrile. This method was applicable to the synthesis of fluorinated chromenes that were difficult to obtain by other methods. In addition, o-(hydroxymethyl)phenols could be used for the reaction in the presence of tertiary amine bases.
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
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Page 80, (2008/06/13)
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
2-(2-Amino-2-methylpropyl)phenols by C-C-Linkage of 2-Hydroxybenzyl Alcohols with 2-Nitropropane Anions
Diery, Helmut,Renger, Bernd
, p. 1239 - 1251 (2007/10/02)
The 2-hydroxybenzyl alcohols 1, 6, 8a, and 8e can be converted into the 2-(2-methyl-2-nitropropyl)-phenols 2, 7, and 9 by a SRN1-reaction with the sodium salt of 2-nitropropane.Catalytic hydrogenation yields the amines 3 and 10.The consequent reactions - leading to the quaternary salts 13 and 14 and as to the addition-compounds 15 and 16 - are negatively influenced by the strong steric shielding of the amino groups.
