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Usage

Uses

Used in Pharmaceutical Industry:
Alpha2-Piperidino-2,4-xylenol is used as an active ingredient in pharmaceutical formulations for its antimicrobial properties, contributing to the prevention and treatment of various infections.
Used in Personal Care Products:
In the personal care industry, alpha2-Piperidino-2,4-xylenol is used as a preservative and antimicrobial agent in products such as cosmetics, lotions, and creams to ensure their safety and efficacy by preventing microbial contamination.
Used in Industrial Cleaning Agents:
Alpha2-Piperidino-2,4-xylenol is utilized in the formulation of industrial cleaning agents to provide effective disinfection and sanitization, ensuring a clean and hygienic environment in various settings.
Used in Medical and Healthcare Settings:
In medical and healthcare settings, alpha2-Piperidino-2,4-xylenol is used as a topical antiseptic for skin disinfection, helping to prevent infections and promote healing. It is also employed in the treatment of various skin infections due to its ability to kill and inhibit the growth of bacteria and other microorganisms.
However, it is crucial to handle alpha2-Piperidino-2,4-xylenol with care, as it can be toxic and hazardous if not used properly. Proper safety measures and guidelines should be followed to minimize potential risks associated with its use.

Upstream product

• 110-89-4 piperidine 
• 67-56-1 methanol 
• 106-44-5 p-cresol 
• 75-09-2 dichloromethane 
• 569646-48-6 [2-(tert-butyl-diphenyl-silanyloxy)-5-methyl-benzyl]-dimethyl-amine 
• 7204-35-5 2-(dimethylamino-methyl)-4-methyl-phenol 
• 50-00-0 formaldehyd 

Downstream Products

• 75445-46-4 2-(2-Amino-2-methylpropyl)-4-methylphenol 
• 75445-40-8 4-Methyl-2-(2-methyl-2-nitropropyl)phenol 

Relevant academic research and scientific papers

Manganese-Catalyzed Aminomethylation of Aromatic Compounds with Methanol as a Sustainable C1 Building Block

This study represents the first example of a manganese-catalyzed environmentally benign, practical three-component aminomethylation of activated aromatic compounds including naphtols, phenols, pyridines, indoles, carbazoles, and thiophenes in combination with amines and MeOH as a C1 source. These reactions proceed with high atom efficiency via a sequence of dehydrogenation and condensation steps which give rise to selective C-C and C-N bond formations, thereby releasing hydrogen and water. A well-defined hydride Mn(I) PNP pincer complex, recently developed in our laboratory, catalyzes this process in a very efficient way, and a total of 28 different aminomethylated products were synthesized and isolated yields of up to 91%. In a preliminary study, a related Fe(II) PNP pincer complex was shown to catalyze the methylation of 2-naphtol rather than its aminomethylation displaying again the divergent behavior of isoelectronic Mn(I) and Fe(II) PNP pincer systems.

Reaction on a solid surface - A simple, economical, and efficient Mannich reaction of azacrown ethers over graphite

Graphite brings about a rapid Mannich reaction with a range of activated and unactivated phenolic compounds such as p-cresol and p-nitrophenol. The reactions are carried out with azacrown ether and paraformaldehyde in solvent-free conditions at 100 °C for 20-30 min. The graphite powder can be reused up to three times after simple washing with acetone.

Regioselective mannich reaction of phenols under high pressure using dichloromethane as C1 unit

Regioselectivity in Mannich reaction of 4-, 3-, and 2-substituted phenols with typical heterocyclic amines are investigated under reaction conditions developed by us. Phenol and 4-alkyl, and 4-chlorophenols in the title reaction predominantly gave the corresponding 2-(aminomethyl)phenols, while 4-methoxyphenol afforded, in addition to the mono(aminomethyl)phenols, a considerable amount of the bis adducts. Peculiarly enough, 3-methylphenol with amines afforded 3-methyl-4-(aminomethyl)phenols whereas 2-methylphenol produced 2-methyl-6-(aminomethyl)phenols.

Retro-Mannich reactions of 3-alkyl-3,4-dihydro-2H-1,3-benz[e]oxazines and the synthesis of axially chiral resorcinarenes

Intermediates involved in the conversion of 3-alkyl-3,4-dihydro-2H-1,3-benz[e]oxazines into 2-N,N-dialkylaminomethylphenol derivatives, using morpholine and other high boiling secondary amines, have been identified and characterised. Additional experiments have established the involvement of o-quinone methide intermediates in the retro-Mannich reactions. Axially chiral resorcinarenes have been prepared by utilising the exchange reactions.

2-(2-Amino-2-methylpropyl)phenols by C-C-Linkage of 2-Hydroxybenzyl Alcohols with 2-Nitropropane Anions

The 2-hydroxybenzyl alcohols 1, 6, 8a, and 8e can be converted into the 2-(2-methyl-2-nitropropyl)-phenols 2, 7, and 9 by a SRN1-reaction with the sodium salt of 2-nitropropane.Catalytic hydrogenation yields the amines 3 and 10.The consequent reactions - leading to the quaternary salts 13 and 14 and as to the addition-compounds 15 and 16 - are negatively influenced by the strong steric shielding of the amino groups.