7206-57-7Relevant academic research and scientific papers
Synthesis of 1- and 2-(2-quinolyl)azulenes by the Friedlaender reaction of acetylazulenes
Mori, Takahiro,Imafuku, Kimiaki,Piao, Ming-Zhu,Fujimori, Kunihide
, p. 841 - 846 (1996)
1-Acetylazulene and 3-methyl-, 3-ethyl-, and 3-propyl-substituted 1-acetylazulenes were prepared by the reaction of 3-acetyl-2H-cyclohepta[b]furan-2-one with in situ generated enamines from aldehydes and amines. These four 1-acetylazulenes reacted with 2-aminobenzaldehyde and its 4,5-dimethoxy- and 4,5-methylenedioxy-substituted derivatives in the presence of sodium ethoxide to afford twelve 1-(2-quinolyl)azulenes. In a similar manner, three 2-(2-quinolyl)azulenes were also prepared from 2-acetylazulene.
Bicyclic compound
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Page/Page column 185, (2008/06/13)
A novel compound represented by the following formula (1) or a salt thereof: wherein symbol “A” represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two heteroatoms in the ring, a group represented by the formula A1 (R2
PYRROLIDINE DERIVATIVE OR SALT THEREOF
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Page/Page column 58, (2008/06/13)
[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).
A CONVENIENT, ONE-POT AZULENE SYNTHESIS FROM CYCLOHEPTAFURAN-2-ONES AND VINYL ETHER AND ITS ANALOGUES. (II). ACETALS AS REAGENT
Nozoe, Tetsuo,Wakabayashi, Hidetsugu,Ishikawa, Sumio,Wu, Chi-Phi,Yang, Paw-Wang
, p. 17 - 22 (2007/10/02)
Variously functionalized azulene derivatives were synthesized in one-pot and by the reaction of cycloheptafuran-2-ones with acetals of several aldehydes and ketones on heating at 160-190 deg C in neat or aprotic solvent.
