721-26-6

Usage

Uses

Used in Plastics and Rubber Industries:
META-DIISOPROPYLBENZENEDIHYDROPEROXIDE is used as a polymerization initiator and crosslinking agent for enhancing the properties of plastics and rubber materials. Its ability to generate free radicals initiates the polymerization process and promotes the formation of a network structure, improving the material's strength and durability.
Used in Curing of Unsaturated Polyester Resins:
As a curing agent, META-DIISOPROPYLBENZENEDIHYDROPEROXIDE is used in the production of unsaturated polyester resins. It initiates the curing process, leading to the formation of a rigid and stable polymer matrix, which is essential for various applications in the composite materials industry.
Used in Medical Equipment Disinfection:
META-DIISOPROPYLBENZENEDIHYDROPEROXIDE is utilized as a disinfectant for medical equipment due to its strong oxidizing properties. It effectively eliminates bacteria, viruses, and other pathogens, ensuring the cleanliness and safety of medical devices.

InChI:InChI=1/C12H18O4/c1-11(2,15-13)9-6-5-7-10(8-9)12(3,4)16-14/h5-8,13-14H,1-4H3

Synthetic route

1,3-diisopropylbenzene (99-62-7) + 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene (80-24-0) → 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6)

Conditions	Yield
With oxygen In water at 83 - 92℃; under 2250.23 Torr; for 10h; pH=9 - 11; Product distribution / selectivity;	66.1%
With oxygen; sodium formate; sodium acetate; iron(II) acetate; sodium carbonate In water at 90℃; under 2250.23 Torr; for 6h; Product distribution / selectivity;
With oxygen; sodium formate; sodium acetate; sodium carbonate In water at 90℃; under 2250.23 Torr; for 6h; Product distribution / selectivity;
With oxygen at 90℃; Product distribution / selectivity;

1,3-diisopropylbenzene (99-62-7) → 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene (80-24-0) + 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6)

Conditions	Yield
With air; sodium carbonate at 90℃;
With air; sodium carbonate at 90℃;

1,3-diisopropylbenzene (99-62-7) → 1,3-bis(1',1'-dimethylhydroxymethyl)benzene (1999-85-5) + 3-(2-hydroxy-2-propyl)-1-(2-hydroperoxy-2-propyl)benzene (13387-60-5) + 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene (80-24-0) + 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6) + 2-(3-isopropyl-phenyl)-propan-2-ol (14860-89-0)

Conditions	Yield
With oxygen; 1,10-Phenanthroline; magnesium naphthenate at 80 - 120℃; Rate constant; Kinetics; Thermodynamic data; E(act.) for various reaction products formation, other catalyst;

1,3-diisopropylbenzene (99-62-7) → 3-(2-hydroxy-2-propyl)-1-(2-hydroperoxy-2-propyl)benzene (13387-60-5) + 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene (80-24-0) + 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6)

Conditions	Yield
With oxygen; amino acids copper salts at 110℃; Product distribution; var. catalysts, selectivity of catalysts;
With oxygen at 90℃; under 2250.23 Torr; for 10h; pH=9 - 11; Product distribution / selectivity;

1,3-diisopropylbenzene (99-62-7) + oxygen (80937-33-3) → m-(2-hydroperoxy-2-propyl)acetophenone + 1,3-bis(1',1'-dimethylhydroxymethyl)benzene (1999-85-5) + 3-(2-hydroxy-2-propyl)-1-(2-hydroperoxy-2-propyl)benzene (13387-60-5) + 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6) + acetylisopropylbenzene monocarbinol (87771-41-3) + 2-(3-isopropyl-phenyl)-propan-2-ol (14860-89-0) + 1-[3-(propan-2-yl)phenyl]ethan-1-one (40428-87-3)

Conditions	Yield
With sodium hydroxide; 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene In water at 90℃;

...Expand

3-(2-hydroxy-2-propyl)-1-(2-hydroperoxy-2-propyl)benzene (13387-60-5) → m-(2-hydroperoxy-2-propyl)acetophenone + 1,3-bis(1',1'-dimethylhydroxymethyl)benzene (1999-85-5) + 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene (80-24-0) + 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6) + acetylisopropylbenzene monocarbinol (87771-41-3) + 2-(3-isopropyl-phenyl)-propan-2-ol (14860-89-0) + 1-[3-(propan-2-yl)phenyl]ethan-1-one (40428-87-3)

Conditions	Yield
With sodium hydroxide In water; 4-methyl-2-pentanone at 90℃; Heating / reflux;

3-(2-hydroxy-2-propyl)-1-(2-hydroperoxy-2-propyl)benzene (13387-60-5) → m-(2-hydroperoxy-2-propyl)acetophenone + 1,3-bis(1',1'-dimethylhydroxymethyl)benzene (1999-85-5) + 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene (80-24-0) + 1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6) + acetylisopropylbenzene monocarbinol (87771-41-3) + 2-(3-isopropyl-phenyl)-propan-2-ol (14860-89-0)

Conditions	Yield
With sodium sulfite In water; 4-methyl-2-pentanone Heating / reflux;

1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6) → acetone (67-64-1) + recorcinol (108-46-3)

Conditions	Yield
sulfur trioxide In 4-methyl-2-pentanone at 70℃; for 0.166667h; Product distribution / selectivity;	A n/a B 94%

1,3-di(2-hydroperoxy-2-propyl)benzene (721-26-6) → recorcinol (108-46-3)

Conditions	Yield
With sulfuric acid; acetone; butanone
With with acid-agent treated Fuller's earth; acetone; benzene

Upstream product

• 99-62-7 1,3-diisopropylbenzene 
• 80-24-0 3-isopropyl-1-(2-hydroperoxy-2-propyl)benzene 
• 13387-60-5 3-(2-hydroxy-2-propyl)-1-(2-hydroperoxy-2-propyl)benzene 
• 80937-33-3 oxygen 

Downstream Products

• 108-46-3 recorcinol 
• 67-64-1 acetone 

Relevant academic research and scientific papers

PROCESS FOR PRODUCTION OF DIALKYLHYDROPEROXYBENZENES

To provide a method for producing dialkylhydroperoxybenzene by liquid-phase oxidation of dialkylbenzene, wherein the method comprises the following steps, Oxidation step: a step of obtaining a oxidation reaction liquid having pH of 9 to 12, which contains dialkylhydroperoxybenzene, unreacted dialkylbenzene, and by-produced hydroperoxybenzenes by subjecting an oxidation raw material solution containing dialkylbenzene to oxidation reaction, Aqueous solution extracting step: a step of extracting the oxidation reaction liquid with an alkaline aqueous solution to obtain a water layer mainly containing dialkylhydroperoxybenzene and by-produced hydroperoxybenzenes, and an oil layer mainly containing dialkylbenzene, and Recycle step: a step of recycling and feeding at least a part of the oil layer obtained in the aqueous solution extracting step to the oxidation step, wherein the oxidation step comprises two or more reaction sections of a first section and subsequent sections arranged in series, and the temperature of the first reaction section is set to be higher than an average temperature of the whole reaction sections by 2.5°C or more.

Process for producing alkyl aromatic hydroperoxide

A process for producing an alkyl aromatic hydroperoxide, which comprises oxidizing an alkyl aromatic compound with an oxygen-containing gas in the presence of a water-soluble iron compound, wherein a concentration of the iron compound in the oxidation reaction system is 0.0001 to 10 ppm by weight in terms of iron metal.

PROCESS FOR PRODUCING PHENOLS

A process for producing a phenol, which comprises the following steps of: (1) oxidizing an alkylbenzene with an oxygen-containing gas to obtain an oxidation reaction mixture containing a hydroperoxide;(2) subjecting the oxidation reaction mixture to extraction operation with an alkaline aqueous solution to obtain an extract containing the hydroperoxide;(3) subjecting the extract obtained in the step (2) to extraction operation with an organic solvent to obtain an extract containing the hydroperoxide;(4) subjecting the extract obtained in the step (3) to water washing to obtain an oil layer containing the hydroperoxide, in which a content of the alkali has been reduced; and(5) subjecting the hydroperoxide contained in the oil layer obtained in the water washing step (4) to acidolysis to obtain a phenol,wherein a concentration of the hydroperoxide to be subjected to the water washing in the step (4), is 20% by weight or less.

PROCESS FOR PRODUCING DIHYDROXYBENZENE AND DIISOPROPYLBENZENDICARBINOL

A process for simultaneously producing a dihydroxybenzene and a diisopropylbenzene dicarbinol, which contains subjecting a diisopropylbenzene with an oxygen containing gas to obtain an oxidation reaction mixture containing a diisopropylbenzene dihydroperoxide and a diisopropylbenzene hydroxy hydroperoxide followed by an extraction separation step, a decomposition step, a distillation separation step, a reduction step and a post-treatment step in this order, the process containing purifying the diisopropylbenzene dicarbinol from the liquid containing the diisopropylbenzene dicarbinol obtained in the reduction step through purification operations containing crystallization, filtration and subsequent drying, and supplying a filtrate obtained by the filtration to the decomposition step and/or distillation separation step.

Process for the production of a dihydroxybenzene and dicarbinol from diisopropylbenzene

Improved methods for the simultaneous production of dihydroxybenzene and dicarbinol from diisopropylbenzene are provided. These methods provide for continuous and simultaneous production of diisopropylbenzene dihydroperoxide (DHP) and diisopropylbenzene hydroxyhydroperoxide (HHP) using Karr Column extractors operated in series. A very high purity DHP-containing solution, the precursor to the dihydroxybenzene, can be produced according to the reported methods. A safe and efficient method for producing dicarbinol from HHP is also disclosed.

Oxidation of m-diisopropylbenzene in the presence of chelate compounds of copper with amino acids

In the oxidation of m-diisopropylbenzene to hydroperoxides chelate compounds of copper with amino acids can play the role of catalyst or inhibitor, depending on the structure of the ligand.The copper salts of glycine, alanine, phenylalanine, threonine, and tryptophan reduce the induction period and increase the oxidation rate of diisopropylbenzene, while the copper salts of lysine, arginine, and tyrosine inhibit the process.