72358-71-5

Upstream product

• 2146-07-8 p-fluoroaniline hydrochloride 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 22752-98-3 N-Pyrid-4-yl-pyridiniumchlorid-hydrochlorid 
• 371-40-4 4-fluoroaniline 
• 7440-44-0 pyrographite 
• 626-61-9 4-Chloropyridine 
• 504-24-5 4-aminopyridine 

Downstream Products

• 98634-75-4 4-pyridine 
• 98634-76-5 4-piperidine hydrochloride 
• 98634-79-8 4-1-<4-(4-fluorophenyl)-4-oxobutyl>piperidine 
• 1374852-37-5 cyanomethyl (4-fluorophenyl)-(pyridin-4-yl)carbamodithioate 

Relevant academic research and scientific papers

Selective Functionalization of Aminoheterocycles by a Pyrylium Salt

The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.

New stable Cu(I) catalyst supported on weakly acidic polyacrylate resin for green C-N coupling: Synthesis of N-(Pyridin-4-yl)benzene amines and N,N-Bis(pyridine-4-yl)benzene amines

A method for preparation of a new stable Cu(I) catalyst supported on weakly acidic polyacrylate resin without additional stabilizing ligands is described. A simple and efficient methodology for Ullmann Cu(I) catalyzed C-N cross coupling reactions using this original catalyst is reported. Coupling reactions of 4-chloropyridinium chloride with anilines containing electron donating (EDG) or electron withdrawing (EWG) groups, naphthalen-2-amine and piperazine, respectively, are successfully demonstrated.

Chain transfer kinetics of acid/base switchable n -aryl- n -pyridyl dithiocarbamate RAFT agents in methyl acrylate, n -vinylcarbazole and vinyl acetate polymerization

The structures of the "Z" and "R" substituents of a RAFT agent (Z-C(S)S-R) determine a RAFT agent's ability to control radical polymerization. In this paper we report new acid/base switchable N-aryl-N-pyridyl dithiocarbamates (R = -CH2CN, Z = -N(Py)(Ar)) which vary in substituent at the 4-position of the aryl ring and the use of these to control molecular weight and dispersity. In their protonated form, the new RAFT agents are more effective in controlling polymerization of the more activated monomer, methyl acrylate (MA), whereas in their neutral form they provide more effective control of the polymerization of less activated monomers, N-vinyl carbazole (NVC) and vinyl acetate (VAc). For each polymerization, the apparent chain transfer coefficient (Ctrapp) shows a good correlation with Hammett parameters. Dithiocarbamates with more electron-withdrawing aryl ring substituents have the higher Ctr app. This demonstrates the influence of polar effects on C trapp and supports the hypothesis that the activity of these RAFT agents is determined by the availability of the lone pair of the dithiocarbamate nitrogen. Published 2012 by the American Chemical Society.

Neuroleptic Activity of Chiral trans-Hexahydro-γ-carbolines

A series of trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5,9b-hexahydro-1H-pyridoindoles with various N-2 substituents has been prepared and tested for neuroleptic activity (3H>spiroperidol binding and amphetamine antagonism).Several memb

Bispyridinamines: A New Class of Topical Antimicrobial Agents as Inhibitors of Dental Plaque

A series of N,N'-polyalkylenebis has been prepared, and members have been evaluated as potential anti-dental plaque agents.From among the most active members of the series, one compound, N,N'-bis(1-octanamine) dihydrochloride, octenidine, was selected as a candidate for clinical study.

Synthetic Applications of N-N Linked Heterocycles. Part 15. A Facile Synthesis of 4-Pyridyl(aryl)amines via the Reaction between 4-Chloro-1-pyridiniopyridinium Salts and Aryl Amines

4-Chloro-1-pyridiniopyridinium salts (7) and (8) react with primary and secondary arylamines to give high yields of isolable 4-aryliminium salts (9) and (10).These are readily fragmented into 4-pyridyl(aryl)amines (11) and (12) in excellent yields on treatment with sodium cyanide or sodium salts of sulphonic acids.The method fails with the more basic aliphatic amines, since these apparently attack the 2-position of the chloropyridinium ring giving products resulting from ring-opening.Mechanisms of the reactions are discussed.

Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes

Bis-[4-(R-amino)-1-pyridinium]alkanes are prepared by reacting a 4-(R-amino)pyridine with an appropriate disubstituted alkane. The compounds are useful as antimicrobial agents. Certain species are also useful as dental plaque-preventive agents.