7244-79-3

Upstream product

• 100-02-7 4-nitro-phenol 
• 10422-35-2 1-bromo-2-methyl-butane 
• 107-82-4 i-pentyl bromide 
• 123-51-3 i-Amyl alcohol 
• 2976-30-9 1-methanesulfonyl-4-nitrobenzene 
• 701-57-5 1-methylthio-4-nitro-benzene 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 5198-05-0 4-(3-methylbutoxy)aniline 
• 910-86-1 isoxyl 
• 4849-28-9 1,3-bis(4-(isopentyloxy)phenyl)urea 
• 22188-57-4 N--N'--thiocarbanilid 
• 22136-24-9 N,N'-Bis--thiocarbanilid 
• 81928-78-1 N-(4-(isopentyloxy)phenyl)acetamide 

Relevant academic research and scientific papers

Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions

A sulfonium ylide participated alkylation and arylation under transition-metal free conditions is described. The disparate reaction pattern allowed the separate activation of non-ylidic S-alkyl and S-aryl bond. Under acidic conditions, sulfonium ylides serve as alkyl cation precursors which facilitate the alkylations. While under alkaline conditions, cleavage of non-ylidic S-aryl bond produces O-arylated compounds efficiently. The robustness of the protocols were established by the excellent compatibility of wide variety of substrates including carbohydrates.

Radical Anion Promoted Chemoselective Cleavage of Csp2-S Bond Enables Formal Cross-Coupling of Aryl Methyl Sulfones with Alcohols

A novel formal cross-coupling of aryl methyl sulfones and alcohols affording alkyl aryl ethers via an SRN1 pathway is developed. Two marketed antitubercular drugs were efficiently prepared employing this approach as the key step. A dimsyl-anion initiated radical chain process was revealed as the major pathway. DFT calculations indicate that the formation of a radical anion via nucleophilic addition of alkoxide to the aryl radical is the key step in determining the observed chemoselectivity.

Chromatography-Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur

The development of a new three-component chromatography-free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.

COMPOUND, DECORATIVE MATERIAL, DECORATED ARTICLE, AND INK COMPOSITION

To provide a compound exhibiting golden glossiness and providing a film having flexibility.SOLUTION: There is provided a compound represented by the formula (1). Rand Rare each independently a substituted or unsubstituted C1 to 12 alkyl group, -(CH)-COO-R, -(CH)-O-R, -(CH)-CONH-R, -(CH)-CONH-(CH)-OH or the like; Rto Rare each independently a C1 to 6 alkyl group; nis an integer of 2 to 10; and mto mare integer of 1 to 6.SELECTED DRAWING: None

Synthesis and biological evaluation of novel IM3829 (4-(2-cyclohexylethoxy)aniline) derivatives as potent radiosensitizers

Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates the expression of over 200 genes of antioxidant and phase II drug-metabolizing enzymes, and is highly expressed in non-small cell lung cancer (NSCLC). Nine derivatives of 4-(2-cyclohexylethoxy)aniline were designed. Our previous study demonstrated that IM3829 increases radiosensitivity of several lung cancer cells in vitro and in vivo. Here, biological effects of IM3829 derivatives (2a-2i) were evaluated. Compound 2g derivative effectively inhibits mRNA and protein expression of Nrf2 and HO-1. In addition, we observed over two fold enhancement in IR-induced cell death, from 2.90 ± 0.22 to 6.02 ± 0.87, in H1299 cancer cell-line. Among the nine derivatives, compound 2g derivative exhibited the highest enhancement of radiosensitizing effect via inhibition of Nrf2 activity.

The structure-activity relationship of urea derivatives as anti-tuberculosis agents

The treatment of tuberculosis is becoming more difficult due to the ever increasing prevalence of drug resistance. Thus, it is imperative that novel anti-tuberculosis agents, with unique mechanisms of action, be discovered and developed. The direct anti-tubercular testing of a small compound library led to discovery of adamantyl urea hit compound 1. In this study, the hit was followed up through the synthesis of an optimization library. This library was generated by systematically replacing each section of the molecule with a similar moiety until a clear structure-activity relationship was obtained with respect to anti-tubercular activity. The best compounds in this series contained a 1-adamantyl-3-phenyl urea core and had potent activity against Mycobacterium tuberculosis plus an acceptable therapeutic index. It was noted that the compounds identified and the pharmacophore developed is consistent with inhibitors of epoxide hydrolase family of enzymes. Consequently, the compounds were tested for inhibition of representative epoxide hydrolases: M. tuberculosis EphB and EphE; and human soluble epoxide hydrolase. Many of the optimized inhibitors showed both potent EphB and EphE inhibition suggesting the antitubercular activity is through inhibition of multiple epoxide hydrolase enzymes. The inhibitors also showed potent inhibition of humans soluble epoxide hydrolase, but limited cytotoxicity suggesting that future studies must be towards increasing the selectivity of epoxide hydrolase inhibition towards the M. tuberculosis enzymes.

Fused ring compound and use thereof

The present invention provides a compound represented by the formula: wherein the symbols are as described in the specification, or a salt thereof, which is useful for preventing/treating eicosanoid-associated diseases such as atherosclerosis, diabetes, obesity, atherothrombosis, asthma, fever, pain, cancer, rheumatism, osteoarthritis and atopic dermatitis, and which has an excellent pharmacological action, physicochemical properties, etc.

N-glycosyl-N′-[p-(isoamyloxy)phenyl]-thiourea derivatives: Potential anti-TB therapeutic agents

Thiocarlide (THC; N,N′-bis[p-(isoamyloxy)phenyl]-thiourea; also known as Isoxyl) has been used in the past as an anti-tuberculosis agent. In an effort to improve the therapeutic value of THC, several N-glycosyl-N′-[p- (isoamyloxy)phenyl]-thiourea derivati

INHIBITORS OF MATRIX METALLOPROTEINASE

Compounds of formula (I), wherein R1 represents optionally substituted C4-12 alkyl, optionally substituted C2-6alkylaryl, or optionally substituted 5- or 6- membered aryl or heteroaryl; Z represents a bond, CH2,

EFFECT OF CHAIN BRANCHING ON MESOMORPHISM IN BROAD MOLECULES.

Two new homologous series of Schiff's bases were synthesized. The method of preparation and the liquid crystalline properties of these compounds are described. Both series are nematogenic; the smectic phase is absent even in higher members of the series. In series I, the C//2 and C//3 homologue exhibit two solid modifications. The influence of branching in the end alkoxy groups of these compounds on the mesomorphism is discussed. The mesomorphic properties of these compounds are compared with those of related compounds.