725239-16-7Relevant academic research and scientific papers
THYROID RECEPTOR LIGANDS
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Page/Page column 15, (2010/12/29)
Thyroid receptor ligands are provided which have the general formula I wherein: R1 is R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, provided that at
Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta
Hangeland, Jon J.,Doweyko, Arthur M.,Dejneka, Tamara,Friends, Todd J.,Devasthale, Pratik,Mellstroem, Karin,Sandberg, Johnny,Grynfarb, Marlena,Sack, John S.,Einspahr, Howard,Faernegardh, Mathias,Husman, Bolette,Ljunggren, Jan,Koehler, Konrad,Sheppard, Cheryl,Malm, Johan,Ryono, Denis E.
, p. 3549 - 3553 (2007/10/03)
A set of thyromimetics having improved selectivity for TR-β1 were prepared by replacing the 3′-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds ident
