72666-48-9

Upstream product

• 85502-87-0 (E)-4'-chloro-4-methoxychalcone 
• 26031-66-3 1-(2-(4-chlorophenyl)-2-oxoethyl)pyridinium bromide 
• 25357-43-1 1-(2-(4-chlorophenyl)-2-oxoethyl)-4-methylpyridinium bromide 
• 57269-96-2 2-(2-(4-chlorophenyl)-2-oxoethyl)isoquinolin-2-ium bromide 
• 99-91-2 para-chloroacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 824-94-2 p-methoxybenzyl chloride 
• 2393-23-9 4-methoxy-benzylamine 
• 104-01-8 4-Methoxyphenylacetic acid 
• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Relevant academic research and scientific papers

Copper-catalyzed efficient access to 2,4,6-triphenyl pyridinesviaoxidative decarboxylative coupling of aryl acetic acids with oxime acetates

An efficient and concise approach for the synthesis of 2,4,6-triphenyl pyridines has been developed through copper-catalysed oxidative decarboxylative coupling of C(sp3) aryl acetic acids with oxime acetates in DMF at 150 °C under an oxygen atm

Application of salicylic acid as an eco-friendly and efficient catalyst for the synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives

In this study, three eco-friendly, efficient, and convenient protocols have been reported for one-pot synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives using salicylic acid as a catalyst under solvent-free condition. The reported protocols offer several significant advantages such as the application of a nontoxic, neutral, and cheap catalyst, environmentally friendly conditions, the easy isolation of products by filtering, short reaction times, simple methodology, and good yields.

Synthesis, characterization, stereochemistry and biological evaluation of novel cyclohexanol derivatives

This research includes the synthesis of 1,5-diketone from chalcone by Michael addition of p-chloroacetophenone in the presence of NaOH (molar ratio, 1:1:10), which led to the formation of a novel cyclohexanol derivative as a side product. The above reaction was repeated with different molar ratio of chalcone-acetophenone-sodium hydroxide to set the optimum condition for maximum yield of the novel cyclohexanol derivative. The dehydration of cyclohexanol using catalytic amount of p-TsOH produced quantitative yield of corresponding cyclohexene with β,γ-unsaturation instead of apparently more stable α,β-unsaturation. The compounds were well characterized by spectroscopic techniques and elemental analysis. Their stereochemistry is discussed and newly synthesized compounds are screened for anticancer and antimicrobial activities.

Application of a novel, efficient and recyclable photo redox catalyst (Zn–Al layered double hydroxide/eosin) for the synthesis of substituted pyridine derivatives under visible light irradiation

Layered double hydroxides (LDHs) are a class of anionic clays with brucite-like layers and interlayer anions and varying in composition and morphology. LDHs show potential as supports for the immobilization of catalytically active species, to synthesize recyclable catalysts, in which catalytic sites can be preferentially orientated, highly dispersed and stabilized to afford high catalytic efficiency and recyclability in reaction media. Redox active organic dyes such as eosin Y with strong absorption in the visible region of the spectrum have been successfully used. In this work, an intercalated photo redox catalyst (Zn–Al LDH/eosin) was synthesized by co-precipitation of an aqueous solution of zinc nitrate and aluminium nitrate simultaneously with eosin Y as anionic dye. Zn–Al LDH/eosin as a recyclable catalyst was used in the reaction of various aryl ketones and benzylamines under molecular oxygen and visible light, giving good yields of substituted pyridines at room temperature. Also, the Zn–Al LDH/eosin catalyst could be reused three times without any significant changes in the reaction yields.

Synthesis and application of chitosan supported vanadium oxo in the synthesis of 1,4-dihydropyridines and 2,4,6-triarylpyridines: Via anomeric based oxidation

Chitosan, as a biopolymer, exhibits a strong affinity for complexation with suitable metal ions. Thus, it has received increased attention for the preparation of stable bioorganic-inorganic hybrid heterogeneous catalysts. Herein, a novel chitosan based vanadium oxo (ChVO) catalyst was prepared and fully characterized by several techniques such as Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), derivative thermal gravimetric (DTG), differential thermal analysis (DTA), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma mass spectrometry (ICP-MS). The synthesized catalyst has been successfully used as a reusable catalyst in the synthesis of dihydropyridines and triarylpyridines.

Copper(II) supported on magnetic chitosan: A green nanocatalyst for the synthesis of 2,4,6-triaryl pyridines by C-N bond cleavage of benzylamines

In this paper, Cu/magnetic chitosan has been synthesized and used as a new green nanocatalyst for highly efficient synthesis of 2,4,6-triaryl pyridines via C-N bond cleavage of benzylamines under aerobic oxidation at 90 °C. The chemical and structural properties of the synthesized catalyst were determined by scanning electron microscopy, energy-dispersive X-ray, X-ray powder diffraction, thermogravimetric analysis and flame atomic absorption spectroscopies. It is found that the catalyst can be easily separated from the reaction mixture by an external magnetic field and recycled several times without a significant loss in activity.

Synthesis of 2,4,6-Trisubstituted Pyridines by Oxidative Eosin y Photoredox Catalysis

Eosin Y, an organic dye, was activated as a photoredox catalyst in the presence of molecular oxygen using visible light and, when it was used in the reaction of aryl ketones and benzyl amines, afforded good yields (52-87%) of 2,4,6-triarylpyridines (21 examples) at ambient temperature. The aryl groups at the 2- and 6-positions are derived from ketones, while benzyl amine plays the dual role of providing an aryl functionality at the 4-position of pyridine as well as being a nitrogen donor.

An Efficient Synthesis of 2,4,6-Triarylpyridines by Use of Benzyl Halides under Neat Conditions

An efficient synthesis of 2,4,6-triarylpyridines is described. Heating a mixture of an acetophenone, a benzyl halide, and ammonium acetate under neat conditions afforded the corresponding Kr?hnke pyridines in excellent yields.

Magnetic MIL-101-SO3H: A highly efficient bifunctional nanocatalyst for the synthesis of 1,3,5-triarylbenzenes and 2,4,6-triaryl pyridines

A magnetic MIL-101-SO3H was synthesized and successfully used as a highly active nanocatalyst for the synthesis of 1,3,5-triarylbenzenes and 2,4,6-triaryl pyridines. The prepared nanocatalyst was characterized by Fourier transform infrared spec

Ultrasound-Mediated Synthesis of 2,4,6-Triaryl-Pyridines Using MgAl2O4 Nanostructures

Nanocrystalline MgAl2O4 was found to be a highly efficient catalyst for the preparation of 2,4,6-triaryl-pyridines from the reaction of acetophenone derivatives, aryl aldehydes, and ammonium acetate under sonic condition for the first time. The present methodology offers several advantages, such as excellent yields, simple procedure, shorter reaction times, and milder conditions; the catalyst also exhibited remarkable reusable activity. This procedure is much simpler and faster than the protocols published to date.