72734-76-0

Basic information

• Product Name: 4-acetylphenyl 2,2-dimethylpropanoate
• Synonyms: 4-Acetylphenyl pivalate; propanoic acid, 2,2-dimethyl-, 4-acetylphenyl ester
• CAS NO: 72734-76-0
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.2643
• Mol File: 72734-76-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 322.7°C at 760 mmHg
• Flash Point: 139.9°C
• Density: 1.058g/cm³
• Vapor Pressure: 0.000275mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: 4-acetylphenyl 2,2-dimethylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetylphenyl 2,2-dimethylpropanoate(72734-76-0)
• EPA Substance Registry System: 4-acetylphenyl 2,2-dimethylpropanoate(72734-76-0)

Safety Data

• Hazardous Substances Data: 72734-76-0(Hazardous Substances Data)

Upstream product

• 99-90-1 para-bromoacetophenone 
• 75-98-9 Trimethylacetic acid 
• 1184-88-9 sodium pivalate 
• 1352413-16-1 C₁₂H₁₃F₃O₅S 
• 3282-30-2 pivaloyl chloride 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 35294-37-2 1-(4-(thiophen-2-yl)phenyl)ethanone 
• 1304688-79-6 4-(4-acetylphenyl)-1-phenylbutan-1-one 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 98-86-2 acetophenone 

Relevant articles and documents

General Paradigm in Photoredox Nickel-Catalyzed Cross-Coupling Allows for Light-Free Access to Reactivity

Self-sustained NiI/III cycles are established as a potentially general paradigm in photoredox Ni-catalyzed carbon–heteroatom cross-coupling reactions through a strategy that allows us to recapitulate photoredox-like reactivity in the absence of light across a wide range of substrates in the amination, etherification, and esterification of aryl bromides, the latter of which has remained, hitherto, elusive under thermal Ni catalysis. Moreover, the accessibility of esterification in the absence of light is especially notable because previous mechanistic studies on this transformation under photoredox conditions have unanimously invoked energy-transfer-mediated pathways.

Nickel-Mediated Trifluoromethylation of Phenol Derivatives by Aryl C?O Bond Activation

The increasing pharmaceutical importance of trifluoromethylarenes has stimulated the development of more efficient trifluoromethylation reactions. Tremendous efforts have focused on copper- and palladium-mediated/catalyzed trifluoromethylation of aryl halides. In contrast, no general method exists for the conversion of widely available inert electrophiles, such as phenol derivatives, into the corresponding trifluoromethylated arenes. Reported herein is a practical nickel-mediated trifluoromethylation of phenol derivatives with readily available trimethyl(trifluoromethyl)silane (TMSCF3). The strategy relies on PMe3-promoted oxidative addition and transmetalation, and CCl3CN-induced reductive elimination. The broad utility of this transformation has been demonstrated through the direct incorporation of trifluoromethyl into aromatic and heteroaromatic systems, including biorelevant compounds.

TRIPHENYLETHYLENE COMPOUNDS AND USES THEREOF

Triphenylethylene compounds as dual aromatase inhibitors and selective estrogen receptors modulators are described. Also described are methods for treating patients of breast cancers, and patients of breast cancer comorbid with osteoporosis, using the des