35294-37-2

Basic information

• Product Name: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE
• Synonyms: 1-[4-(2-THIENYL)PHENYL]ETHANONE;1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE;AKOS BAR-0220;4-(2-THIENYL)ACETOPHENONE;1-(4-THIEN-2-YLPHENYL)ETHANONE;1-[4-(thiophen-2-yl)phenyl]ethan-1-one
• CAS NO: 35294-37-2
• Molecular Formula: C₁₂H₁₀OS
• Molecular Weight: 202.27
• Mol File: 35294-37-2.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 323 °C at 760 mmHg
• Flash Point: 149.1 °C
• Appearance: /
• Density: 1.151 g/cm³
• CAS DataBase Reference: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE(35294-37-2)
• EPA Substance Registry System: 1-(4-THIOPHEN-2-YL-PHENYL)-ETHANONE(35294-37-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 35294-37-2(Hazardous Substances Data)

Usage

General Description

1-(4-thiophen-2-yl-phenyl)-ethanone, also known as thiophene-2-phenyl-1-ethanone, is an organic compound with the molecular formula C14H12OS. It is a ketone with a thiophene ring and a phenyl ring attached to an ethanone group. This chemical is used in various industries as a building block for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of dyes, pigments, and as a flavoring agent in the food industry. The compound has a strong odor and is a flammable liquid, requiring proper handling and storage. Due to its potential health hazards, it is important to follow safety protocols when working with 1-(4-thiophen-2-yl-phenyl)-ethanone.

Upstream product

• 188290-36-0 thiophene 
• 99-90-1 para-bromoacetophenone 
• 5980-89-2 di-[2]thienyl-mercury 
• 13329-40-3 4-Iodoacetophenone 
• 6165-68-0 thiophene boronic acid 
• 99-91-2 para-chloroacetophenone 
• 1003-09-4 2-bromothiophene 
• 149104-90-5 4-acetylphenylboronic acid 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 15106-95-3 bis(thien-2-yl)zinc 
• 96-43-5 2-thienyl chloride 
• 40133-22-0 2-(4-bromophenyl)thiophene 
• 13411-48-8 1-(trimethylsilyl)ethanone 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 128746-80-5 2-bromo-1-[4-(2-thienyl)phenyl]-1-ethanone 
• 1060772-73-7 2-bromo-5-(4-bromoacetylphenyl)thiophene 
• 1186236-78-1 piperidine-1-carboxylic acid 1-(4-thiophen-2-yl-phenyl)vinyl ester 

Relevant articles and documents

Polyglycerol as a high-loading support for boronic acids with application in solution-phase Suzuki cross-couplings

In this paper, we describe the usage of a soluble high-loading polyglycerol support for functionalized boronic acids without further linker design. The quantitatively formed polyglycerol boron esters were subsequently employed in homogeneous Suzuki cross-coupling reactions to give high yields (84-91%) of functional biaryls with minimal amounts of the Pd catalyst (0.2 mol %). In situ precipitation and ultrafiltration were used as simple and effective purification protocols. Furthermore, the reaction conditions were optimized by the choice of the solvent and the catalyst.

Organozinc-mediated direct cross-coupling under microwave irradiation

We report a direct cross-coupling reaction between (het)aryl pivalates/tosylates and di(het)arylzinc species in 2-methyltetrahydrofuran/N-methyl pyrrolidone (1:1), which occurs via C–O bond cleavage under microwave irradiation. The reaction takes place smoothly in short reaction times without the addition of any catalyst or ligand. The reaction is suitable for a broad scope of substrates and exhibits good functional group compatibility, utilizes a simple work-up procedure, and gives the desired products in high purity.

Palladium-catalyzed acetylation of arylbromides

-