7287-06-1

Upstream product

• 502-49-8 cycloactanone 
• 16538-85-5 phenylcyclooctane 
• 108-86-1 bromobenzene 
• 100-59-4 phenylmagnesium chloride 
• 100-58-3 phenylmagnesium bromide 
• 696-71-9 cyclooctanol 
• 749893-57-0 1-propylcyclooctanol 

Downstream Products

• 59358-73-5 1,1'-Diphenyl-1,1'-bicyclooctyl 
• 16538-85-5 phenylcyclooctane 
• 1674-37-9 n-octanophenone 
• 137407-47-7 (E)-1-phenylcyclooctene 
• 76393-73-2 1-phenylcyclooctyl cation 
• 79798-02-0 1-phenylcyclooctyl azide 
• 14630-74-1 1-phenyl-4-cycloocten-1-ol 
• 14573-46-7 8-iodo-1-phenyloctan-1-one 
• 78712-57-9 8-bromo-1-phenyloctan-1-one 
• 25328-90-9 1-phenylcyclooct-1-ene 
• 65-85-0 benzoic acid 
• 92-52-4 biphenyl 

Relevant academic research and scientific papers

Iodobenzene-catalyzed oxidative cleavage of olefins to carbonyl compounds

A metal-free approach for the oxidative cleavage of carbon–carbon double bonds of olefins to carbonyl compounds was established by using oxidant m-CPBA and non-metallic organocatalyst PhI in toluene/H2O. A broad scope of aromatic olefins was used. All the reactions proceeded smoothly at 35 °C in short reaction time to furnish the respective mono- and double carbonyl compounds selectively in moderate to good yields.

Triphosgene and DMAP as Mild Reagents for Chemoselective Dehydration of Tertiary Alcohols

The utility of triphosgene and DMAP as mild reagents for chemoselective dehydration of tertiary alcohols is reported. Performed in dichloromethane at room temperature, this reaction is readily tolerated by a broad scope of substrates, yielding alkenes preferentially with the (E)-geometry. While formation of the Hofmann products is generally favored, a dramatic change in alkene selectivity toward the Zaitzev products is observed when the reaction is carried out in dichloroethane at reflux.

NOVEL COMPOUNDS 514

The invention provides compounds of formula (I), wherein R1, R2, R3, R4, R5, g, h and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing the

QUINICLIDINE DERIVATIVES OF (HETERO) ARYLCYCLOHEPTANECARBOXYLIC ACID AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention provides compounds of formula (I) wherein R4 is a group of formula (II) or (IIIa) or (IIIb) and R1, R2, R3, R5, a, b and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation (I), (II), (IIIa), (IIIb).

Photolysis of 1-alkylcycloalkanols in the presence of (diacetoxyiodo) benzene and I2. Intramolecular selectivity in the β-scission reactions of the intermediate 1-alkylcycloalkoxyl radicals

The C-C β-scission reactions of 1-alkylcycloalkoxyl radicals, generated photochemically by visible light irradiation of CH2Cl 2 solutions containing the parent 1-alkylcycloalkanols, (diacetoxy)-iodobenzene (DIB), and I2, have been investigated through the analysis of the reaction products. The 1-alkylcycloalkoxyl radicals undergo competition between ring opening and C-alkyl bond cleavage as a function of ring size and of the nature of the alkyl substituent. With the 1-propylcycloheptoxyl, 1-propylcyclooctoxyl, and 1-phenylcyclooctoxyl radicals, formation of products deriving from an intramolecular 1,5-hydrogen atom abstraction reaction from the cycloalkane ring has also been observed. The results are discussed in terms of release of ring strain associated to ring opening, stability of the alkyl radical formed by C-alkyl cleavage, and with cycloheptoxyl and cyclooctoxyl radicals, also in terms of the possibility of achieving a favorable geometry for intramolecular hydrogen atom abstraction.

Oxidative fragmentation of 1-aryl-1-cycloalkenes using cerium(IV) ammonium nitrate (CAN): Some novel observations

1-Phenyl-1-cycloalkenes undergo oxidative fragmentation in presence of CAN in methanol, affording 1,n-dicarbonyl compounds as the major products along with 1,2-dimethoxycycloalkanes. The reaction under deoxygenated conditions afforded the latter in good yields. In the presence of azide ion, fragmentation leading to the corresponding cyanoketones was observed whereas with sulfinate only the 1-methoxy-2-sulfonyl cycloalkanes were formed.

Synthesis of Certain Mesogenic Azomethines Derived from 4-Cycloalkylanilines and from 4-Cycloalkylbenzaldehydes

General procedures are described for the synthesis of members of five pairs of related homologous series of mesogenic azomethines differing in the mode of linkage of the CH=N group and containing a cycloalkyl group in a terminal position.

Thermochemistry of Strained Cycloalkenes: Experimental and Computational Studies

Pulsed time-resolved photoacoustic calorimetry in combination with quantum yield determinations afforded the relaxed triplet energy of 1-phenylcyclooctene and the energy of geometric isomerization of cis-1-phenylcyclooctene.These values are combined with

Studies on the Oxidation of Phenyl Cycloalkanes by Tertiary Hydroperoxides

During the thermal decomposition of cumene hydroperoxide at about 125 deg C in phenyl cycloalkanes as solvents, the solvents are attacked, preferably at the tertiary C-H bonds.Up to 70percent (with regard to the decomposed hydroperoxide) of oxidation products of the phenyl cycloalkanes are obtained.The main oxidation products are the corresponding 1-phenyl cycloalkanols, but relatively large amounts of phenyl alkyl ketones with the same number of carbon atoms are also formed, probably via a further oxidation of the 1-phenyl cycloalkanols.

CH ACIDITY OF SUBSTITUTED CYCLOALKANES. IV. EFFECT OF THE SIZE OF THE ALKANE RING AND THE STRENGTH OF THE BASE ON THE KINETICS OF IONIZATION OF PHENYLCYCLOALKANES

The rate constants (k) for the ionization of phenylcycloalkanes (C3-C8) were determined in solutions of lithium cyclohexylamide in cyclohexylamine and of potassium tert-butoxide and dimsylpotassium in DMSO.The dependence of k on the strength of the broken