73130-06-0

Basic information

• Product Name: 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole
• Synonyms: 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole
• CAS NO: 73130-06-0
• Molecular Weight: 298.365
• Mol File: 73130-06-0.mol

Chemical Properties

• CAS DataBase Reference: 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole(73130-06-0)
• EPA Substance Registry System: 3-phenyl-1-(toluene-4-sulfonyl)-1H-pyrazole(73130-06-0)

Safety Data

• Hazardous Substances Data: 73130-06-0(Hazardous Substances Data)

Upstream product

• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 13829-77-1 3-(trimethylsilyl)-1-phenyl-2-propyn-1-one 
• 2458-26-6 3-phenylpyrazole 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-86-2 acetophenone 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 197093-31-5 N-tosyl-N-(1-phenyl-1-propyn-3-yl)hydrazine 
• 19555-13-6 2-(dimethylamino)malononitrile 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 
• 62460-99-5 (E)-4-methyl-N′-(1-phenylethylidene)benzenesulfonohydrazide 
• 197093-16-6 N-tosyl-N-propargylhydrazine 
• 591-50-4 iodobenzene 

Downstream Products

• 2458-26-6 3-phenylpyrazole 

Relevant articles and documents

Synthesis of N-Sulfonyl Pyrazoles Through Cyclization Reactions of Sulfonyl Hydrazines with Enaminones Promoted by p-TSA

A strategy for the rapid synthesis of 3-substituted N-sulfonyl pyrazoles via p-TSA-promoted cyclization reactions of sulfonyl hydrazines with N,N-dimethyl enaminones has been developed. This method achieves both the formation of pyrazole ring and the cont

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: An efficient strategy for the synthesis of substituted 1-tosyl-1: H -pyrazoles

A Zn(OTf)2-promoted cyclization reaction of tosylhydrazones with 2-(dimethylamino)malononitrile has been successfully developed providing an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.

Method for synthesis of substituted 1-sulfonyl-1H-pyrazole

The invention discloses a method for synthesis of substituted 1-sulfonyl-1H-pyrazole, and aims to provide a method for synthesis of 1-sulfonyl-1H-pyrazole, the method has the advantages of simple and easily available starting materials, high yield and easy operation, the method is characterized in that sulfonyl hydrazone, N, N-dimethylmalononitrile and a Lewis acid catalyst are in turn added into an organic solvent for heating refluxing reaction to obtain the substituted 1-sulfonyl-1H-pyrazole, and the method belongs to the organic synthesis technical field.

Synthesis of sulfonamides from azoles and sodium sulfinates at ambient temperature

NBS or NIS mediated direct S[sbnd]N bond formation between azoles and sodium sulfinates is described. The reaction shows good substrate scope and tolerates a wide range of functionalities in both azoles and sodium sulfinate substrates. Pyrazoles are also suitable for this method, various 4-halopyrazoles derivatives were obtained by using N-halosuccinimide (NXS) as the halogen source.

Base-promoted ecofriendly synthesis of trisubstituted pyrazoles from α,β-alkynyl N-tosylhydrazones under metal- and solvent-free conditions

A simple and green method is described for the synthesis of trisubstituted pyrazoles from α,β-alkynyl N-tosylhydrazones under metal- and solvent-free conditions. Notably, only diisopropylamine is required as a promoter, and the reaction can be easily perf

Chemoselective synthesis of substituted pyrazoles through AgOTf-catalyzed cascade propargylic substitution-cyclization-aromatization

A cascade AgOTf-catalyzed chemoselective approach to 3,5/1,3-disubstitued pyrazoles from propargylic alcohols and para-tolylsulfonohydrazide has been developed. Good chemoselectivity is observed depending on the different substituents in the alkyne moiety of the propargylic alcohols, generating two different kinds of products through different aromatization mechanisms. The pyrazolo[5,1-a]isoquinoline skeleton can also be effectively constructed by this method through a cascade bicyclization process.

Functionalised Pyrazoles through a Facile One-Pot Procedure from N-Tosyl-N-propargylhydrazine and Aryl Iodides or Vinyl Triflates

Functionalised pyrazoles have been prepared in good overall yield through a facile one-pot procedure. The synthesis includes the palladium-catalysed coupling of the readily available N-tosyl-N-propargylhydrazine with aryl iodides or vinyl triflates, the palladium-catalysed annulation of the resulting N-tosyl-N-(1-aryl/vinyl-1-propyn3-yl)hydrazine and exposure of the reaction mixture arising from the annulation step to KOBut.