7319-45-1

Usage

Uses

Used in Pharmaceutical Industry:
5-Benzyl-2,4-diaminopyrimidine is used as a building block for the synthesis of various drugs and medications. Its unique structure allows it to be a key component in the development of new therapeutic agents.
Used in Medicinal Treatments:
5-Benzyl-2,4-diaminopyrimidine has been studied for its potential use in the treatment of certain medical conditions, including cancer and infectious diseases. Its role in these treatments is attributed to its chemical properties that can be harnessed to target specific biological processes.
Used in Organic Chemistry:
5-Benzyl-2,4-diaminopyrimidine may also have applications in the field of organic chemistry, where it can be utilized in the creation of novel molecules and materials with specific properties and functions. Its versatility in chemical reactions makes it a valuable component in designing new organic compounds.
Further Research:
However, further research is needed to fully understand the potential uses and applications of 5-Benzyl-2,4-diaminopyrimidine. As our understanding of 5-Benzyl-2,4-diaminopyrimidine grows, so too may its applications in various industries and scientific fields.

InChI:InChI=1/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)

Upstream product

• 259683-41-5 5-benzyl-4-chloro-pyrimidin-2-ylamine 
• 50-01-1 guanidine hydrochloride 
• 121242-99-7 (E)-2-Benzyl-3-phenylamino-acrylonitrile 
• 98516-80-4 ethyl 2-formyl-3-phenylpropionate 
• 18493-83-9 5-benzyluracil 
• 76651-70-2 (E)-2-Benzyl-3-morpholin-4-yl-acrylonitrile 
• 100-52-7 benzaldehyde 
• 82870-68-6 5-benzyl-2,4-dichloro-pyrimidine 
• 873409-32-6 2-amino-5-benzylpyrimidin-4(3H)-one 

Downstream Products

• 69945-52-4 5-(4-Nitro-benzyl)-pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

Folate-Synthesizing Enzyme System as Target for Development of Inhibitors and Inhibitor Combinations against Candida albicans - Synthesis and Biological Activity of New 2,4-Diaminopyrimidines and 4′-Substituted 4-Aminodiphenyl Sulfones

The paper describes the design, synthesis, and testing of inhibitors of folate-synthesizing enzymes and of whole cell cultures of Candida albicans. The target enzymes used were dihydropteroic acid synthase (SYN) and dihydrofolate reductase (DHFR). Several series of new 2,4-diaminopyrimidines were synthesized and tested as inhibitors of DHFR and compared with their activity against DHFR derived from mycobacteria and Escherichia coli. To test for selectivity, also rat DHFR was used. A series of substituted 4-aminodiphenyl sulfones was tested for inhibitory activity against SYN and the I50 values compared to those obtained previously against Plasmodium berghei- and E. coll-derived SYN. Surprisingly, QSAR equations show very similar structural dependencies. To find an explanation for the large difference in the I50 values observed for enzyme inhibition (SYN, DHFR) and for inhibition of cell cultures of Candida, mutant strains with overexpressed efflux pumps and strains in which such pumps are deleted were included in the study and the MICs compared. Efflux pumps were responsible for the low activity of some of the tested derivatives, others showed no increase in activity after pumps were knocked out. In this case it may be speculated that these derivatives are not able to enter the cells.