732250-35-0

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4R)-
• CAS NO: 732250-35-0
• Molecular Formula: C15H12O2
• Molecular Weight: 224.259
• Mol File: 732250-35-0.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4R)-(732250-35-0)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4R)-(732250-35-0)

Safety Data

• Hazardous Substances Data: 732250-35-0(Hazardous Substances Data)

Upstream product

• 16618-72-7 3-phenyl-1-indanone 
• 118-93-4 o-hydroxyacetophenone 
• 58972-42-2 1-(2-hydroxyphenyl)-1-phenyl-ethanol 
• 39477-86-6 1-phenyl-1-(2-hydroxyphenyl)ethene 
• 201230-82-2 carbon monoxide 
• 91-64-5 coumarin 
• 98-80-6 phenylboronic acid 
• 1864-94-4 phenyl formate 
• 144017-77-6 (E)-1-(2-chlorophenyl)-3-phenylprop-2-en-1-one 
• 300657-41-4 (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one 
• 634182-03-9 (R)-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1448854-19-0 (R)-3-(2-(benzyloxy)phenyl)-3-(4-chlorophenyl)propanal 
• 52205-01-3 (5-methyl-2-phenyl-[1,3,2]dioxaborinan-5-yl)-methanol 

Relevant articles and documents

Ir-catalyzed asymmetric hydrogenation of 3-arylindenones for the synthesis of chiral 3-arylindanones

An efficient synthesis of chiral 3-arylindanones via iridium-catalyzed asymmetric hydrogenation of 3-arylindenones has been developed. The reaction showed good compatibility with various functional groups, delivering a variety of 3-arylindanones in excellent yields and with good enantioselectivities. The reaction was also carried out on a gram-scale, delivering the product in quantitative yield. In addition, the products can be easily derivatized and transformed into natural products and pharmaceutical agents.

Organic Solvent-free Asymmetric 1,4-Addition in Liquid- or Solid-State using Conventional Stirring Catalyzed by a Chiral Rhodium Complex Developed as a Homogeneous Catalyst

Organic solvent-free asymmetric 1,4-addition of arylboronic acids to enone substrates was performed by using a chiral rhodium complex catalyst developed as a homogeneous catalyst. Reactions catalyzed by [RhOH(cod)]2 with chiral diphosphine ligands in liquid- or solid-state proceeded to give chiral 1,4-adducts in high yield with enantioselectivities up to ca. 100 % ee by conventional stirring without mechanochemistry such as ball milling. The solid-state reactions under a static condition also proceeded, but with a slight decrease in enantioselectivity of the 1,4-adduct. SEM observations of the solid-state reactions indicated that no nanoparticles catalyst was generated. The organic solvent-free reaction could be applied to gram-scale synthesis by performing a greener purification using a minimum necessary organic solvent.

The second-generation synthesis of BICMAP analogues

We previously reported the synthesis of BICMAP (1a) via 6-diphenylphosphino-2,3-dihydrobenzofuran as a key intermediate. However, we did not successfully synthesize BICMAP analogues via a similar synthetic route. Herein we report the second-generation syn