73402-88-7Relevant academic research and scientific papers
Synthesis of quinolines: Via sequential addition and I2-mediated desulfurative cyclization
Gao, Ziwei,Jian, Yajun,Sun, Huaming,Wang, Yanyan,Yang, Mingming,Zhang, Guofang,Zhang, Weiqiang
supporting information, p. 38889 - 38893 (2021/12/20)
An efficient one-pot approach for the synthesis of quinolines from o-aminothiophenol and 1,3-ynone under mild conditions is disclosed. With the aid of ESI-MS analysis and parallel experiments, a three-step mechanism is proposed - a two-step Michael additi
Quinoline compound and synthesis method thereof
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Paragraph 0077-0082, (2020/02/14)
The invention discloses a synthesis method of a quinoline compound. The synthesis method comprises the following steps: adding a diazocarbonyl compound and a 2-vinylaniline compound into a solvent, carrying out a reaction under the protection of an inert
MOF-5 as a highly efficient and recyclable catalyst for one pot synthesis of 2,4-disubstituted quinoline derivatives
Di, Jia-Qi,Ma, Cui-Ting,Xiao, Song-Tao,Zhang, Zhan-Hui
, p. 8614 - 8620 (2020/06/09)
A MOF-5-catalyzed three-component coupling reaction was developed as an efficient approach for the synthesis of 2,4-disubstituted quinoline derivatives via a one pot three-component reaction of aromatic amines, aldehydes and alkynes with excellent yields. The easy recovery and reusability of the catalyst, broad substrate scope, short reaction time, high yields of products and solvent-free conditions make this protocol practical, environmentally friendly and economically attractive.
A Tf2O-Promoted Synthesis of Functionalized Quinolines from Ketoximes and Alkynes
Zheng, Weiping,Yang, Weiguang,Luo, Dongping,Min, Lin,Wang, Xinyan,Hu, Yuefei
supporting information, p. 1995 - 1999 (2019/03/13)
A new general synthesis of quinolines was developed from ketoximes and alkynes in the presence of Tf2O. It offered the first direct synthesis of quinolines by using the nitrilium salts generated in situ from a Tf2O-promoted Beckmann rearrangement of ketoximes under very easy conditions. (Figure presented.).
Establishing the correlation between catalytic performance and N→Sb donor-acceptor interaction: Systematic assessment of azastibocine halide derivatives as water tolerant Lewis acids
Lei, Jian,Peng, Lingteng,Qiu, Renhua,Liu, Yongping,Chen, Yi,Au, Chak-Tong,Yin, Shuang-Feng
, p. 8478 - 8487 (2019/06/19)
A series of organoantimony(iii) halide complexes with a tetrahydrodibenzo[c,f][1,5]azastibocine framework were synthesized and employed as water tolerant Lewis acid catalysts. The results of a systematic structure-activity relationship study demonstrated that the strength of N→Sb donor-acceptor interaction could be synergistically modulated by tuning the properties of the nitrogen substituents and halogen atoms adjacent to the central antimony atom, and consequently resulted in distinct catalytic performances towards organic reactions such as Mannich, cross-condensation, cyclization-aromatization and epoxide aminolysis reaction. The fluorinated organoantimony(iii) derivatives were found to be more active than those of the chlorinated, brominated and iodinated analogues, owing to the use of an Sb-F moiety as a hydrogen bond acceptor. By comparison, the compound 6-cyclohexyl-12-fluoro-5,6,7,12-tetrahydrodibenzo[c,f][1,5] azastibocine (1d) is found to exhibit the highest catalytic activity, together with facile reusability in scale enlarged synthesis.
Method for preparing quinoline compounds under catalysis of zirconocene dichloride
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Paragraph 0016-0023; 0048-0053; 0040-0043, (2019/09/14)
The invention discloses a method for preparing quinoline compounds under catalysis of zirconocene dichloride. According to the method, 3-butyne-2-one compounds and an o-aminophenylmercaptan compound are taken as raw materials, zirconium dichloride is take
Manganese(ii)-catalysed dehydrogenative annulation involving C-C bond formation: highly regioselective synthesis of quinolines
Wang, Chengniu,Yang, Jinfei,Meng, Xiao,Sun, Yufeng,Man, Xuyan,Li, Jinxia,Sun, Fei
supporting information, p. 4474 - 4478 (2019/04/05)
An inexpensive nontoxic manganese(ii)-catalysed dehydrogenative annulation was developed for C-C bond formation. The reaction showed high selectivity and efficiency across a broad substrate scope. Remarkably simple conditions and the ability to conduct gram-scale synthesis underscore this method's utility. To demonstrate the potential of this approach, we tested the drug effects of compound 3n, which showed activity for blocking vascular development. The results of this study will be important for the treatment of eye diseases and tumors caused by vascular proliferation.
Quinoline-containing skeleton compound and preparation method and applications thereof
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Paragraph 0027-0031, (2019/11/04)
The invention discloses a quinoline-containing skeleton compound and a preparation method thereof. A structural formula of the compound is represented by a formula I shown in the description. According to the invention, a series of quinoline derivatives are efficiently and rapidly synthesized by adopting cheap metal catalysis technology. The compound has a pharmaceutical effect on nervous system diseases and vascular system diseases, and broadens a treatment range of quinoline medicine.
COMPOUND AND ORGANIC ELECTRONIC DEVICE COMPRISING SAME
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Paragraph 0189-0191; 0229-0230, (2018/07/04)
The present specification relates to a compound and an organic electronic device including the same.
Acid-promoted iron-catalysed dehydrogenative [4 + 2] cycloaddition for the synthesis of quinolines under air
Yang, Jinfei,Meng, Xiao,Lu, Kai,Lu, Zhihao,Huang, Minliang,Wang, Chengniu,Sun, Fei
, p. 31603 - 31607 (2018/09/25)
An acid-promoted iron-catalysed dehydrogenative [4 + 2] cycloaddition reaction was developed for the synthesis of quinolines using air as a terminal oxidant. Acetic acid was the best cocatalyst for the cycloaddition of N-alkyl anilines with alkenes or alk
