73430-27-0

Basic information

• Product Name: Ethenamine, N,N-dimethyl-2-nitro-, (1E)-
• Synonyms: N,N-dimethyl-(2-nitrovinyl)amine;1-dimethylamino-2-nitroethene;(E)-1-dimethylamino-2-nitroethylene;N,N-dimethyl-2-nitroetheneamine;1-dimethylamino-2-nitroethylene
• CAS NO: 73430-27-0
• Molecular Formula: C4H8N2O2
• Molecular Weight: 116.12
• Mol File: 73430-27-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Ethenamine, N,N-dimethyl-2-nitro-, (1E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethenamine, N,N-dimethyl-2-nitro-, (1E)-(73430-27-0)
• EPA Substance Registry System: Ethenamine, N,N-dimethyl-2-nitro-, (1E)-(73430-27-0)

Safety Data

• Hazardous Substances Data: 73430-27-0(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 32115-55-2 N,N-Dimethylcarbamidsaeure-trimethylsilylester 
• 93696-69-6 2,2-Difluornitroethan 
• 68-12-2 N,N-dimethyl-formamide 
• 124-40-3 dimethyl amine 
• 122-51-0 orthoformic acid triethyl ester 
• 120539-85-7 ((E)-2-Nitro-vinylsulfanyl)-benzene 
• 105-45-3 acetoacetic acid methyl ester 
• 58261-64-6 α-nitro-β-dimethylaminoacrolein 
• 126-81-8 dimedone 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 89712-45-8 N,N-dimethylformamide dimethyl sulfate adduct 
• 1783-25-1 N₁,N₁-dimethyl-N₂-phenylformamidine 

Downstream Products

• 56813-80-0 3,5-dinitro-1,1′-biphenyl 
• 5539-25-3 1-Nitro-4-phenyl-buten-2-on-4 
• 122631-43-0 (E)-3-(2-nitrovinyl)-2-phenyl-1H-indole 
• 151889-00-8 5-Methoxy-3-((E)-2-nitro-vinyl)-2-phenyl-1H-indole 
• 90322-06-8 dimedone potassium salt 
• 61675-19-2 (E)-3-(2-nitroethenyl)-5-methoxyindole 
• 61-54-1 tryptamine 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 3610-36-4 2-(6-methoxy-1H-indol-3-yl)ethanamine 
• 3764-94-1 5-chlorotryptamine 
• 3610-42-2 5-bromotryptamine 
• 174707-03-0 (1,3-diphenyl-2-propenyl)-nitromethane 
• 23077-59-0 6-fluoro-3-(2-nitrovinyl)-1H-indole 
• 61675-19-2 5-methoxy-3-(2-nitroethylenyl)-1H-indole 

Relevant articles and documents

Method for synthesizing 2-amino-5-nitrothiazole

The invention discloses a method for synthesizing 2-amino-5-nitrothiazole, which comprises the following steps: (1) in an inert atmosphere, adding diethylamine, acetyl chloride and triethyl orthoacetate into a reaction container, uniformly mixing, stirring to react for 12-24 hours, and distilling and purifying the reaction product to obtain N, N-dimethylformamide dimethyl acetal, (2) in an inert atmosphere, mixing N, N-dimethylformamide dimethyl acetal with nitromethane, heating the mixture to 80-100 DEG C for reflux reaction, carrying out reduced pressure distillation on the reaction productto remove the solvent, and purifying to obtain N, N-dimethyl nitroethylene, and (3) in an inert atmosphere, putting N, N-dimethyl nitroethylene into a reaction container, sequentially adding ethanol,liquid bromine and thiourea, reacting at room temperature, after the reaction is finished, filtering a reactant, washing with ice ethanol, drying to obtain a white solid, adding water, and filtering to obtain the 2-amino-5-nitrothiazole. According to the method for synthesizing 2-amino-5-nitrothiazole, the raw materials are easy to obtain, the cost is low, and the yield can reach 60%.

Preparation technology for 3-aryl-4-nitro isoxazole compound

The invention discloses a preparation technology for a 3-aryl-4-nitro isoxazole compound. The preparation technology comprises the following steps: synthesizing a compound shown as formula II through the nucleophilic addition of hydroxylamine hydrochloride and the compound shown as formula I used as the raw material; acquiring the compound shown as formula III through the substitution reaction of the compound shown as formula II and N-chlorosuccinimide; preparing 1-dimethyl amino-2-nitro ethylene through the reaction of N,N-dimethylformamide dimethyl acetal and nitromethane used as the raw material; and acquiring a target product 3-aryl-4-nitro isoxazole compound through the cyclization reaction of the compound shown as formula III and 1-dimethyl amino-2-nitro ethylene. The raw materials in the synthesis route are low in cost and easily acquired, the operation condition is mild and is easily controlled, the product is easily purified and the preparation technology is a new method for synthesizing the 3-aryl-4-nitro isoxazole compound.

Reactions of silyl nitronates with dimethylformamide dimethyl acetal as a new general procedure for the synthesis of 2-nitroenamines

Silyl nitronates obtained in situ from the corresponding aliphatic nitro compounds react with dimethylformamide dimethyl acetal giving 2-nitroenamines in moderate to good yields. The reaction pathway is discussed.