73748-78-4

Usage

Type of compound

Nonsteroidal anti-inflammatory drug (NSAID)

Derivative of

Salicylic acid

Properties

Analgesic, anti-inflammatory, and antipyretic

Uses

Relief of pain and reduction of inflammation associated with conditions such as arthritis, headache, and menstrual cramps

Mode of action

Inhibition of prostaglandins production

Available forms

Oral tablets and topical cream

Safety guidance

Use under the guidance of a healthcare professional to ensure safe and effective use.

Upstream product

• 6282-12-8 2,4-diacetylaminotoluene 
• 603-12-3 2,6-dinitrobenzoic acid 
• 108-24-7 acetic anhydride 
• 95-80-7 4-methylbenzene-1,3-diamine 

Downstream Products

• 611-03-0 4-amino-2-aminobenzoic acid 
• 1606159-00-5 C₈H₇N₃OS 

Relevant academic research and scientific papers

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.

Preparation of Some Acetylated, Reduced and Oxidized Derivatives of 2,4-Diaminotoluene and 2,6-Dinitrotoluene

4-Acetylamino-2-hydroxylaminotoluene (4AA2HAT) and 2-hydroxylamino-6-nitrotoluene (2HA6NT) were prepared from 4-acetylamino-2-nitrotoluene (4AA2NT) and 2,6-dinitrotoluene (2,6-DNT), respectively, by reduction with zinc dust and NH4Cl. 2,6-Dinitrobenzylalcohol (2,6-DNB) and 2,6-dinitrobenzoic acid (2,6-DNBA) were prepared from 2,6-dinitrobenzaldehyde (2,6-DNBAl) by reduction with NaBH4 and by oxidation with KMnO4, respectively. 2-Acetylamino-4-aminobenzoic acid (2AA4ABA) was prepared from 4-nitroanthranilic acid (4NAA) by acetylation followed by reduction with NaBH4 and Pd-C. 2,4-Diacetylaminobenzoic acid (2,4-DAABA) was prepared from 4NAA by reduction with NaBH4 and Pd-C followed by acetylation. 4-Acetylamino-2-aminobenzoic acid (4AA2ABA) was prepared from 4NAA by reduction and acetylation followed by chelation with Cu(AcO)2.Keywords- 4-acetylamino-2-hydroxylaminotoluene; 2-hydroxylamino-6-nitrotoluene; 2,6-dinitrobenzylalcohol; 2,6-dinitrobenzoic acid; 2-acetylamino-4-aminobenzoic acid; 4-acetylamino-2-aminobenzoic acid; 2,4-diacetylaminobenzoic acid; carcinogenicity; mutagenicity; preparation