73748-78-4

Basic information

• Product Name: 2,4-bis(acetylamino)benzoic acid
• Synonyms: benzoic acid, 2,4-bis(acetylamino)-
• CAS NO: 73748-78-4
• Molecular Formula: C₁₁H₁₂N₂O₄
• Molecular Weight: 236.224
• Mol File: 73748-78-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 560.4°C at 760 mmHg
• Flash Point: 292.7°C
• Density: 1.404g/cm³
• Vapor Pressure: 2.14E-13mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 2,4-bis(acetylamino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-bis(acetylamino)benzoic acid(73748-78-4)
• EPA Substance Registry System: 2,4-bis(acetylamino)benzoic acid(73748-78-4)

Safety Data

• Hazardous Substances Data: 73748-78-4(Hazardous Substances Data)

Usage

Type of compound

Nonsteroidal anti-inflammatory drug (NSAID)

Derivative of

Salicylic acid

Properties

Analgesic, anti-inflammatory, and antipyretic

Uses

Relief of pain and reduction of inflammation associated with conditions such as arthritis, headache, and menstrual cramps

Mode of action

Inhibition of prostaglandins production

Available forms

Oral tablets and topical cream

Safety guidance

Use under the guidance of a healthcare professional to ensure safe and effective use.

Upstream product

• 95-80-7 4-methylbenzene-1,3-diamine 
• 603-12-3 2,6-dinitrobenzoic acid 
• 108-24-7 acetic anhydride 
• 6282-12-8 2,4-diacetylaminotoluene 

Downstream Products

• 1606159-00-5 C₈H₇N₃OS 
• 611-03-0 4-amino-2-aminobenzoic acid 

Relevant articles and documents

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.