7403-41-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-N-ethylbenzamide is utilized as a building block for the synthesis of various drugs and pharmaceuticals, contributing to the development of new therapeutic agents.
Used in Pain Management:
As an analgesic, 4-Methoxy-N-ethylbenzamide is employed for the management of pain, providing relief to patients suffering from various types of discomfort.
Used in Fever Reduction:
4-Methoxy-N-ethylbenzamide serves as an antipyretic drug, helping to reduce fever and associated symptoms in patients.
Used in Anti-Inflammatory Treatments:
Leveraging its anti-inflammatory properties, 4-Methoxy-N-ethylbenzamide is used in treatments aimed at reducing inflammation and associated discomfort.
Used in Anticancer Research:
4-Methoxy-N-ethylbenzamide is studied for its potential as an anticancer agent, with ongoing research exploring its effectiveness against various types of cancer.
Used in Neurological and Psychiatric Disorder Treatments:
4-Methoxy-N-ethylbenzamide is also being investigated for its potential applications in the treatment of neurological and psychiatric disorders, offering hope for new therapeutic approaches in these areas.

InChI:InChI=1/C10H13NO2/c1-3-11-10(12)8-4-6-9(13-2)7-5-8/h4-7H,3H2,1-2H3,(H,11,12)

Upstream product

• 701-53-1 p-methoxybenzoyl fluoride 
• 75-04-7 ethylamine 
• 874-90-8 4-methoxybenzonitrile 
• 105-58-8 Diethyl carbonate 
• 15226-74-1 dicobalt octacarbonyl 
• 104-93-8 p-methylanizole 
• 100-09-4 4-methoxybenzoic acid 
• 22993-76-6 N-ethyl-4-methoxybenzenemethanamine 
• 5796-97-4 bis(triethylsilyl) peroxide 
• 3424-93-9 4-methoxyphenylacetamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 1290636-90-6 C₁₄H₁₀ClNO₅ 
• 100-07-2 4-methoxy-benzoyl chloride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1379773-07-5 N-ethyl-2-iodo-4-methoxybenzamide 
• 73894-89-0 acetyl-p-methoxybenzoylimide 
• 22993-76-6 N-ethyl-4-methoxybenzenemethanamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 90389-68-7 N-(4-methoxybenzyl)ethylamine hydrochloride 
• 95845-31-1 ethyl-(4-methoxy-benzyl)-dimethyl-ammonium; iodide 

Relevant academic research and scientific papers

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Method for synthesizing amide by using methyl arene and amine in water phase

The invention provides a high-efficient method of synthesizing amide with methyl aromatics and amine. In the method, with the methyl aromatics and the amine as the raw materials in the water phase and TBHP and TBAI respectively as an oxidizing agent and a catalyst, a sp3 C-H bond and a sp3 N-H bond are broken and a C-N bond is formed. Compared with a conventional method of synthesizing the amide from oxidized amide, in which an activated acyl group or amine is required, the method is carried out with water as the solvent so that the method is not only economical but also environmental-protective. The method has a very good application prospect in the field of synthesizing polypeptide, protein and drugs in future.

Generation of alkyl radicals from alkylsilyl peroxides and their applications to C-N or C-O bond formations

This article describes a novel method for the generation of alkyl radicals from alkylsilyl peroxides and their applications to the Cu-catalyzed mono-N-alkylation of amides or arylamines, and to the O-alkylation of carboxylic acids. The use of alkylsilyl peroxides as alkyl radical sources includes the following synthetic advantages: i) various alkylsilyl peroxides can be readily synthesized from the corresponding alcohols and be stored at bench, and ii) a variety of alkyl radicals can be generated efficiently under mild conditions.

Visible-Light-Driven Oxidation of N -Alkylamides to Imides Using Oxone/H 2 O and Catalytic KBr

Imides are prepared conveniently by visible-light-driven oxidations of various N -alkylamides under mild conditions. The majority of the reactions proceed efficiently by using Oxone as the oxidant in the presence of a catalytic amount of KBr in H 2 O/CH 2 Cl 2 under irradiation by an 8 W white LED at room temperature. Experimental studies suggest that an imine, obtained from the substrate amide via a radical process, is the key intermediate.

Metal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH2-Oxygenation of Free Amines

Direct oxidation of α-CH2 group of free amines is hard to achieve due to the higher reactivity of amine moiety. Therefore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence or absence of hazardous oxidants under sensitive reaction conditions. A novel method for direct C-H oxygenation of aliphatic amines through a metal-free activation of molecular oxygen has been developed. Both activated and unactivated free amines were oxygenated efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationally simple conditions without the aid of metallic reagents and toxic oxidants. The method has been applied to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide.

Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-: N -alkylation of primary amides

The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.

Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines

The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the alkylsilyl peroxides, as well as to the primary amides and arylamines. Mechanistic studies suggest that the present reaction should proceed through a free-radical process that includes alkyl radicals generated from the alkylsilyl peroxides.

Aminofluorene-Mediated Biomimetic Domino Amination-Oxygenation of Aldehydes to Amides

A conceptually novel biomimetic strategy based on a domino amination-oxygenation reaction was developed for direct amidation of aldehydes under metal-free conditions employing molecular oxygen as the oxidant. 9-Aminofluorene derivatives acted as pyridoxamine-5′-phosphate equivalents for efficient, chemoselective, and operationally simple amine-transfer oxygenation reaction. Unprecedented RNH transfer involving secondary amine to produce secondary amides was achieved. In the presence of 18O2, 18O-amide was formed with excellent (95%) isotopic purity.

Direct oxidative amidation between methylarenes and amines in water

An environmentally friendly direct oxidative amidation between methylarenes and free amines was developed. The aromatic amide could be prepared efficiently from raw chemicals by employing TBHP as a "green" oxidant with co-catalysis of TBAI and FeCl3 in water.

Metal-Free Synthesis of Dibenzoxazepinones via a One-Pot SNAr and Smiles Rearrangement Process: Orthogonality with Copper-Catalyzed Cyclizations

Reported is the transition-metal-free synthesis of substituted dibenzoxazepinones using a convergent domino SNAr-Smiles rearrangement-SNAr process. Substrate-scope investigations demonstrated the critical importance of ring electroni