742104-84-3Relevant academic research and scientific papers
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones
Kang, Ji-Hye,Siddiqui, Maqbool A.,Sigano, Dina M.,Krajewski, Krzysztof,Lewin, Nancy E.,Pu, Yongmei,Blumberg, Peter M.,Lee, Jeewoo,Marquez, Victor E.
, p. 2413 - 2416 (2004)
(Equation Presented) Commercially available 2-methylenepropane-1,3-diol was converted to chiral epoxide (R)-2 via Sharpless asymmetric epoxidation in >96% ee. Regiospecific epoxide ring opening and reduction of the intermediate alkyne set the stage for a
PROTEIN KINASE C AGONISTS
-
Paragraph 0319; 0321, (2020/09/12)
The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by protein kinase C (PKC) agonists, such as HIV.
PROTEIN KINASE C AGONISTS
-
Paragraph 0287; 0289, (2020/09/12)
The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions dis
