7438-46-2Relevant academic research and scientific papers
Sensitive spectrophotometric method for determination of some phenothiazine drugs
Upadhyay, Kanchan,Asthana, Anupama,Tamrakar, Raunak Kumar
, p. 7481 - 7495 (2015/02/19)
A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed. The proposed method is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05-4.0, 0.02-2.0, 0.05-5.0, 0.1-8.0, and 0.05-2.0 μg mL-1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.
Molecular recognition studies on supramolecular systems. 32. Molecular recognition of dyes by organoselenium-bridged bis(β-cyclodextrin)s
Liu,Li,You,Wada,Inoue
, p. 225 - 232 (2007/10/03)
A series of novel bis(β-cyclodextrin)s tethered with organoselenium linkers, i.e., 6,6′-(o-phenylenediseleno)-bridged bis(β-cyclodextrin) (2), 6,6′-[2,2′-diselenobis(benzoyloxy)]-bridged bis(β-cyclodextrin) (3), and 6,6′-[2,2′-diselenobis[2-(benzoylamino)ethylamino]]-bridged bis(β-cyclodextrin) (4), were synthesized from β-cyclodextrin (1). The inclusion complexation behavior of 1-4 with some dyes, such as 8-anilinonaphthalenesulfonate (ANS), Brilliant Green, Crystal Violet, Tropaeolin OO, Auramine O, and Methyl Orange, was investigated in aqueous phosphate buffer solution (pH 7.20) at 25 °C by UV-vis, fluorescence, and circular dichroism spectrometry, as well as fluorescence lifetime measurements. The complex stability constants (KS) and Gibbs free energy changes (δG°) for the stoichiometric 1:1 inclusion complexation of 1-4 with the dyes were obtained by the spectrophotometric or spectropolarimetric titrations. The bis(β-cyclodextrin)s 2-4 showed much higher affinities toward these guest dyes than native β-cyclodextrin I with fairly good molecular selectivities. The cooperative binding abilities of these bis(β-cyclodextrin)s are discussed from the viewpoints of size/shape-fit interaction, induced-fit concept, and multiple recognition mechanism.
MECHANISM OF THE HYDRIDE TRANSFER REACTION OF LEUCO CRYSTAL VIOLET WITH CYANOMETHYLENE ACCEPTORS
Nishimura, Norio,Zaman, Khan M.,Yamamoto, Shunzo
, p. 218 - 220 (2007/10/02)
In the hydride transfer reaction of Leuco Crystal Violet to form the Crystal Violet cation, the role of cyanomethylene acceptors was found to be essentially different from that of p-benzoquinones, both previously believed to act as ?-acceptors in the same manner.
Photochemical Reaction of Diaryliodonium Salts with Dimethylaniline
Bi, Yubai,Neckers, Douglas C.
, p. 1139 - 1142 (2007/10/02)
A solution of 4,4'-dimethyldiphenyl iodonium tettrafluoroborate and N,N-dimethylaniline in acetonitrile is irradiated by UV light to give iodotoluene, toluene, 4,4'-methylenebis(N,N-dimethylaniline), crystal violet, methyl violet. KEY WORDS: 4,4'-dimethyldiuphenyl iodonium salt; N,N-dimethylaniline; 4,4'-methylenebis(N,N-dimethylaniline); crystal violet; methyl violet.
KINETIC ISOTOPE AND PRESSURE EFFECTS IN THE REACTION OF LEUCOCRYSTAL VIOLET WITH TETRACYANOETHYLENE AND CHLORANIL.
Nishimura,Motoyama
, p. 1 - 7 (2007/10/02)
The rates of reaction of Leucocrystal Violet (LCV) with chloranil (CA) and tetracyanoethylene (TCNE) were measured, and the kinetic isotope and pressure effects were examined. In the LCV-CA system, a very large isotope effect was observed, while in the LCV-TCNE system, it was not so large (k//H/k//D equals 5-6) suggesting the tunnel effect is not substantial. For both systems, the formation of a CT complex in equilibrium with the reactants was observed at low temperatures ( less than minus 50 degree C). From the rate law, the isotope effect, the electronic and ESR spectra observed during the reaction, and their time dependence, possible reaction processes are proposed.
Electron Transfer Sensitization. III. A Kinetic Study of Oxidative Dye Formation from Leuco Crystal Violet
Kitamura, Noboru,Tazuke, Shigeo
, p. 2598 - 2604 (2007/10/02)
The action of electron transfer sensitization was quantitatively discussed by measuring photooxidative dye formation of leuco Crystal Violet (LCV) in the perylene(Pe)-1,4-dicyanobenzene(DCB)-LCV combination in polar media.Under the conditions of exclusive
